Cincinnati Reds vs. Athletics Picks and Prediction for Friday, September 12, 2025

By: Victor King Published 09/12/2025, 10:43 AM ET
Reds vs. Athletics prediction
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Cincinnati Reds (74-72) vs. Athletics (67-80) 

The MLB betting action continues Friday, September 12, 2025, with the full 15-game card, including the interleague showdown at Sutter Health Park in Sacramento, CA, so we’ve got the Reds vs. Athletics prediction and the latest odds update.

The Athletics host the Reds for the opener of their three-game regular-season series. Last season, the Athletics took two out of three from the Reds in Cincinnati, and the A’s are slight -120 moneyline favorites to beat the Reds on Friday night.

Read more about this Reds vs. A’s prediction, and check out all our MLB picks for Friday’s slate. The first pitch at Sutter Health Park is set at 10:05 PM ET.

The Reds are chasing the wild card                           

The Cincinnati Reds have won their last two series, taking two out of three games from the New York Mets and San Diego Padres. The Reds returned to the playoff race, trailing the final wild-card spot in the National League by two games on Thursday morning.

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Cincinnati is coming off Wednesday’s 2-1 road victory over the Padres. Andrew Abbott threw eight innings of a one-run, five-hit ball, and the Reds scored two runs in the top of the eighth to see off the Padres’ challenge. Cincinnati is slashing .242/.303/.399 with 10 home runs in September (306 at-bats).

Brady Singer will be on the bump Friday, and the 29-year-old right-hander is 13-9 with a 3.98 ERA and 1.26 WHIP in 28 starts (149.1 innings pitched) this season. He’s done a great job over his last five starts, posting a 4-0 record with a shiny 1.80 ERA and 2.11 FIP.

Singer is 1-3 with a 4.85 ERA in five career starts against the Athletics. He met them once in 2024, throwing six innings of a one-run, six-hit ball in the Royals’ 8-4 victory over the A’s. The current Athletics are 7-for-23 with three doubles and a home run against Singer, who spent the last five years in the American League.

The A’s have nothing to play for                                          

The Athletics are coming off Wednesday’s 5-4 home victory over the Boston Red Sox. The A’s stopped a three-game slide and avoided a sweep in a three-game series against the Sawx. They were 11.5 games behind the bottom wild card in the American League on Thursday morning.

The A’s have struggled lately, going 4-8 in their previous 12 games overall. They are hitting a sturdy .283/.345/.477 with 14 home runs in September (325 at-bats), but their starting rotation has struggled so far this month, posting a 5.00 ERA and a .269 batting average against. The A’s bullpen holds a 3.55 ERA and 1.12 WHIP in September.

J.T. Ginn is projected to get the starting call Friday, and the 26-year-old righty carries a 3-6 record with a troublesome 4.95 ERA and 1.34 WHIP in 13 starts and seven relief appearances (76.1 IP) in 2025. Over his last five outings, Ginn has gone 1-2 with a 6.26 ERA and 3.88 FIP.

Ginn will meet the Reds for the second time in his young career. Last year, he gave up four earned runs on four hits and a walk across five innings of work in a no-decision at Great American Ball Park in Cincinnati. The current Reds are 2-for-13 with a couple of home runs against Ginn.

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Reds vs. Athletics Pick 

Moneyline Pick for Reds vs. Athletics   

  • Cincinnati Reds (5 units) 

I don’t trust J.T. Ginn at all, so give me the Reds at plus money. Ginn pitched well last Saturday, allowing one earned run on five hits through five innings in a 17-4 dismantling of the Angels. However, Ginn was terrible in August, going 0-4 with a 7.24 ERA in six starts and 27.1 innings of work. Moreover, he’s allowed a whopping 18 runs (17 earned) across his previous four showings at home (17.2 IP).

As I mentioned, Brady Singer has been nothing short of spectacular lately. Keeping the Athletics quiet won’t be an easy task by any means, but I expect Singer to give his team a chance. Of course, the Reds will need a solid display from their bullpen, which could be a problem. However, should Singer continue to impress, the Reds will use their best relievers in this game.

Over/Under Pick for Reds vs. Athletics   

  • Under 10.0 (5 runs)  

I’m backing Brady Singer to pitch well, even though the Athletics boast a .943 OPS and 160 wRC+ against the righties in September. Also, I expect the Reds to get to J.T. Ginn despite the fact that they own a .680 OPS and 83 wRC+ against the righties this month.

Hereof, I will take the under on the total, and Singer’s performance will be a key factor. In 12 of Singer’s last 14 starts, we saw fewer than 10 runs on the scoreboard. Moreover, seven of the Reds’ last nine games overall and six of the Athletics’ previous eight have produced runs in single digits.

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