Buffalo vs. DePaul, Picks and Prediction, Tuesday, November 11, 2025

By: Bosun Akinpelu Published 11/11/2025, 03:38 AM ET
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Buffalo (2-0, 0-0 MAC) will be going for their third consecutive win when they visit Wintrust Arena on Tuesday night to face DePaul (2-0, 0-0 Big East) at 8 PM. ET. Read on to find out which team picks up the win in this Bulls vs. Blue Demons prediction. Nobody does it better when it comes to free NCAAB picks!

The Bulls are coming off an 83-76 win over Green Bay as four-point favorites. The Blue Demons are coming off a 72-64 win over Stonehill as 22.5-point favorites.

Buffalo won the lone meeting between the two teams in 2019, 74-69.

Buffalo Going For First Road Win

The Bulls are off to a good start this season after picking up wins in their first two games. They are hitting the road for the first time and will try to pick up their first road win of the season when they play on Tuesday.

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Buffalo averages 84 points per game through two games. They’ve made 49 percent of their field goals and 39.1 percent of their three-pointers.

Ryan Sabol leads the Bulls with 20.5 points and 2.5 assists per game. Daniel Freitag averages 13.5 points and 2.5 rebounds per game, while Derrick Talton Jr. averages 12.5 points and four assists per game.

Buffalo is giving up 77.5 points per game through two games. Opponents have made 53 percent of their field goals and 38 percent of their three-pointers against them.

DePaul Going For Third Consecutive Win

The Blue Demons kicked off their season with wins over Chicago State and Stonehill. They will try to keep the momentum going and pick up their third straight win when they play on Tuesday.

DePaul averages 82 points per game through two games. They’ve made 44 percent of their field goals and 27 percent of their three-pointers.

CJ Gunn averages 20 points and 4.5 rebounds per game. NJ Benson averages 16 points and 10 rebounds per game, while Layden Blocker averages 10 points and four assists per game.

DePaul is giving up 63 points per game through two games. Opponents have made 39 percent of their field goals and 33 percent of their three-pointers against them.

Buffalo vs. DePaul Picks

Point Spread Pick for Buffalo vs. DePaul

  • Buffalo Bulls to cover. (4 Units)

Both teams won their first two games. The difference between them is the quality of their opponents, with Buffalo having a slight edge. The Bulls have played well offensively, making close to 50 percent of their shots. They’ve also done a better job at the charity stripe. They rebound the ball well and grab more than 10 offensive rebounds per game, which will give them more scoring chances. They also do a good job of protecting the ball and won’t give up many easy-scoring chances. Even though the Blue Demons have played well defensively, they haven’t played a team that’s as good offensively, and will have a hard time slowing down the Bulls. Go with Buffalo to cover the spread.

Over/Under Pick for Buffalo vs. DePaul

  • Under (4 Units)

The Blue Demons played under the total in two of their last three games, while the Bulls played under the total in two of their last four games. DePaul is averaging 82 points per game through two games. They play at the 93rd-fastest pace in the country, averaging 77.1 possessions per game, and they’re facing a team that is giving up 77.5 points per game. The Bulls average 84 points per game. They play at the 342nd-fastest pace in the country, averaging 65.5 possessions per game, and they’re facing a team that is giving up 63 points per game. Don’t expect these teams to score enough points to push the score over the total.

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