UConn Huskies vs. DePaul Blue Demons Picks and Prediction for Sunday, December 21, 2025
Use Code WWWC It’s a battle of Big East foes on the hardwood as the #5 UConn Huskies take on the DePaul Blue Demons Sunday afternoon in the Windy City and we have you covered with our UConn vs. DePaul prediction. UConn drubbed Butler 79-60 at home in their previous contest Tuesday, covering the line as a 15.5-point favorite. DePaul was dropped 79-66 on the road by #22 St. John’s in their previous game Tuesday night, covering the line as a 19.5-point underdog. In the all-time series between the teams, the Huskies own a commanding 21-1 advantage and have won the last 20 meetings, including a 72-61 home win in the most recent matchup January 29. Read more about this UConn vs. DePaul prediction! Struggling with handicapping? Try our NCAAB Predictions!
UConn Seeking to Vanquish Blue Demons for 21st Straight Time
UConn ran their win streak to seven games as they took down Butler at home in their previous contest Tuesday night. The Huskies improved to 11-1 on the year and stand 1-0 in Big East action with the victory. Against Butler, UConn found themselves down 11-4 at the first media timeout before regrouping. The Huskies reeled off a 26-6 run to take a 30-17 advantage with 5:36 remaining in the opening half and maintained their advantage from there. UConn was up 39-25 at the half and didn’t let Butler closer than 11 in the second half as they rolled to the win. The Huskies shot 50.8% from the field, including seven of 20 from three-point range, and won the rebounding battle 47-29 in the game. Solo Ball scored a career-high 26 points to lead the Huskies in the win.
The Huskies are above on the offensive end of the floor as they put up an average of 79 points per game, putting them 150th in the nation in scoring offense. Connecticut is grabbing 36.3 boards a night (202nd) while they are dishing out 18.4 assists a night, putting them 32nd in the nation. The Huskies are above average on the defensive end, ranking 6th by allowing 61.7 points a night. Alex Karaban is third on the team with 13 points, 5.3 rebounds and 2.1 assists per game this season. Solo Ball (15.4 points), Silas Demary Jr. (8.7 points, 4.5 rebounds, 5.6 assists) and Tarris Reed Jr. (14.6 points, seven rebounds) are solid secondary scorers. Jayden Ross, Malachi Smith, Jaylin Stewart, Eric Reibe, Dwayne Koroma and Alec Millender are critical pieces of the rotation for Dan Hurley and the Huskies. Connecticut is shooting 49.7% from the field as a team this season, which is 37th in Division I. The Huskies average 7.5 three-pointers a game while shooting 34.5% from three-point range, which is 150th in Division I. Connecticut has knocked down 69.4% of their attempts at the charity stripe this season, which is 256th in the nation.
Key Injury Report for UConn:
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- No Key Injuries
Blue Demons Hoping to Pick Up Home Win
DePaul had won three straight and six of their previous seven games but proved to be overmatched on the road against #22 St. John’s Tuesday night. The Blue Demons enter this game 8-4 overall and stand 0-1 in Big East play on the year. Against St. John’s, DePaul took their lone lead at 2-0 before giving up 10 of the next 12 points. The Blue Demons rallied to tie the game at 10 before giving up six straight points. DePaul never got even again, trailing by 11 at the half and by as many as 18 en route to the loss. The Blue Demons shot 39.1% from the field, including seven of 25 from three-point range, and turned the ball over 12 times in the loss. Kaleb Banks led DePaul with 19 points and 10 rebounds in the loss.
The Blue Demons are average on the offensive end of the floor as they put up 76.4 points per game on the year, putting them 211th in the nation in scoring offense. DePaul pulls down 33.8 rebounds per contest (297th) and dishes out 17 assists a night this season. The Blue Demons are above average on the defensive end, ranking 82nd by allowing 68.8 points per contest. CJ Gunn leads the team and is one of three players averaging in double figures with 14.3 points and 3.4 rebounds per game. NJ Benson (11.3 points, 6.5 rebounds) and Layden Blocker (10.9 points, 3.8 assists) are the most reliable secondary scoring options. Brandon Maclin, Theo Pierre-Justin, Kaleb Banks, RJ Smith, Ilija Milijasevic, Jeremy Lorenz, Kruz McClure and Khaman Maker are other key players for the Blue Demons for coach Chris Holtmann. DePaul shoots 45.4% from the floor as a team this season. The Blue Demons knock down 7.8 triples a night (205th) while connecting on 33.9% (179th) from beyond the arc. DePaul is below average when it comes to their free throw chances as they sink 70.5% of their opportunities on the year, leaving them 224th in the nation.
Key Injury Report for DePaul:
- Forward Theo Pierre-Justin (shoulder) is questionable.
UConn vs. DePaul Pick
UConn vs. DePaul Spread Pick
- UConn -14.5 (4 units)
UConn has been rolling since their loss to Arizona before Thanksgiving, winning seven straight contests. That includes triumphs over Illinois, Kansas, Florida and Texas, all of whom are in the top 45 of the KenPom rankings. As for DePaul, they have a winning record but they have beaten up on some weak fodder. The Blue Demons own five wins over teams ranked in the bottom 25 of the KenPom rankings while a sixth came over a Detroit Mercy squad ranked 295th on the year. The Blue Demons dropped their three toughest games, falling by two at home against Northwestern, by 13 at St. John’s and getting walloped by 33 on a neutral floor by LSU. It’s safe to say that UConn is the toughest team the Blue Demons have faced and they don’t match up here. Take the Huskies in this contest.
UConn vs. DePaul Over/Under Pick
- Under 136.5 (4 units)
UConn has seen the under post an 8-3-1 mark in their 12 games in relation to the total this season. The Huskies are 5th in defensive efficiency, 3rd in effective field goal percentage defense (41.9%), 87th in forced turnover percentage (19.4%) and 12th in field goal percentage defense (37.2%) this season. UConn is 316th in tempo with 66.3 possessions a night. On the season, the Blue Demons have seen the under post a 7-4-1 mark in their 12 games. That includes an under in their lone road contest of the season. DePaul is 77th in defensive efficiency, 70th in effective field goal percentage defense (47.7%) and 57th in forced turnover percentage (20.1%) on the year. The Blue Demons are 201st in adjusted tempo with 68.6 possessions per game. Look for UConn to take the air out of the ball and the DePaul offense, keeping this under the number.
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