St. John’s vs. Duke, Picks and Prediction, Friday, March 27, 2026

By: Bosun Akinpelu Published 03/27/2026, 05:25 AM ET
Red Storm vs. Blue Devils prediction
Use Code WWWC

#5 St. John’s (30-6, 18-2 Big East) will be trying to advance to the Elite Eight for the first time since the 1998-99 season when they face #1 Duke (34-2, 17-1 ACC) in the Sweet 16 round of the NCAA Tournament on Friday night. The game will be played at Capital One Arena, and it is scheduled to begin at 7:10 PM. ET. Read on to find out which team picks up the win in this Red Storm vs. Blue Devils prediction. Struggling with handicapping? Try our NCAAB Predictions!

The Red Storm are coming off a 67-65 win over Kansas as 3.5-point favorites. The Blue Devils are coming off an 81-58 win over TCU as 12-point favorites.

Duke is 8-2 in its last 10 games against St. John’s.

St. John’s Going For Ninth Consecutive Win

The Red Storm followed up their blowout win over Northern Iowa with a nail-biter against Kansas to set up their matchup with the Blue Devils. They have won eight straight games and will try to pick up their ninth win in a row when they play on Friday.

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St. John’s averages 81.1 points per game. They’ve made 45.4 percent of their field goals and 33.2 percent of their three-pointers.

Zuby Ejiofor leads St. John’s with 16.3 points and 7.3 rebounds per game. Bryce Hopkins averages 14.6 points and 6.2 rebounds per game, while Oziyah Sellers averages 10.5 points and 2.8 rebounds per game.

St. John’s is giving up 69.4 points per game. Opponents have made 42 percent of their field goals and 33 percent of their three-pointers against them.

Duke Going For 14th Consecutive Win

The Blue Devils bounced back from their near-upset at the hands of Sienna in the first round with a rout of TCU in their last game, giving them their 13th consecutive win. They are facing their toughest test of the tournament so far, and will have to be at their best if they want to move on to the next round.

Duke averages 81.9 points per game. They’ve made 49 percent of their field goals and 35 percent of their three-pointers.

Cameron Boozer leads Duke with 22.4 points and 10.3 rebounds per game. Isaiah Evans averages 15 points and 3.3 rebounds per game, while Patrick Ngongba averages 10.5 points and six rebounds per game.

Duke is giving up 63.1 points per game. Opponents have made 39 percent of their field goals and 31 percent of their three-pointers against them.

St. John’s vs. Duke Picks

Point Spread Pick for St. John’s vs. Duke

  • Duke Blue Devils -6.5 (4 Units)

The Blue Devils have the edge here because they’re playing well offensively, scoring more than 75 points per game, while making 44 percent of their shots. They’ve also done a better job at the charity stripe, making over 84 percent of their free throws in their last three games, while the Red Storm made less than 70 percent of theirs. They’re the better rebounding team, and they grabbed more than 12 offensive rebounds per game, which will give them more scoring chances. They also do a good job of protecting the ball, and won’t give up many easy-scoring chances. The Red Storm usually play well defensively, but they’re not as good on the road, and will have a hard time slowing down the Blue Devils. Take Duke to cover the spread.

Over/Under Pick for St. John’s vs. Duke

  • Under 141.5 (4 Units)

The Red Storm average 81.1 points per game. They play at the 54th-fastest pace in the nation, averaging 73.2 possessions per game, and they’re facing a team that is giving up 63.1 points per game. The Blue Devils average 81.9 points per game. They play at the 279th-fastest pace in the nation, averaging 68.6 possessions per game, and they’re facing a team that is giving up 69.4 points per game. Don’t expect these teams to score enough points to push the score over the total.

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