Oklahoma State vs. Northwestern, Picks, Odds, Preview, and Prediction, Thursday, November 27, 2025
It’s a key non-conference game in the Windy City on Thursday, Nov. 27. Read our Oklahoma State vs Northwestern prediction along with our NCAAB picks for the night. It’s the CBS Sports Thanksgiving Classic in Chicago, Illinois. Oklahoma State comes into this game with a 6-0 record, with this being their first away game of the season. The Cowboys have picked up key wins over Texas A&M and South Florida, as Oklahoma State is receiving votes in the AP Poll. It’s a short trip for Northwestern to the United Center. The Wildcats are 5-1, and they have secured a big non-conference win over South Carolina last week. These two teams will meet with tip-off set for 10:30 P.M. EST.
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Oklahoma State undefeated to start the season
Oklahoma State is 6-0 overall this season. The Cowboys are receiving votes in the latest AP Poll as they have passed every test so far in the opening month. Oklahoma State’s early schedule has been highlighted by wins over Texas A&M and South Florida. Every game has been at home for the Cowboys, too.
In their last game, Oklahoma State defeated Nicholls 95-81 at home on Saturday, Nov. 22. The Cowboys never trailed in the game as they shot 53% from the field and 40% from behind the arc. Oklahoma State outscored the Colonels 46-36 inside the lane. Jaylen Curry led the team with 30 points from the bench as he shot 8-for-11 from the field.
Vyctorius Miller leads the team with 17.5 points per game. Parsa Fallah is grabbing a team-leading 5.5 rebounds while Kanye Clary is passing for 5.0 assists per game.
Oklahoma State is the No. 55-ranked team in the nation according to KenPom. They are placed 70th in offensive rating and 60th in defensive rating.
Oklahoma State is averaging 93.3 points per game, which ranks 92nd in the nation. They are shooting 49.7% from the field, placing them 50th. The Cowboys are hitting 33.8% from behind the 3-point line which ranks 177th.
On defense, Oklahoma State is allowing 74.3 points per game, which ranks 123rd. They are the 58th-ranked defensive team, allowing 38.8% from the field. The Cowboys are the 70th-ranked 3-point defensive team, giving up 29.2% from deep.
Oklahoma State is 3-3 against the spread this season. They have played every game at home so far this year. They are 2-3 against the spread when they have been favored. The Cowboys are 1-0 against the spread as a single-digit favorite. They are also 1-0 against the spread as an underdog. The under is 4-2 when Oklahoma State has played. The under is 3-1 when the total has been set at 165 or higher.
Northwestern earns close win over South Carolina
Northwestern is 5-1 overall this season. They started with four straight wins, highlighted by a win over DePaul on the road. They followed it with a 5-point loss to Virginia and a 2-point win against South Carolin, with both games being played on a neutral court.
In their last game, Northwestern defeated South Carolina 79-77 in the Greenbrier Tip-Off on Sunday, Nov. 23. South Carolina went on a 9-0 run to tie the game at 75 in the final minute of the game. Nick Martinelli and Arrinten Page both hit big baskets in the final seconds to seal the win. Northwestern shot 57% from the field and 50% from behind the arc. The Wildcats outscored South Carolina 44-32 in the lane. Martinelli led the team with 25 points on 8-for-17 shooting from the field.
Nick Martinelli is leading the team in scoring with 19.3 points per game. Arrinten Page is the top rebounder with 7.0 boards while Jayden Reid is passing for 6.2 assists per game.
Northwestern is the No. 48-ranked team in KenPom’s rankings. They are the 50th-ranked offensive rating team and 69th in defensive rating.
Northwestern is averaging 98.8 points per game, which ranks 47th. They are hitting 51.9% from the field, which ranks 20th best. They are the 13th-best 3-point shooting team, making 41.9% from behind the arc.
On defense, Northwestern is allowing 80.2 points per game, placing them 194th. They are allowing 38.1% from the field, ranking 40th. The Wildcats are the 51st-ranked 3-point defensive team, giving up 28.2% from behind the arc.
Northwestern is 3-3 against the spread this season. They are 1-2 against the spread when playing away from home. The Wildcats are 1-0 against the spread as an underdog. They are also 0-2 against the spread when playing as a single-digit favorite. The over is 4-2 when Northwestern has played. The over is 3-0 when they have played away. The over is 3-0 when they’ve been a single-digit favorite or underdog.
Oklahoma State Cowboys vs Northwestern Wildcats Picks
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vincilleti | +1,778.00 |
| 2 |  Ross Benjamin | +1,716.00 |
| 3 |  David Hess | +1,326.00 |
| 4 |  Earle Sports Bets | +1,323.00 |
| 5 |  Dan Kaiser | +1,071.00 |
Oklahoma State vs Northwestern Spread Pick
- Oklahoma State +2.5 (5 units)
This is going to be a really close game between two teams needing non-conference victories to help their resume come tournament time in March. Northwestern has played two tough back-to-back opponents in Virginia and South Carolina. The Wildcats' high-powered offense is averaging over 95 points per game, but they will have a stern test against a good Oklahoma State defense. The Cowboys are ranked 60th in defensive rating according to KenPom. Oklahoma State has the pieces to secure an outright win with Vyctorius Miller being able to score from anywhere on the court. Oklahoma State’s defense, along with their ranking 50th in field goal shooting, will give the Cowboys the win.
Take Oklahoma State to cover.
Oklahoma State vs Northwestern Over/Under Pick
- Over 160.5 (5 units)
This is a game that will feature conflicting styles. Oklahoma State is the fourth fastest team in the NBA in adjusted tempo according to KenPom. Northwestern ranks 277th in adjusted tempo, but the Wildcats do rank 47th in scoring, averaging 98.8 points per game. Oklahoma State’s speed will allow many chances for them to score, while Northwestern’s efficiency will also provide them a lot of points. The over is 3-0 when Northwestern has been a single-digit favorite.
Take the over on Thursday.
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