Notre Dame vs. North Carolina Picks and Predictions, Wednesday, January 21st. 2026

By: Paul B Published 01/21/2026, 06:40 AM ET
Notre Dame vs. North Carolina Prediction
Use Code WWWC

The Notre Dame Fighting Irish (10-8) and the #22 North Carolina Tar Heels (14-4) will battle in an ACC matchup on Wednesday night in this Notre Dame vs. North Carolina prediction. The Fighting Irish are coming off an 89-76 loss on the road in Virginia Tech, missing the cover as 6.5 point underdogs. UNC just lost at Cal, falling 84-78 as 7.5-point favorites. Tipoff is set for 7:00 EST and can be found on ESPN2. Keep reading to see our Notre Dame vs. North Carolina prediction,Β and keep up with all of our best NCAAB Betting Picks!

Notre Dame Starts Slow in the ACC

The Notre Dame Fighting Irish play in the ACC in college basketball, unlike their football team on campus. Unfortunately for the Irish, they have gotten out to a slow start in conference play, as they lost four of their first five games in ACC play. Their last three losses have all come by ten or more points, and they will look to pull a big upset here in Chapel Hill.

In their last game against Virginia Tech, they were led by Brady Koehler off the bench with 17 points in the loss. He is a 6'10 freshman who is working to improve his inside-out game, but is only averaging 4.4 PPG on the season. Notre Dame has been without their top scorer, as Markus Burton was scoring 18.5 PPG before coming out of the lineup with an injury in early December. This makes 6'7 freshman Jalen Haralson their top scorer, he is getting 14.7 PPG and 3.5 RPG while playing an inside out game.

Notre Dame is currently ranked 75th out of 365 Division I teams according to KenPom.Β  They are 107th in offensive efficiency and 55th in defensive efficiency. They play at a very slow pace, ranking 305th in the country in pace of play.

Get Free $30 Credit for Premium Picks + Exclusive Discounts

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Winners and Whiners may use third-party services to process my data.

Tar Heels Drop Three of Four

One of these ACC teams will get back on track, as the North Carolina Tar Heels have lost three of their last four, and look to grab a home win here over the Irish. They dropped two consecutive games out West against Cal and Stanford, and also fell against SMU while mixing in a win against Wake Forest. In their last game, they were led by Caleb Wilson with 17 points in the loss to California.

Wilson looks like he will be a future NBA player, as the freshman is one of the top prospects in the country. Wilson is a 6'10 forward leading the team with 19.7 PPG and 10.6 RPG, he has an old school post game as he has only made four three-pointers all season. Wilson has scored 17 or more in each of his last three games. Henri Vesaar is another elite post prospect for UNC, he is a 7'0 junior out of Estonia getting 17.2 PPG and 9.1 RPG. Their final scorer in double figures is Seth Trimble, a veteran guard scoring 15.0 PPG.

North Carolina is ranked 36th overall according to KenPom. They are 36th in offensive efficiency and 53rd in defensive efficiency. They play faster than Notre Dame, ranking 169th in tempo.

Key Injuries for Notre Dame vs. North Carolina:

Notre Dame

  • Out: Markus Burton

North Carolina

  • None listed

Notre Dame vs. North Carolina Picks and Predictions

Spread pick for Notre Dame vs. North Carolina

  • North Carolina -11.5 (5 units)

This game is when the water will rise back to the skill level, as North Carolina is loaded with talent, and Notre Dame is without their star point guard. The Irish could have kept this close if Burton was in the game, but without their 17 PPG scorer on the perimeter, they will not have enough fire power to compete with the Tar Heels. Even more importantly, UNC is huge inside with two future NBA players, they will control the paint and get an easy win here.

Take UNC to win and cover.

Over/Under Pick for Notre Dame vs. North Carolina

  • Over (4 units)

North Carolina will put on a show here, running up a big number for their team, and pushing this number way over the total. North Carolina has gone over the total in five of their last six, and will smell blood in the water in this game, which will allow them to play fast and create a quick tempo game. Notre Dame typically plays slow, but they will not have the option to dictate tempo here, and will have to try to score quickly to keep up with North Carolina, expect a high scoring game here.

Take the over.

Betting on College Basketball?

BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Odds Requirements -500
Cashable No

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright Β© 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.