Marquette at Creighton Prediction, Picks, and Odds Movement for December 20, 2025

By: Kyle Kargel Published 12/20/2025, 08:26 AM ET
Use Code WWWC

Marquette vs Creighton picks headline Saturday night in Omaha as one of the Big East’s most compelling rivalries renews, and this matchup is firmly on the radar for bettors scanning college basketball picks and college basketball predictions. With Creighton opening conference play at home and Marquette searching for answers, this spot offers a clear contrast in form, confidence, and execution.

Quick Picks and Prediction

  • Spread Pick: Creighton -9.5
  • Total Pick: Over 147.5
  • Projected Final Score: Creighton 82, Marquette 71

Odds and Line Movement

Opening Odds

Team Spread Total
Marquette +9.5 147.5
Creighton -9.5 147.5

Current Odds

Team Spread Total
Marquette +9.5 (-105) Over 147.5 (-110)
Creighton -9.5 (-115) Under 147.5 (-110)

Line Movement - Spread

Date Time Marquette Creighton
12/19 01:06PM +9.5 (-105) -9.5 (-115)
12/19 01:05PM +9.5 (-106) -9.5 (-114)
12/19 12:41PM +9.5 (-102) -9.5 (-120)

Line Movement - Total

Date Time Over Under
12/19 12:41PM 147.5 (-110) 147.5 (-110)

Marquette vs Creighton Key Matchups and Handicap

This game sets up as a clash between Creighton’s offensive rhythm at home and a Marquette team still searching for consistency. The Bluejays come in off a dominant 98-57 win over Xavier, a performance that showcased just how dangerous this offense can be when the perimeter shots are falling. Creighton shot over 60 percent from the field and knocked down 16 three-pointers, stretching the floor and forcing constant defensive rotations.

Marquette’s recent struggles have been tied to offensive inefficiency. In their Big East opener against Georgetown, the Golden Eagles managed just 69 points and saw leading scorer Chase Ross limited to four points on poor shooting. That type of output puts enormous pressure on Marquette’s defense, especially on the road in a hostile environment like CHI Health Center Omaha.

Creighton’s ability to generate clean perimeter looks is the defining matchup edge. Even without some frontcourt depth, the Bluejays have shown they can overwhelm opponents with spacing, ball movement, and shot confidence. Marquette’s defensive lapses away from home suggest they may struggle to keep Creighton out of rhythm for long stretches.

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Pace also favors a higher-scoring game. Both teams are comfortable playing quickly, and if Creighton establishes early momentum, Marquette will be forced to chase the game offensively. That script generally benefits the home favorite and pushes the total upward.

  • Creighton is coming off a blowout win and enters its Big East home opener with momentum.
  • Marquette has dropped its conference opener and has struggled to score efficiently on the road.
  • Creighton’s recent offensive output points toward higher-scoring game environments.

Key Injuries and Notes for MARQ and CREI

  • CREI: Jackson McAndrew is out for the season with a foot injury.
  • CREI: Hudson Greer is out with a foot issue.
  • MARQ: No major injuries reported.

ATS and Total Picks

  • Against the Spread: Creighton -9.5
  • Total: Over 147.5

Final Score Prediction

Creighton 82, Marquette 71

How to Bet on Marquette vs Creighton

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