DePaul Blue Demons vs. St. John's Red Storm Picks and Prediction for Tuesday, December 16, 2025
It’s a battle of Big East foes on the hardwood as the DePaul Blue Demons take on the #22 St. John’s Red Storm Tuesday night in the Big Apple and we have you covered with our DePaul vs. St. John’s prediction. DePaul downed Wichita State 61-58 on the road in their previous contest Saturday, winning outright as a seven-point underdog. St. John’s cruised to a 91-64 home win over Iona in their previous game Saturday, failing to cover the line as a 27.5-point favorite. In the all-time series between the teams, the Red Storm owns a 35-22 advantage and has won the last seven meetings, including an 82-58 road win in the most recent matchup on February 19. Read more about this DePaul vs. St. John’s prediction! Struggling with handicapping? Try our NCAAB Predictions!
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DePaul Shooting for Road Upset
DePaul won their third straight and their sixth in the last seven games as they took down Wichita State on the road in their previous contest. The Blue Demons improved to 8-3 on the year and look to open Big East play on a positive note. Against Wichita State, DePaul trailed 11-0 less than three minutes into the game and by as many as 14 in the opening half before rallying to take a 36-31 edge at intermission. The Blue Demons took their biggest lead at 51-42 with 11:12 remaining and held on for the win despite scoring just 10 points the rest of the way. DePaul shot 51.1% from the floor, including seven of 17 from three-point range, and benefitted from Wichita State going just 13 of 28 at the free throw line in the game.
The Blue Demons are average on the offensive end of the floor as they put up 77.4 points per game on the year, putting them 189th in the nation in scoring offense. DePaul pulls down 33.7 rebounds per contest (296th) and dishes out 17.2 assists a night this season. The Blue Demons are above average on the defensive end, ranking 70th by allowing 67.8 points per contest. CJ Gunn leads the team and is one of three players averaging in double figures with 14.2 points and 3.5 rebounds per game. NJ Benson (11.3 points, 6.5 rebounds) and Layden Blocker (11.5 points, 3.5 assists) are the most reliable secondary scoring options. Brandon Maclin, Theo Pierre-Justin, Kaleb Banks, RJ Smith, Ilija Milijasevic, Jeremy Lorenz, Kruz McClure and Khaman Maker are other key players for the Blue Demons for coach Chris Holtmann. DePaul shoots 46.1% from the floor as a team this season. The Blue Demons knock down 7.8 triples a night (191st) while connecting on 34.5% (153rd) from beyond the arc. DePaul is below average when it comes to their free throw chances as they sink 70% of their opportunities on the year, leaving them 228th in the nation.
Key Injury Report for DePaul:
- Guard Brandon Maclin (shoulder) is questionable.
- Forward Jeremy Lorenz (undisclosed) is questionable.
Red Storm Looking to Roll at Home
St. John’s won their second straight game as they took down Iona in their previous contest Saturday at home. The Red Storm improved to 6-3 on the season and seek to beat the Blue Demons for the eighth straight time. Against Iona, St. John’s trailed 10-2 early before taking control of the game with an 18-2 run to take a 20-12 advantage with 8:48 to go in the first half. The Red Storm led by 10 at the half and by as many as 27 en route to the win. St. John’s shot 51.7% from the floor, including 10 of 26 from three-point range, and won the rebounding battle 42-31 in the game. Oziyah Sellers led the Red Storm with 19 points as one of six players in double figures in the win.
The Red Storm puts up an average of 88.9 points per game so far this season, putting them 27th in the nation. St. John’s pulls down an average of 40 rebounds per game (64th in the nation) while dishing out an average of 16.4 assists (82nd) per contest. The Red Storm is average on the defensive end of the floor as they are 178th in the nation in scoring defense by allowing 73 points per game. Bryce Hopkins leads the Red Storm and is one of six players averaging in double figures as he puts up 14.9 points and five rebounds per game. Zuby Ejiofor (14.4 points, 7.2 rebounds, 2.7 blocks), Oziyah Sellers (11.9 points, 3.7 rebounds), Ian Jackson (11.7 points), Dillon Mitchell (10.4 points, 6.2 rebounds) and Joson Sanon (10.1 points) are solid scoring options. Dylan Darling, Ruben Prey, Lefteris Liotopoulos and Sadiku Ibine Ayo are all looked at to be contributors for coach Rick Pitino and the Red Storm this season. St. John’s shoots 48.1% from the field as a team this season. The Red Storm knocks down 7.7 triples per game while shooting 34.7% from beyond the arc on the year. St. John’s is slightly above average at the charity stripe, sinking 72.3% of their attempts from the line as a team, leaving them 154th in the nation.
Key Injury Report for St. John’s:
- No Key Injuries
DePaul vs. St. John’s Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Tony Karpinski | +2,494.00 |
| 2 |  Joe Duffy | +1,859.00 |
| 3 |  The Insiders Room | +1,788.00 |
| 4 |  Mark Ruelle | +1,428.00 |
| 5 |  Jackie Mack | +1,400.00 |
DePaul vs. St. John’s Spread Pick
- St. John’s -17.5 (4 units)
DePaul is 8-3 on the year but they’ve played a pretty soft non-conference slate heading into this contest. Five of their wins are against teams ranked in the bottom 20 of the KenPom rankings, while a sixth came over a Detroit Mercy squad ranked 293rd on the year. The Blue Demons dropped their two toughest games, falling by two at home against Northwestern and getting walloped by 33 on a neutral floor by LSU. St. John’s is a ranked team and their losses came to very good squads in Alabama, Iowa State and Auburn. DePaul isn’t at that level and the Red Storm cruises to a win here.
DePaul vs. St. John’s Over/Under Pick
- Under 153 (4 units)
On the season, the Blue Demons have seen the under post a 6-4-1 mark in their 11 games. That includes an under in their lone road contest of the season. DePaul is 81st in defensive efficiency, 61st in effective field goal percentage defense (47.2%) and 45th in forced turnover percentage (20.6%) on the year. The Blue Demons are 204th in adjusted tempo with 68.2 possessions per game. St. John’s is 23rd in offensive efficiency, 18th in free throw rate (.471), 23rd in offensive rebounding percentage (38.7%) and 78th in field goal percentage. The Red Storm pushes the pace, ranking 42nd in adjusted tempo with 71.6 possessions a night. With that said, St. John’s is 15th in defensive efficiency, 40th in effective field goal percentage defense (46%), 28th in forced turnover percentage (21.2%) and 72nd in field goal percentage defense (40.8%) on the year. Look for the Blue Demons to struggle offensively, keeping this game under the number.
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