Clemson Tigers vs. Alabama Crimson Tide Picks and Prediction for Wednesday, December 3, 2025
It’s a contest on the hardwood between power conference foes as the Clemson Tigers travel to the Yellowhammer State to battle the #12 Alabama Crimson Tide Wednesday night as part of the ACC/SEC Challenge, and we have you covered with our Clemson vs. Alabama prediction. Clemson dropped Alabama A&M 92-56 at home in their previous contest Friday night, covering the line as a 28.5-point favorite. Alabama bombed Maryland 105-72 on the road Wednesday night in a consolation matchup of the Players Era Championship Tournament, covering the line as a 14.5-point favorite. In the all-time series between the programs, the Crimson Tide owns an 8-5 advantage, including an 89-82 victory in the most recent matchup which came in the Elite Eight of the 2024 NCAA Tournament on March 30, 2024. Read more about this Clemson vs. Alabama prediction! Struggling with handicapping? Try our NCAAB Predictions!
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Clemson Looking for Fifth Straight Victory
Clemson earned their fourth straight victory in their previous contest as they took down Alabama A&M at home Friday night. The Tigers improved to 7-1 on the season and look to earn a win over a ranked opponent on the road here. Against Alabama A&M, Clemson led wire-to-wire as they scored the game’s first seven points en route to a 52-22 halftime advantage. The Tigers led by as many as 38 in the game en route to the blowout win. Clemson shot 54.5% from the floor, including eight of 23 from three-point range, and controlled the glass by a 44-23 margin. Jestin Porter led the Tigers with 14 points in the win.
On the year, Clemson is 73rd in the nation in scoring offense, averaging 85.2 points per game. Clemson is above average in the rebounding department, collecting 42.3 boards a night (35th), while they are 95th in assists, dishing out 16.4 a game. The Tigers are above average defensively as they are 25th in scoring defense by allowing 63.8 points per game. Carter Welling leads the Tigers and is one of three players averaging in double figures as he puts up 11.6 points plus 6.5 rebounds a night this season. RJ Godfrey (11.3 points, 6.8 rebounds) and Jestin Porter (11 points) are good secondary options. Dillon Hunter, Ace Buckner, Nick Davidson, Jake Wahlin, Zac Foster, Butta Johnson, Dallas Thomas and Chase Thompson are all needed to contribute for coach Brad Brownell. Clemson shoots 47.1% from the field this season as a team, which is 62nd in the country. The Tigers connect on 9.3 three-point field goals per game (90th) while shooting 33.8% from beyond the arc (181st) on the year. Clemson has been above average at the line this season, connecting on 74.4% of their attempts, which is 100th in the country.
Key Injury Report for Clemson:
- No Key Injuries
Crimson Tide Seeking Third Straight Win
Alabama bounced back from a loss to #12 Gonzaga by dropping UNLV and Maryland in one-sided fashion to leave Las Vegas on a positive note. The Crimson Tide improved to 5-2 on the season and their two losses are to ranked foes Purdue and Gonzaga as they take the floor here. Against Maryland, Alabama bolted to a 10-2 lead just over two minutes into the game and didn’t look back. The Crimson Tide rolled to a 49-29 advantage at the half and led by as many as 39 en route to the win. Alabama shot 57.6% from the field, including 14 of 31 from three-point range, and controlled the glass by a 49-30 margin. Labaron Philon Jr. led seven Crimson Tide players in double figures with 20 points and six assists in the win.
For the year, Alabama is averaging 95.6 points per game this season, putting them 7th in the nation in scoring offense. The Crimson Tide collects an average of 41.1 rebounds per game (52nd in the country) while they dish out an average of 18.5 assists a night. Alabama is surrendering an average of 82 points a night this season, putting them 325th in the country in scoring defense. Labaron Philon Jr. is one of four players averaging in double figures for the Crimson Tide as he leads the way with 20.6 points, 2.9 rebounds and 5.7 assists per game this season. Aden Holloway (18.2 points, 4.3 assists), Latrell Wrightsell (9.3 points), Taylor Bol Bowen (10.9 points, 4.7 rebounds) and Houston Mallette (10 points) are secondary scoring options. Aiden Sherrill, Amari Allen, London Jemison, Keitenn Bristow, Davion Hannah, Noah Williamson and Collins Onyejiaka are among those who have to step up offensively for coach Nate Oats. The Crimson Tide is decent when it comes to shooting the ball as they are hitting 49.7% from the field as a team on the year, putting them 46th in Division I. Alabama knocks down an average of 12.1 three-pointers a night (5th) while sinking 36.3% from beyond the arc, which is 90th in the nation. The Crimson Tide is average at the charity stripe as they convert 74.7% of their chances at the line, putting them 87th in the country.
Key Injury Report for Alabama:
- Forward Latrell Wrightsell (undisclosed) is questionable.
- Center Keitenn Bristow (lower leg) is questionable.
Clemson vs. Alabama Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vinciletti | +1,570.00 |
| 2 |  Dan Kaiser | +1,223.00 |
| 3 |  Ross Benjamin | +1,000.00 |
| 4 |  Earle Sports Bets | +916.00 |
| 5 |  David Hess | +706.00 |
Clemson vs. Alabama Spread Pick
- Alabama -9 (4 units)
Clemson comes in with four straight wins, but their defense will be severely tested taking on the Crimson Tide’s offensive attack. The Tigers are above average offensively but they don’t have the scoring depth that Alabama brings to the table. Alabama has seven players scoring more than nine points a night, so they’re able to rotate pieces in and out without losing much in the way of firepower. Clemson will have to prevent Alabama from controlling the tempo and enforcing their will. The Tigers downed West Virginia and Georgia on a neutral floor, though they dropped their lone true road game at Georgetown. Alabama is tougher than the Hoyas and that helps carry them to a victory here.
Clemson vs. Alabama Over/Under Pick
- Over 163.5 (4 units)
Clemson has seen the over post a 5-3 mark in their eight games this season. The Tigers are 27th in offensive efficiency, 85th in effective field goal percentage (54.6%), 57th in offensive rebounding percentage (36.1%) and 12th in turnover percentage (13.1%) this season. Clemson is 301st in adjusted tempo as they average 66.8 possessions per game according to KenPom. Alabama has seen the over post a 4-3 mark in their seven games on the year. The Crimson Tide is 3rd in offensive efficiency, 21st in effective field goal percentage (58.7%), fifth in threes per game and 27th in turnover percentage (14%) this season. Alabama is eighth in tempo according to KenPom with 74.5 possessions a night. Look for the Crimson Tide to push the pace and that helps this one over the total.
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