Missouri State vs Xavier Picks and Predictions For December 12, 2025

By: Kyle Kargel Published 12/12/2025, 11:27 AM ET
Use Code WWWC

Missouri State heads to Cincinnati to take on Xavier in a non conference matchup that offers value for bettors tracking college basketball picks. Xavier enters with momentum after a rivalry win, while Missouri State continues to search for answers on both ends of the floor.

Quick Picks and Prediction

  • Spread: Xavier -18
  • Total: Over 148
  • Projected Final Score: Xavier 86, Missouri State 62

Odds and Line Movement

Opening Odds

Team Spread Total
Missouri State +16.5 (-105) Over 144.5 (-115)
Xavier -16.5 (-115) Under 144.5 (-105)

Current Odds

Team Spread Total
Missouri State +18 (-110) Over 148 (-110)
Xavier -18 (-110) Under 148 (-110)

Line Movement - Spread

Date Time Missouri State Xavier Public
12/12 08:25AM +18.5 (-110) -18.5 (-110) Xavier 83%, 50%
12/11 10:57PM +18.5 (-110) -18.5 (-110) Xavier 83%, 50%
12/11 01:31PM +16.5 (-105) -16.5 (-115) Xavier 83%, 50%

Line Movement - Total

Date Time Over Under
12/12 09:18AM 148 (-110) 148 (-110)
12/11 05:46PM 145 (-110) 145 (-110)
12/11 01:31PM 144.5 (-115) 144.5 (-105)

Xavier

The Richard Pitino era in Cincinnati is beginning to pick up some momentum. After a rocky start that featured losses to Santa Clara, Iowa and Georgia, Xavier has won four straight. This will be the Musketeersโ€™ first game since beating rival Cincinnati 79-74 last Friday.

Senior forward Tre Carroll finished with 30 points and seven rebounds against the Bearcats, continuing a strong stretch for a Xavier offense that has steadily improved as Pitino has settled on his rotation.

Missouri State

Things have not been going nearly as smooth in Springfield where Cuonzo Martin is struggling in his second season with the Bears. Missouri State only has one win over a Division I program this season and is coming off a 24 point loss to Tulsa.

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Missouri State is outside the top 250 in both offensive and defensive efficiency. Tulsa is the only top 100 opponent the Bears have faced so far, and that matchup exposed many of Missouri Stateโ€™s current limitations.

Key Matchups and Handicap

We are interested in the over in this contest. Xavier has picked up the pace in recent weeks as Pitino has figured out how to best use his lineup. The Musketeers played at a very slow pace early in the season, but their last three games against Texas AandM Corpus Christi, Saint Francis and Cincinnati featured 75, 78 and 74 possessions.

This will be Xavierโ€™s fourth straight home game, which should help the Musketeers remain comfortable with the shooting backdrop at the Cintas Center. Missouri State did shoot 13 of 26 from three point range against Tulsa, so the Bears are capable of knocking down perimeter shots.

Xavier has covered the spread during its current four game winning streak, while Missouri State has struggled to remain competitive against quality opponents. Recent Xavier games have trended toward higher possession counts.

MSU and XAV Key Injuries and Notes

Both teams enter this matchup without any major lineup changes impacting rotation stability.

ATS and Total Picks

  • Xavier -18
  • Over 148

Final Score Prediction

Xavier 86, Missouri State 62

How to Bet Missouri State vs Xavier

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