LSU Tigers vs Ole Miss Rebels Picks, Prediction, Odds, and Line Movement for Wednesday February 25 2026

By: Kyle Kargel Published 02/25/2026, 08:50 AM ET
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LSU vs Ole Miss picks take center stage in Oxford as two SEC teams try to stop the bleeding. If you are grinding through college basketball picks looking for value, this one is tricky but playable. Both sides are sliding, but the betting market is telling a clear story with this short number.

Quick Picks and Prediction

  • Spread Pick: LSU +1.5
  • Total Pick: Over 148.5
  • Projected Final Score: LSU 75, Ole Miss 73

Odds and Line Movement

Opening Odds

Market LSU Mississippi
Spread +1.5 (-110) -1.5 (-110)
Market Over Under
Total 146.5 (-110) 146.5 (-110)

Current Odds

Market LSU Mississippi
Spread +1.5 (-110) -1.5 (-120)
Market Over Under
Total (148.5) 148.5 (-108) 148.5 (-112)

Line Movement - Spread

Date Time LSU Mississippi
02/24 04:25:34PM +1.5 (-110) -1.5 (-110)
02/24 03:23:59PM +1.5 (-102) -1.5 (-120)

Line Movement - Total

Date Time Over Under
02/25 04:59:56AM 148.5 (-108) 148.5 (-112)
02/25 12:52:53AM 147.5 (-110) 147.5 (-110)
02/24 03:23:59PM 146.5 (-110) 146.5 (-110)

LSU vs Ole Miss Key Matchups and Handicap

There is real pressure on Matt McMahon in Baton Rouge. LSU looks headed toward missing the NCAA Tournament for a fourth straight year under his watch. The preseason message from the athletic department was clear. A Big Dance invite was expected. That has not materialized.

The biggest blow came in late January when point guard Dedan Thomas Jr went down for the season with a foot injury. He was the engine of this team, averaging 15.3 points per game and 6.5 assists per game, the top mark in the SEC. LSU was 12 and 4 with him in the lineup and just 2 and 9 without him. That split says everything.

Still, the Tigers have been competitive. They have covered eight of their last 12 games and their only recent spread loss on the SEC trail came at Florida. In the absence of Thomas, Marquel Sutton has stepped up. The former Omaha guard is averaging 18 points per game across the last six contests, giving LSU a steady scoring option.

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Ole Miss might be in even worse shape. The Rebels have dropped nine in a row. All but two of those losses have come by nine points or more. Chris Beard has a roster full of portal adds, freshmen, and international pieces, but it has not meshed. Bench production has been limited and the team has not won since mid-January.

AJ Storr has mostly delivered at 14.8 points per game, but he has not had enough help. The Rebels have covered just one of their last six games and look stuck in reverse. In a matchup between two struggling teams, I lean toward the one that has at least been fighting at the window.

The total has climbed from 146.5 to 148.5. That tells me the market expects points despite both teams sliding. With Sutton’s recent scoring surge and Ole Miss desperate to snap the skid, I see a game that pushes into the mid-70s on both sides.

  • LSU was 12 and 4 with Dedan Thomas Jr in the lineup and is 2 and 9 without him.
  • LSU has covered eight of its last 12 games.
  • Ole Miss has lost nine straight games.
  • Ole Miss has covered just one of its last six games.
  • The total has moved from 146.5 to 148.5.

Key Injuries and Notes - LSU and MISS

  • LSU: Dedan Thomas Jr is out for the season with a foot injury.
  • LSU: Marquel Sutton is averaging 18 points per game over the last six games.
  • MISS: AJ Storr is averaging 14.8 points per game.
  • Ole Miss has not won since mid-January.

ATS and Total Picks

  • ATS Pick: LSU +1.5
  • Total Pick: Over 148.5

Final Score Prediction

This shapes up as a tight SEC battle between two teams searching for momentum. I trust LSU’s recent competitiveness more than Ole Miss’s extended slide.

  • Projected Final Score: LSU 75, Ole Miss 73

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