Ole Miss vs. St. John’s Picks and Prediction, Saturday, December 6th, 2025

By: Mark Ruelle Published 12/05/2025, 11:26 PM ET
Ole Miss at St. John's CBB Prediction
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In this Ole Miss vs. St. John’s prediction, the Rebels head to the Big Apple to take on the 23rd-ranked Red Storm at Madison Square Garden on Saturday night. The Rebels are 5-3 on the season, but come in with a three-game losing streak. The Red Storm are 4-3 on the season and have dropped two of their last three games. Read on for more in this Ole Miss/St. John’s prediction and get our top Men’s College Basketball Picks to increase your bankroll!

Ole Miss Streaking in the Wrong Direction

The Ole Miss Rebels, out of the SEC, started the season hot with wins in each of their first five games. Since then, however, the Rebels have struggled against power conference teams, losing three straight games to Iowa, Utah, and, most recently, to Miami at home, 75-66. The loss to Miami was the Rebels’ first home loss of the season. They shot just 35 percent from the field and were outrebounded by the Hurricanes 45-29. Travis Perry and Patton Pinkins led Ole Miss with 11 points apiece. Malik Dia had nine points and nine rebounds, but shot just 2-of-10 from the field.

The Rebels will try to get back in the win column, but the task will be tall against the Red Storm at Madison Square Garden. They are just 1-3 against power conference teams this season. The Rebels are 130th in the nation in scoring thus far. They are 89th in scoring margin. The Rebels are 85th in offensive efficiency and just 130th in field goal shooting. They are 49th in 3-point shooting and score 48 percent of their points in the painted area, ranking them 187th in the country in that category. Defensively, the Rebels are 66th in points allowed per game. They are 98th in defensive efficiency and 89th in field goal defense. The Rebels are just 233rd in the country in 3-point defense. They are 147th in the nation in rebounding and 142nd in turnovers per game.

Key Injuries: No Injuries to Report.

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Red Storm Looks for Home Cooking

The Red Storm were primed for a run to the Final Four last year after finishing 30-4 and earning a #2 seed. They were dumped in the second round by Arkansas, however, and now head coach Rick Pitino aims for a deeper run with this year’s team. The Red Storm are 4-3 thus far, losing two of their last three games, including an 85-74 loss to Auburn at the consolation round of the Players Era Championship in Las Vegas. The Red Storm shot just 38 percent from the floor overall, including just 28 percent from 3-point range. They were led by Zuby Ejiofor’s 24 points. Joson Sanon chipped in with 16 points. The Red Storm is now 0-3 against ranked opponents this week.

The Red Storm are now just 4-3 overall and 1-3 against power conference schools. They are 9th in the country in points per game. They are 33rd in scoring margin thus far. The Red Storm are 42nd in offensive efficiency and 41st in field goal shooting. They are 125th in 3-point shooting. The Red Storm accumulates 52 percent of its points in the painted area. That ranks 100th in the nation. Defensively, the Red Storm are 207th in points allowed per game. They are 76th in defensive efficiency and 87th in field goal shooting. The team is 177th in 3-point defense. The Red Storm are 43rd in rebounding in the country and 40th in turnovers per game.

Key Injuries:  G Dylan Darling is questionable.

Ole Miss vs. St. John’s Pick 

Point Spread Pick for Ole Miss at St. John’s 

  • St. John’s -12.5 (4 units)

Both teams have struggled against power conference teams this year, going a combined 2-6. The Red Storm have the more talented roster and are particularly tough at home. They’ll take advantage of the glass, ranked 43rd in the country in rebounding. The Rebels are more of a perimeter team and aren’t particularly stout in the paint. That will leave them vulnerable to the tenacious offensive rebounding of the Red Storm. With a distinct rebounding advantage, the Red Storm will be able to get out and run. They are 26th in the country in pace of play, and they’ll jump out and run against a Rebels team that ranks just 193rd in pace of play.

Take the Red Storm -12.5

Over/Under Pick for Ole Miss at St. John’s 

  • Over 154.5 (4 units)

St. John’s has gone over this total in four of its last five games. They will get plenty of second-chance opportunities against Ole Miss, thanks to a distinct advantage on the glass. The best bet for the Rebels to stay in the game is from beyond the arc. The Rebels are 49th in the country in 3-point shooting and typically favor the perimeter over the paint. That should create more points for the Rebels.

Take the over.

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