Ole Miss Rebels at NC State Wolfpack, Picks, Odds, Preview, and Prediction, Sunday, December 21, 2025

By: Liam Keating Published 12/21/2025, 09:18 AM ET
Ole Miss vs. NC State prediction
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It’s a big non-conference game on a neutral court on Sunday, Dec. 21. Read our Ole Miss vs NC State prediction along with our NCAAB picks for the night. The Rebels are 7-4 and they have won back-to-back games coming into this matchup. Ole Miss is coming off a big win over Alabama A&M. NC State is 8-4 and they have won three of their last four games. Both teams have struggled against top-tier games. They both are under .500 against Power-Five opponents. These two teams will meet with tip-off set for 1 P.M. EST.

Ole Miss winners of back-to-back games

Ole Miss is 7-4 overall this season. After losing four straight losses, the Rebels have won back-to-back games. The four losses have come against Power-Five teams, while the rest of the team’s wins have come against mid-major opponents.

In their last game, the Rebels defeated Alabama A&M 80-66 on Wednesday, Dec. 17. Ole Miss went wire-to-wire in the win as they shot 54% from the field and 44% from behind the 3-point line. The Rebels out rebounded the Bulldogs 33-30, while they also scored 14 points off of 11 turnovers. Malik Dia led the team with 27 points on 9-for-19 shooting.

Dia leads the team with 14.2 points and 6.4 rebounds per game. Ilias Kamardine is passing for a team-leading 4.6 assists per game, too.

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Ole Miss is the 58th ranked team in the nation according to KenPom. The Rebels are the 73rd ranked offensive team and the 59th ranked defensive team in the league.

Ole Miss is averaging 82.9 points per game, which ranks 164th. They are the 170th ranked shooting team, making 45.7% from the field. The Rebels are hitting 35.6% from behind the 3-point line.

On defense, Ole Miss is allowing 74.6 points per game, which ranks 156th. They are the 99th ranked defensive team allowing 41.6% from the field. The Rebels are giving up 33.6% from behind the 3-point line, which ranks 221st .

Ole Miss is 2-8 against the spread this season. The Rebels are 1-3 against the spread when they have played away from home. They are 1-1 against the spread as an underdog. The over is 7-3 when Ole Miss has played this season. The over is 3-1 when Ole Miss has played on the road or neutral site. The over is 6-2 when the total has been set at 149 or below.

NC State coming off big win

NC State is 8-4 overall this season. The Wolfpack have won three of their last four games coming into this game. They are 1-3 against the spread when playing away from home. The Wolfpack are 0-4 when they have played against Power-5 conference foes.

In their last game, the Wolfpack defeated Texas Southern 108-72 at home on Wednesday, Dec. 17. NC State went wire-to-wire for the win as it was an easy win for NC State. The Wolfpack shot 51% from the field and 43% from behind the 3-point line. They forced 13 turnovers, which led to 21 points for the team. Paul McNeil Jr. led the team with 47 points on 12-for-18 shooting.

Darrion Williams leads the team with 16 points per game. Ven-Allen Lubin is grabbing 7.2 rebounds and Quadir Copeland is passing for a team-high 5.5 assists per game.

NC State is the 30th ranked team in the nation according to KenPom. The WolfPack is the 18th ranked offensive team in the nation while they are also 56th in defensive rating.

NC State is averaging 89.3 points per game, which ranks 58th in the nation. They are the 51st best shooting team, hitting 49% from the field. The Wolfpack is hitting 38.9% from behind the 3-point line, which ranks 21st best in the nation.

On defense, NC State is allowing 73 points per game, which ranks 122nd. They are allowing 42.5% from the field, placing them 135th. The Wolfpack is the 198th ranked 3-point defensive team, allowing 33.1% from behind the arc.

NC State is 6-6 against the spread this season. They are 1-3 against the spread when they have played away from home. The Wolfpack is 6-5 against the spread as a favorite and 1-3 against the spread when they have been single-digit favorites. The over is 7-5 when NC State has played this season. The over is 3-1 when they have been single-digit favorites.

Ole Miss vs NC State Picks

Ole Miss vs NC State Spread Picks

NC State Wolfpack -7 (5 units)

It’s a neutral site game in Greensboro, North Carolina, but the Wolfpack will feel the love of their home game for a key matchup. Both teams need a non-conference victory for their resume. NC State will get the win thanks to their offense. The Wolfpack are the 18th ranked offense according to KenPom and they have the 58th best scoring offense. The amount of different weapons is staggering and they will take down an Ole Miss squad that has also been poor against big time opponents. The Rebels are 2-8 against the spread this season. They are allowing at least 75 points per game, which NC State will shatter through the team’s tempo and efficiency. Ole Miss is is 1-3 against the spread when they have played away from home. The Wolfpack is 6-5 against the spread when they have been favored.

Take NC State to cover.

Ole Miss vs NC State Over/Under Pick

Over 146 (5 units)

The Wolfpack is one of the fastest teams in the nation as they rank 77th in adjusted tempo. The Rebels play at an extremely slow tempo as they rank 302nd in pace. But, the lack of defense from both sides will be key in helping the over hit. Both teams are allowing a high percentage of shots to fall and it will allow for a big score. The over is 3-1 when NC State has been single-digit favorites. For Ole Miss, the over is 6-2 when the total has been set at 149 or below.

Take the over on Sunday.Β 

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