Cincinnati Reds vs. San Diego Padres, Picks and Prediction, Wednesday, September 10, 2025
Cincinnati (72-72) will be trying to keep its playoff hopes alive when they visit Petco Park on Wednesday night to face San Diego (79-65) in the final game of their three-game series at 8:40 PM. ET. Read on to find out which team picks up the win in this Reds vs. Padres prediction. Need a hot take on the MLB Season? Check out our Free MLB Picks and cash in.
Andrew Abbott, 8-6, 2.88 ERA, will get the start for the Reds. The Padres will counter with Nick Pivetta, 13-5, 2.85 ERA.
San Diego is 6-4 in its last 10 games against Cincinnati.
**This preview was written before Tuesday’s game was played.**
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Cincinnati Trying To End Road Woes
The Reds followed up their series loss to Toronto with a series win over the Mets. They struggled in recent road games, losing seven of their last eight road games, and will try to turn things around with a win on Wednesday.
Cincinnati averages 4.51 runs per game, which is 13th in the league. Their .247 batting average is 16th in the league. Their .317 on base percentage is also 16th, while their .392 slugging percentage is 22nd.
Gavin Lux leads Cincinnati with a .268 batting average, while Elly De La Cruz leads the team with 19 home runs and 81 RBI.
Cincinnati is giving up 4.31 runs per game, which is 16th in the league. Opponents have a .237 batting average against the Reds, which is seventh in the league. Their 3.93 ERA is 16th, while their 1.25 WHIP is 10th.
In his last start, Abbott gave up nine hits and five runs in 4.2 innings, leading to a 5-4 loss to the Mets. He is 1-0 with a 0.92 ERA in three games against San Diego.
San Diego Going For Second Consecutive Series Win
The Padres followed up their five-game losing streak with three straight wins. They are second in the NL West standings, one game behind the Dodgers, and will try to move into a tie for first with a win on Wednesday.
San Diego averages 4.26 runs per game, which is 22nd in the league. Their .252 batting average is seventh in the league. Their .322 on base percentage is ninth, while their .387 slugging percentage is 27th.
Luis Arraez leads San Diego with a .283 batting average, while Manny Machado leads the team with 23 home runs and 84 RBI.
San Diego is giving up 3.88 runs per game, which is second in the league. Opponents have a .226 batting average against the Padres, which leads the league. Their 3.66 ERA is third, while their 1.21 WHIP is fourth.
In his last start, Pivetta gave up seven hits and two runs in six innings, leading to a 3-0 loss to Colorado. He is 1-1 with a 3.41 ERA in 10 games against Cincinnati.
Cincinnati Reds vs. San Diego Padres Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vincilleti | +1,778.00 |
| 2 |  Ross Benjamin | +1,716.00 |
| 3 |  David Hess | +1,326.00 |
| 4 |  Earle Sports Bets | +1,323.00 |
| 5 |  Dan Kaiser | +1,071.00 |
Money Line Pick for Cincinnati Reds vs. San Diego Padres
- San Diego Padres ML (4 Units)
The Padres have won three of their last four games, while the Reds have lost four of their last six games. San Diego has the edge here because they’ve had a lot of success batting against left-handers, and they’re going up against Abbott, who struggled on the mound in recent starts, giving up 14 runs in his last three starts. He gave up 13 runs in his last three road starts and will have a hard time slowing down the Padres.
Cincinnati won’t be as successful offensively because they didn’t hit the ball well in recent road games, and they’re going up against Pivetta, who has looked good on the mound, giving up eight runs in his last four starts. He gave up three runs in his last two home starts and will keep Cincinnati’s offense in check. Take San Diego on the money line.
Over/Under Pick for Cincinnati Reds vs. San Diego Padres
- Under (4 Units)
The Reds played under the total in three of their last four games, while the Padres played under the total in their last two games. Cincinnati averages 4.51 runs per game and averaged four runs per game in their last three games. They’re batting .253 against right-handers, and they’re facing a starter who gave up three runs in his last two home starts. The Padres average 4.26 runs per game and 4.35 runs per game at home. They’re batting .244 against left-handers, and they’re facing a starter who gave up two runs in three starts against them. Don’t expect these teams to score enough runs to push the score over the total. The Padres and Reds played under the total in their last two meetings.
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