Ohio Bobcats vs. Louisville Cardinals Picks and Prediction for Saturday, November 15, 2025

By: Chris King Published 11/15/2025, 12:37 AM ET
Ohio vs. Louisville Prediction
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Itโ€™s an early-season clash on the hardwood, and it brings a non-conference tilt between foes from the MAC and the ACC on the hardwood in the Bluegrass State as the Ohio Bobcats take on the #12 Louisville Cardinals Saturday afternoon, and we have you covered with our Ohio vs. Louisville prediction. Ohio was trounced 90-60 at Saint Maryโ€™s in their previous game Tuesday night, failing to cover the line as an 18-point underdog. Louisville downed #9 Kentucky 96-88 at home Tuesday night, covering the line as a six-point favorite, in their previous game. In the all-time series between the teams, the Cardinals own a 10-3 advantage and have won the last three meetings, including a 59-54 home win in the most recent matchup on November 25, 2011. Read more about this Ohio vs. Louisville prediction! Struggling with handicapping? Try our NCAAB Predictions!

Ohio Trying to Pick Up Road Victory

Ohio was clobbered on the road by Saint Maryโ€™s in their previous contest and return to the eastern time zone hoping to get back in the win column here. The Bobcats enter this game 1-2 on the season and look to get back on track here. Against Saint Maryโ€™s, Ohio led 9-4 early but gave up the next 11 points to trail 15-9 and never got even the rest of the way. The Bobcats were down 45-27 at intermission and trailed by as many as 30 en route to the one-sided defeat. Ohio shot 37.5% from the field, including six of 24 from three-point range, and lost the rebounding battle 40-29 in the game. Jackson Paveletzke led the Bobcats with 19 points in the loss.

The Bobcats come into this game 278th in the nation in scoring offense with an average of 72.3 points per game. Ohio is weak in the rebounding department as they collect 29.7 boards per contest (347th) and are handing out 12 assists a night. The Bobcats are below average defensively as they are 303rd in the nation by holding opposing teams to 82.3 points a game. Aidan Hadaway is one of four players averaging in double figures on the team with 15.3 points plus 5.7 rebounds per game this season. Javan Simmons (14 points, 3.3 rebounds), Jalen Breath (10 points, three rebounds) and Jackson Paveletzke (18 points, four assists) are solid secondary scoring options. Ayden Evans, Dior Conners, Elijah Elliott, Ajay Sheldon, Kiir Kuany, JJ Kelly, Jesse Burns and Jordan Fisher are other rotation pieces that Jeff Boals looks to in order to contribute solid minutes. The Bobcats are shooting 45.6% from the field so far this season. Ohio drills five three-pointers a night while sinking 25.9% from beyond the arc. The Bobcats are below average at the charity stripe as they hit 64.3% of their chances this season, putting them 296th in the nation.

Cardinals Shooting for 4-0 Start

Louisville comes in off an early season marquee win as they outgunned #9 Kentucky in their previous contest Tuesday night. The Cardinals improved to 3-0 on the year and look to remain unbeaten on the season. Against Kentucky, Louisville trailed 22-19 in the first half but took control with a 13-0 run to go up 32-22 with 7:51 before intermission and led the rest of the way. The Cardinals were up seven at the half and led by as many as 20 in the second half en route to the win. Louisville shot 44.9% from the field, including 13 of 40 from three-point range, and forced 14 Kentucky turnovers in the game. Mikel Brown Jr. led the Cardinals with 29 points in the win.

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The Cardinals enter the game 13th in scoring offense with 102 points per contest this season. Louisville is 37th in the nation in rebounding with 45.3 per contest, while the team is 13th in Division I by dishing out 22.3 assists per contest. The Cardinals are above average defensively, ranking 119th in scoring defense as they allow an average of 67.7 points per game this year. Mikel Brown Jr. is leading the team with 19.3 points plus 6.7 assists per game this season. Ryan Conwell (18.3 points, four rebounds), Khani Rooths (12 points, 5.7 rebounds) and Isaac McKneely (11.3 points, three rebounds) are good secondary options offensively. Jโ€™Vonne Hadley (11 points, 8.5 rebounds), Sananda Fru (10.3 points, 6.7 rebounds), Adrian Woolley, Kobe Rodgers, Vangelis Zougres, Kasean Pryor and Aly Khalifa are other contributors for coach Pat Kelsey. Louisville shoots an even 50% from the floor as a team this season. The Cardinals are splashing 11.7 triples a night while shooting 33.3% from beyond the arc. Louisville has been above average at the charity stripe in their attempts by cashing in 73.7% of their attempts this season.

Ohio vs. Louisville Pick

Ohio vs. Louisville Spread Pick

  • Louisville -30 (5 units)

Sometimes, when it comes to putting your money down, you donโ€™t have to sit and overanalyze everything. There are those times when the obvious answer is the right one. We just saw Ohio get drubbed by 30 points while giving up 90 points to a Saint Maryโ€™s team that plays at one of the slowest paces in the nation. Now they have to face a Louisville squad that is averaging 102 ppg, in their own barn, with a world of momentum after dropping Kentucky earlier in the week. The Cardinals have depth, talent and a slew of weapons. They batter Ohio in every facet of the game and win this one in a rout.

Ohio vs. Louisville Over/Under Pick

  • Over 174 (4 units)

Ohio has gone over the total in two of their three games on the season. The Bobcats are 269th in effective field goal percentage defense (55.3%), 302nd in field goal percentage defense (47.2%), 268th in two-point defense (53.3%), 308th in threes allowed per game (9.7) and 324th in three-point defense (38.7%) on the year. Ohio is 92nd in adjusted tempo with 72.8 possessions per game. Louisville has seen the over post a 2-1 mark on the year. The Cardinals are second in offensive efficiency, 40th in effective field goal percentage (58.8%), 61st in turnover percentage (14%), 96th in offensive rebounding percentage (35.7%) and seventh in two-point shooting (68.8%) on the year. Louisville is 26th in tempo with 74.4 possessions a night. Look for the Cardinals to run and gun all over the place, cracking the century mark to push this over the total.

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