Northwestern Wildcats vs. DePaul Blue Demons Picks and Prediction for Friday, November 14, 2025
Use Code WWWC It’s an early-season clash on the hardwood, and it brings a non-conference tilt between foes from the Big Ten and the Big East on the hardwood in the Windy City as the Northwestern Wildcats take on the DePaul Blue Demons Friday night, and we have you covered with our Northwestern vs. DePaul prediction. Northwestern cruised to a 110-63 win at home over Cleveland State in their previous contest Monday night, covering the line as a 23-point favorite. DePaul fell 66-53 at home to Buffalo in their previous contest on Tuesday, losing outright as an 18.5-point favorite. In the all-time series between the teams, the Wildcats own a 7-2 advantage and have won the last three meetings, including an 84-64 triumph at home in the most recent matchup on December 21, 2024. Read more about this Northwestern vs. DePaul prediction! Struggling with handicapping? Try our NCAAB Predictions!
Northwestern Seeking to Maintain Momentum in First Road Tilt
Northwestern cruised to a one-sided win over Cleveland State in their previous game to remain unbeaten on the young season. The Wildcats improved to 3-0 on the year and look to carry that momentum on the road as they make the in-state trek here. Against Cleveland State, Northwestern only trailed once in the game at 6-5, then scored the next 10 points, and they were off and running from there. The Wildcats were up 53-28 at the half and led by as many as 52 en route to the blowout victory. Northwestern shot a blistering 60.3% from the floor, including 11 of 21 from beyond the arc, and controlled the glass by a 40-27 margin. Nick Martinelli paced the Wildcats with 21 points and seven rebounds in the win as one of five players in double figures.
The Wildcats enter this contest 126th in scoring offense by putting up 85.3 points per game on the year. Northwestern is collecting an average of 41.7 boards a night while ranking 39th by dishing out 19.7 assists a game. The Wildcats are good on the defensive end of the floor, ranking 8th in scoring defense as they allow 54 points per contest. Nick Martinelli leads the Wildcats offensively as he puts up 19.3 points and seven rebounds per game. Arrinten Page (14 points, 9.3 rebounds, 2.3 assists), Jayden Reid (10.3 points), and Justin Mullins are good secondary scoring threats. Tre Singleton, Angelo Ciaravino, Max Green, K.J. Windham, Jake West, Tyler Kropp, Phoenix Gill, and Jordan Clayton are capable rotation pieces for Northwestern this season. The Wildcats shoot 50.6% from the field on the season. Northwestern knocks down 7.7 triples per game while shooting 39% from beyond the arc, leaving them 62nd in the nation. The Wildcats have been slightly below average at the free-throw line, converting 69.9% of their chances at the line this season, leaving them 206th in that department.
Blue Demons Trying to Bounce Back After Loss
DePaul opened the year with two straight wins but ended up flat as they were surprised by Buffalo at home in a game where they were a hefty favorite. The Blue Demons dropped to 2-1 on the year and try to get back on track here. Against Buffalo, DePaul took their last lead at 4-2 three minutes into the game as they were cold from the floor all night long. The Blue Demons found themselves down 36-18 at the half and got within two at 50-48 with 5:43 remaining, only to give up an 8-1 run over the next three minutes to seal their fate. DePaul shot just 33.3% from the floor, including nine of 25 from beyond the arc, missed half of their 20 free throw attempts and turned the ball over 20 times. NJ Benson had 11 points and eight rebounds as the lone player in double figures for the Blue Demons in the loss.
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The Blue Demons are below average on the offensive end of the floor as they put up 72.3 points per game on the year, putting them 276th in the nation in scoring offense. DePaul pulls down 40.3 rebounds per contest (130th) and dishes out 16 assists a night this season. The Blue Demons are above average on the defensive end, ranking 65th by allowing 64 points per contest. CJ Gunn leads the team and is one of two players averaging in double figures with 15.7 points and 4.3 rebounds per game. NJ Benson (14.3 points, 9.3 rebounds) and Layden Blocker are the most reliable secondary scoring options. Brandon Maclin, Theo Pierre-Justin, Kaleb Banks, RJ Smith, Ilija Milijasevic, Jeremy Lorenz, Kruz McClure, and Khaman Maker are other key players for the Blue Demons under coach Chris Holtmann. DePaul shoots 40.5% from the floor as a team this season. The Blue Demons knock down 7.3 triples a night (214th) while connecting on 29.7% (264th) from beyond the arc. DePaul is below average when it comes to their free throw chances as they sink 61.1% of their opportunities on the year, leaving them a dismal 336th in the nation.
Northwestern vs. DePaul Pick
Northwestern vs. DePaul Spread Pick
- Northwestern -5.5 (4 units)
Sure, Northwestern is on the road for the first time this season, but the Wildcats have been good offensively so far. Hanging 110 points on Cleveland State while shooting the ball as well as they did shows that Northwestern has the potential to make things tough for opposing teams. We saw DePaul struggle mightily against Buffalo, who is a team that is projected to be in the lower rungs of the MAC. Shooting 33.3% from the field, at home, against a struggling mid-major, doesn’t instill much in the way of confidence, especially when you’re facing a power conference team that is clicking. Northwestern has beaten DePaul three straight times and they make it four by prevailing here.
Northwestern vs. DePaul Over/Under Pick
- Under 139.5 (4 units)
Both teams come into this game having stayed under the total in two of their three games on the season. Northwestern ranks 24th in defensive efficiency, 16th in effective field goal percentage defense (39.9%), 89th in forced turnover percentage (20.8%) and 18th in field goal percentage defense (34.3%) on the year. The Wildcats are 310th in adjusted tempo with 69.4 possessions a night. DePaul is 76th in defensive efficiency, 75th in effective field goal percentage defense (44.8%) and 96th in forced turnover percentage (20.3%) on the year. The Blue Demons are 167th in adjusted tempo with 71.5 possessions per game. This game is more defensively oriented and winds up short of the number as a result.
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