Indiana State vs. Duke Odds, Preview, Picks, and Prediction for Friday, November 14, 2025
Use Code WWWC On Friday, the Indiana State Sycamores will face the Duke Blue Devils in college basketball action, and we have you ready to go with our Indiana State vs. Duke prediction, odds, and preview. Tip-off from Cameron Indoor Stadium in Durham, NC, is at 7:00 p.m. ET.
Duke is a 36.5-point spread favorite, and the game total is 162.5 points scored.
Indiana State is 2-1 and Duke is 3-0 this season. In their most recent games, the Sycamores beat SIU Edwardsville 64-55 on Monday, and the Blue Devils defeated Army 114-59 on Tuesday. If you want the Indiana State vs. Duke prediction, read on to get our top NCAAB predictions and increase your bankroll!
Indiana State is a program in transition
Indiana State (2-1 SU, 1-1 ATS, and 1-1 O/U) bounced back from its season-opening loss to Charlotte with consecutive victories over Illinois Tech and SIUE. In their latest game, the Sycamores locked in defensively after halftime, holding the Cougars to 23 points. It was a gritty road win and a confidence-booster ahead of Friday's opportunity against Duke.
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Indiana State compiled a 14-18 record last season, including 8-12 in Missouri Valley Conference competition. It was a season of change, as head coach Matthew Graves was in his first season at the helm, taking over for Josh Schertz, who left for Saint Louis University after leading the Sycamores to a 32-7 record and the MVC championship. Graves was the associate head coach under Schertz, making the transition easier. Unfortunately, a health issue recently forced Graves away from the team, making Mark Slessinger the interim coach.
ISU wasn't picked as one of the preseason favorites in the MVC, as the 2025-26 squad was predicted to finish eighth in the 12-team league. They are scoring 81.3 points per game (234th) on 46.7 percent shooting (162nd), including 25.6 percent from beyond the arc (342nd). The Sycamores have struggled at times defensively, giving up 92 points in their season opener, and their opponents are shooting 43.3 percent (16th) with a 36.2 percent mark from three-point range (282nd).
Indiana State is paced by senior forward Ian Scott, who is averaging 14.3 points and 10.0 rebounds on 70.8 percent shooting. The graduate transfer from Grace College is joined by Florida A&M transfer guard Sterling Young (13.0 PPG), junior guard Camp Wagner (9.3 PPG), and a couple of big men in former Central Michigan center Markus Harding (9.3 PPG) and junior center Derek Vorst (10.3 PPG and 4.7 RPG). The 6-foot Young is a three-point threat (40% on five attempts per game), as well as the former Rice sharpshooter Wagner, who shot 38 percent from deep last season.
Indiana State Sycamores Basketball Injury Report: No injuries to report for Friday's NCAAB game versus Duke.
Is this a trap game for the Blue Devils?
Duke (3-0 SU, 3-0 ATS, and 1-2 O/U) overwhelmed Army from the opening tip and didn't relent in the second half, turning a 19-point lead into a 55-point win. The Blue Devils hit 16 three-pointers, scored 31 fast-break points, and added 42 more in the paint. Duke is scoring 95.0 points per game (132nd) on 49.2 percent shooting (97th), including 38.0 percent from beyond the arc (88th). Their opponents are averaging 58.0 points (20th) on 31.2 percent shooting (5th), including 22.6 percent from three-point range (25th).
Duke went 35-4 last season, winning the ACC regular season title (19-1 record) and conference tournament championship before reaching the Final Four of the NCAA Tournament, where the Blue Devils lost to second-ranked Houston. With one-and-done frosh Cooper Flagg, Kon Kneuppel, and Khaman Maluach off to the NBA, head coach Jon Scheyer reloaded with the nation's top recruiting class, but can they go a step further than last season's squad?
The Blue Devils are the favorite to win the ACC in 2025-26, returning six players and welcoming in five freshmen and one college transfer. They return a solid core, with Isaiah Evans, Caleb Foster, Maliq Brown, and Patrick Ngongba II back to complement the team's incoming stars. They didn't lose a single player to the transfer portal, a sigh of relief for Scheyer after he watched five rotation players depart in the spring of 2024. Returnees Evans (6.8 PPG) and Foster (4.9 PPG) will man the backcourt after both averaged roughly 14 minutes per game last season. Foster saw less time on the court than he did as a freshman (25 minutes/game with 15 starts), but he will have ample playing time as the Blue Devils' starting point guard. Evans returned for his sophomore season after considering the NBA Draft, giving the team a lengthy three-point threat at shooting guard.
The headliner of this season's Duke squad is undoubtedly five-star freshman forward Cameron Boozer, who will be in the conversation for the top pick in the 2026 NBA Draft. The skilled son of former Blue Devil and NBA star Carlos, Boozer has the size, athleticism, and skill set to make an impact from the start. He will be joined in the starting lineup by five-star freshman Nikolas Khamenia or Dame Sarr, an international project from Italy, and the senior center Ngongba, who appeared in 30 games off the bench last season. As for the reserves, the senior glue guy Brown and freshman point guard Cayden Boozer are two names to watch.
Duke Blue Devils Basketball Injury Report: No injuries to report for Friday's college hoops game versus Indiana State.
Indiana State vs. Duke Pick and Preview
Spread Pick for Indiana State vs. Duke
- Blue Devils -36.5 (5 Units)
Betting Trend: Duke is 4-1 ATS in its last five games as betting favorites of 30-plus points.
ISU's performance in its first three games hasn't given me a reason to bet against mighty Duke, even with the home team laying 36 points. The Blue Devils are a team I feel comfortable betting in this type of game, as their roster is brimming with future pros, so even the reserves put on a quality show, making the most of their limited minutes. The Dukies are deep and versatile, especially on the wing. They will have a significant advantage in the rebounding department — they rank 21st in total rebounding, while the Sycamores are 237th — and their length will force turnovers leading to transition buckets (ISU is 212th in turnovers per offensive possession and Duke averages 20.7 fast-break points per game). The visitors have a couple of potential three-point threats, but they're undersized guards who will struggle to convert their looks against the Blue Devils (22.6% opponent 3PT%).
Bet on Duke to overwhelm Indiana State with its talent, size, and depth, covering the spread in yet another blowout victory.
Over/Under Pick for Indiana State vs. Duke
- Under 162.5 (4 Units)
The Blue Devils broke the 100-point mark last game and scored 95 in their previous victory, but even if they score 90-plus again, I'm not convinced the Sycamores will put up enough of a fight to push the total over 162. The Blue Devils aren't just an offensive juggernaut; they're also an elite defensive team. They held Texas to 60 points in their season opener and limited their last two opponents to less than 60. They rank 8th nationally in defensive efficiency and 6th in opponent eFG% this season. With a game against Kansas up next on the schedule, it's also possible that Duke takes its foot off the gas late in the second half. There's only so much Scheyer can learn from watching his team destroy an overmatched opponent. The matchup against the Jayhawks will serve as a meaningful measuring stick, especially with non-conference games vs Arkansas, Florida, Michigan State, and Texas Tech after that.
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