Creighton Bluejays at Xavier Musketeers, Picks and Prediction for Wednesday, December 17, 2025

By: David Delano Published 12/17/2025, 10:38 AM ET
Use Code WWWC

Creighton (5โ€“5) travels to Cincinnati to face a surging Xavier (8โ€“3) squad at the Cintas Center, in what will be the Big East opener for both teams. Last season, these teams split their head-to-head meetings, with the home team winning and covering each time.

Creighton enters this game rated No. 72 overall according to KenPom, and Cincinnati is No. 84.

For David Delanoโ€™s full Creighton vs. Xavier prediction, keep reading, and check out all the free college basketball picks with Winners and Whiners.

Creighton is looking to get above .500

Creighton comes into this game on a two-game losing skid after falling at Nebraska 71-50 and Kansas State 83-76. Their overall schedule has been challenging, as they have also lost to Gonzaga, Baylor, and Iowa this season, alongside a win over Oregon on their resume.

Get Free $30 Credit for Premium Picks + Exclusive Discounts

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Winners and Whiners may use third-party services to process my data.

On offense, the Bluejays are averaging 74.6 points per game and are 69th in the country in adjusted efficiency. They are 143rd in the country in effective field goal percentage, but only 213th from three-point range. Josh Dix leads the team at 12.3 points per game and has been elite at the free-throw line, knocking down 93.3% of his attempts.ย  No other Creighton players average double figures, but Blake Harper is next, averaging 9.2 points and a team-high 5.3 rebounds. Nik Graves averages 8.9 ppg and leads the team with 3.2 assists and 1.1 steals per game. Defensively, the Bluejays are 87th in efficiency, but only 340th when it comes to the percentage of turnovers they have been able to force.

Xavier rolling with balance

Xavier is on a five-game winning streak after knocking off arch-rival Cincinnati and Missouri State in their last two games. On the season, the Musketeers are averaging 78.4 points per game, rank 98th in adjusted offensive efficiency, and do an excellent job protecting the ball as they have the lowest turnover percentage in the nation.

Tre Carroll has been the go-to scorer forย  Xaver, pouring in 16.9 points per game while shooting efficiently from the field and three-point range. Filip Borovicanin anchors the frontcourt, leading the team with 7.4 rebounds per game and adding 8.9 ppg. while also contributing as a passer and defender. Defensively, Xavier is solid, holding opponents to 71.5 points per game and ranking 74th in defensive efficiency.

Creighton vs. Xavier Predictions

Creighton vs Xavier ATS Pick:

  • Xavier -2.5 (4 units)

Creighton has faced some difficult competition this season, but lately the team seems to be wearing down instead of improving. ย This will be another tough spot for the Jays, as the Musketeers have won five straight and return to the Cintas Center, where they hold a strong home-court edge. Xavier doesnโ€™t beat itself, and it shows as they are the No. 1 team in the nation in offensive turnover percentage (12.4), and will be facing a Creighton defense that is 339th in defensive turnover percentage (13.9). On the other end, the Musketeers have also done a slightly better job at protecting the ball than the Bluejays have.

I like Xavier at the short number.

Creighton vs Xavier Prediction Pick:

Total Pick:

  • Under 150.5 (4 units)

The Greg McDermott-led Creighton Bluejays are playing at a very slow pace this season, ranking 318th in adjusted tempo. Offensively, Creighton also hasnโ€™t been consistent from three-point range, and defensively, they donโ€™t force many turnovers, which will limit their easy scoring chances against a Xavier team that protects the ball better than anyone. While the Musketeers do prefer to play faster, theyโ€™ve averaged just 72.8 points per game against teams ranked inside the KenPom top 105. This number seems too high for a conference matchup, which should bring out the best effort from both sides. I like the under.

Betting on College Basketball?

BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users โ€“ Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users โ€“ Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Odds Requirements -500
Cashable No

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright ยฉ 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.