Carolina Panthers vs. Arizona Cardinals, Picks and Prediction, Sunday, September 14, 2025
Use Code WWWC Carolina (0-1) will be trying to pick up their first win of the season when they visit State Farm Stadium on Sunday afternoon to face Arizona (1-0) at 4:05 PM. ET. Read on to find out which team picks up the win in this Panthers vs. Cardinals prediction. If you need quality winners, this is the ultimate site for NFL Picks.
The Panthers are coming off a 26-10 loss to Jacksonville as 4.5-point underdogs. The Cardinals are coming off a 20-13 win over New Orleans as 5.5-point favorites.
Carolina is 7-3 in its last 10 games against Arizona. The Panthers won last season’s meeting, 36-30 in overtime.
Carolina Trying To Bounce Back From Loss
The Panthers didn't put up much of a fight in their first game, and they were dominated by Jacksonville in the loss by 16 points. They will try to put the loss behind them and pick up their first win of the season when they play on Sunday.
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Carolina scored 10 points in their first game. They threw for 142 yards and rushed for 113 yards in the loss.
Bryce Young completed 51 percent of his passes for 154 yards, one touchdown, and two interceptions. He also had five carries for 40 yards. Chuba Hubbard led the team with 16 carries for 57 yards, while Tetairoa McMillan had five catches for 68 yards. Last season, Young threw for two touchdown passes and ran for 68 yards in a 36-30 win at home against the Cardinals.
Carolina gave up 26 points in their first game. They allowed 178 passing yards and 200 rushing yards in the loss. They could use somebody to step on the defensive line with Tershawn Wharton (hamstring) out 2-4 weeks. Wharton had four tackles in the opener and 6.5 sacks as a defensive tackle last season for the Chiefs.
Arizona Going For Second Consecutive Win
The Cardinals got their season off to a good start with a win over the Saints in their first game. They will try to keep the momentum going and pick up their second straight win when they play on Sunday.
Arizona scored 20 points in its first game. They threw for 130 yards and rushed for 146 yards in the win.
Kyler Murray completed 72 percent of his passes for 163 yards and two touchdowns. He also had seven carries for 38 yards. Last season against the Panthers, Murray rushed for 63 yards. Trey Benson had eight carries for 69 yards, while Marvin Harrison Jr. had five catches for 71 yards and one touchdown. Star tight end Trey McBride also added six catches for 61 yards with nine targets.
Arizona gave up just 13 points in their first game. They allowed 208 passing yards and 107 rushing yards in the win.
Carolina Panthers vs. Arizona Cardinals Pick
Point Spread Pick for Carolina Panthers vs. Arizona Cardinals
- Arizona Cardinals -7 (4 Units)
The Cardinals didn’t put up big numbers in their first game, but they played well offensively with a balanced attack. The Panthers did a good job defending the pass in their first game, but they were gashed on the ground, with the Jaguars racking up 200 yards, so expect the Cardinals to follow a similar game plan and keep the ball on the ground until the Panthers prove they can stop them from running against them, which I don't expect to happen.
Carolina’s offense didn’t do much in their first game. They were unable to get anything going through the air, but they averaged 4.5 yards per carry. Unfortunately for them, the Cardinals did a good job against the run in their first game and bottled up Alvin Kamara, who finished with less than 50 rushing yards. So expect the Cardinals to stack the box and keep pressure on Young all day long, forcing him into costly mistakes, so expect them to have a hard time keeping up with the Cardinals. Go with Arizona to cover the spread.
Over/Under Pick for Carolina Panthers vs. Arizona Cardinals
- Under 44 (4 Units)
The Panthers and Cardinals both played under the total in their first game. Carolina scored 10 points in their first game and did most of their damage on the ground, where they picked up more than 110 yards. They are facing an Arizona team that defended the run well and gave up 13 points in their first game, so expect more of the same here. The Cardinals scored 20 points in their first game. They moved the ball well on the ground, picking up more than 140 yards. Even though they are facing a team that gave up 200 yards on the ground and 26 points in their first game, the Cardinals won’t score enough points to push the score over the total.
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