Louisville Cardinals vs Duke Blue Devils Picks and Predictions for Monday, January 26, 2026

By: Cameron Ross Published 01/26/2026, 06:45 AM ET
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The Louisville Cardinals will be on the road Monday night for a 7:00 PM matchup in Durham, NC, against the Duke Blue Devils, and we have you ready to roll with our Louisville vs Duke prediction. Louisville is the 23rd-ranked team in the nation, with 14 wins on the year, coming into Monday. Duke stays at home Monday night, with 18 wins and 1 loss this season, ranked #5 in the nation. Louisville comes into Monday having won three of the last four, including two in a row, after a 14-point home victory against Virginia Tech. The Blue Devils stay home Monday night, riding a long winning streak after a 21-point home victory against Wake Forest over the weekend.Read more about this Louisville vs Duke prediction! Struggling with handicapping? Try ourย NCAAB Predictions!

Louisville tries to stay hot

The Louisville offense has carried the team this season, averaging 87.8 points on 47% shooting from the floor. Defensively, the Cardinals are allowing 69.6 points per game this year, and have given up an average of 64 points per game over their last three wins. Offensively, Louisville rolled in its last outing, pouring in 85 points on 47% shooting from the floorย while knocking down 13 triples. Defensively, the Cardinals were the better team, giving up 71 points on 40% shooting from the floor. Louisville won the rebounding battle by 13 and forced 13 turnovers to seal the victory. Mikel Brown Jr. led the way for the Louisville offense in their win against Virginia Tech with 20 points on 11 shots in 29 minutes. Ryan Conwell boasted a second-best 14 points on 11 shots. Jโ€™Vonne Hadley chipped in 14 points and 32 minutes, and Sananda Fru was the third Louisville starter in double digits with 13 points on eight shots.

Ryan Conwell leads the Louisville offense this season, averaging 19.5 points per game. Freshman Mikel Brown is 2nd on the roster, averaging 16.9 points, and Isaac McNeely is third on the team, averaging 11.8 points per game. Sananda Fru averages 10.9 points and leads the team, averaging 7.1 rebounds per game. Jโ€™Vonne Hadley is averaging 10.8 points per game this season. Adrian Wooley has been vital for the Louisville offense this season, averaging 9.6 points in just over 23 minutes per game.

Key Injury Report for Louisville:

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  • Spencer Legg Questionable) - Undisclosed
  • Khani Rooths (Questionable) - Illness

Duke tries to stay on top of the ACC

The Duke Blue Devils are one of the better teams in the country, averaging 85.7 points on 50% shooting from the floor. Defensively, the Blue Devils are allowing 65.3 points per game this season and have given him an average of 64.6 points per game over their last five wins. Defensively, they held their own against Wake Forest, allowing 69 points on 41% shooting. Offensively, the Blue Devils were dominant, pouring in 90 points on 50% shooting and knocking down 7 triples in the game. Duke won the rebounding battle by 21, forcing 9 turnovers in the win. Cameron Boozer led the way for the Duke offense against Wake Forest with 32 points and 9 rebounds on 20 shots in 33 minutes. Big man Patrick Ngongba II added a second-best 13 points, and Isaiah Evans was third on the team with 11 points in 29 minutes. The Duke bench combined to score 21 points between six players.

Cameron Boozer leads the Duke offense this season with 23.7 points, 9.9 rebounds, and 4.1 assists. Isaiah Evans is second on the team, averaging 14.4 points per game this season. Big man Patrick Ngongba II is the third Duke player this season in double digits, averaging 11 points per game. Caleb Foster averages 8.9 points in just over 25 minutes per game this season. Cayden Boozer is 5th on the Duke roster this season, averaging 6.5 points in just over 20 minutes per game.

Key Injury Report for Duke:

  • Ifeanyi Ufochukwu (Out) - Undisclosed
  • Sebastian Wilkins (Out) - Redshirt

Louisville vs Duke Pick

  • Louisville vs Duke Spread Pick

Both teams come into this game playing great basketball as of late, each looking to stay atop the ACC. Look for Duke, however, to do the job on both sides of the ball as their size and depth will be the difference. The Blue Devils are rolling as of late and will look to keep that momentum going as they push to retain the top spot in the ACC. Expect a back-and-forth affair as two potent offenses square off Monday night in ACC play. Take Duke to get the winning cover at home to continue their winning streak against a good Louisville team.

  • Louisville vs Duke Over/Under Pick

Both teams are strong on defense, and both have elite offenses that will shine in this matchup. Expecting a back-and-forth affair as points come in bunches throughout Monday night's contest. Louisville will find its spots, but Duke will control this game down the stretch, leading to the victory. Take both teams to score a ton of points as the total goes over in what will be a Duke win and cover at home.

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