Arizona State vs. Colorado Odds, Preview, Picks, and Prediction for Saturday, November 22, 2025
On Saturday, the Colorado Buffaloes will host the Arizona State Sun Devils in a Week 13 NCAAF game at Folsom Stadium. The Big 12 Conference matchup is scheduled for 8:00 p.m. ET.
The Sun Devils are seven-point spread favorites, and the total is 46.5 points scored.
This Arizona State vs. Colorado prediction highlights a Sun Devils team that is 5-2 in Big 12 competition (fifth place) and 2-2 on the road, and a Buffaloes squad that's 1-6 in conference play (15th place) and 3-3 at home this year. Saturday's game marks the 14th meeting between ASU and CU on the gridiron. The Sun Devils lead the series 9-4, but the Buffs won the most recent matchup (2023).
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Can the Sun Devils finish strong?
Arizona State (7-3 SU, 5-5 ATS, and 3-7 O/U) has won three of its last four games, earning close victories over Texas Tech, Iowa State, and West Virginia.
In last Saturday's home win over the Mountaineers, ASU took control in the second quarter with 22 points and held off the visitors with a late field goal in the fourth. With star QB Sam Leavitt out for the second straight game, journeyman backup Jeff Sims led the charge with 288 yards and three touchdowns. Sparky was outgained 421-330, but the defense forced an interception and held WVU to 68 rushing yards on 39 carries (1.7 YPC). The Mountaineers were also 1-for-4 on fourth down.
“Right now, we're getting it done,” Sun Devils coach Kenny Dillingham said. “It's so cool watching these guys through all the adversity, it's like, 7-3, we're still in this thing.”
With Leavitt out for the season due to a foot injury, Sims will be ASU's QB1 against Colorado. He has completed 55.4 percent of his passes for 566 yards with five touchdowns and one interception, averaging 5.6 yards per pass. While inefficient through the air, Sims brings value to the run game (75 carries for 411 yards and two rushing TDs). Sims' top receiving targets are junior WR Jordyn Tyson (57 receptions for 628 yards and eight TDs) and senior TE Chamon Metayer (35 receptions for 370 yards and four TDs). Junior RB Raleek Brown leads Arizona State's ground game with 151 carries for 823 yards (5.4 YPC) and three touchdowns.
ASU scores 24.7 points per game (87th) and averages 401.2 total yards (59th), including 219.4 passing yards (78th) and 181.8 rushing yards (39th). The Sun Devils' defense allows 23.6 points (62nd) and 343.4 total yards (46th) per game, including 225.7 passing yards (80th) and 117.7 rushing yards (28th).
Arizona State Sun Devils Football Injury Report:
- Leading WR Jordyn Tyson is questionable after missing the last three weeks with a hamstring injury. He practiced earlier this week, but it's currently unclear if he will be available to play against Colorado.
Colorado hopes frosh QB Lewis will provide a spark
Colorado (3-7 SU, 3-6-1 ATS, and 4-5-1 O/U) has lost three straight Big 12 contests and has failed to cover the spread as underdogs in four of its last five games. The Buffaloes are coming off a bye week.
In its Week 11 road loss to West Virginia, CU trailed early and battled within three points twice, but was unable to complete the comeback. The Buffs' defense forced three turnovers, and freshman QB Julian Lewis passed for 299 yards, giving Colorado hope late in the game. The highly-recruited 18-year-old had appeared in two games as a backup, but got his first starting nod against WVU, posting a 153.5 passer rating. Unfortunately for Lewis, he didn't have a complementary run game to lean on, as the Buffaloes couldn't get into gear on the ground (38 carries for 51 yards).
"It felt amazing playing football again,” Lewis said. “But of course, it hurts to lose. We have to play better.”
"JuJu" is expected to remain Colorado's QB1 the rest of the season, taking over for senior Kaidon Salter, who completed 63.1 percent of his passes for 1,242 yards with ten touchdowns and six picks. The Buffaloes' top receiving targets are junior WR Omarion Miller (34 receptions for 652 yards and seven TDs) and sophomore WR Joseph Williams (30 receptions for 450 yards and four TDs). The CU run game is paced by sophomore RB Micah Welch (81 carries for 313 yards and two scores).
The Buffaloes score 22.0 points per game (108th) and average 331.8 total yards (114th), including 209.7 passing yards (91st) and 122.1 rushing yards (108th). The Colorado defense surrenders 30.0 points (107th) and 420.7 total yards (119th) per game, including 209.8 passing yards (54th) and 210.9 rushing yards (133rd).
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Colorado Buffaloes Football Injury Report:
- Starting offensive linemen Jordan Seaton and Larry Johnson II are questionable. Neither played in Colorado's last game two weeks ago, contributing to Lewis getting sacked seven times.
- LB Jeremiah Brown (second-leading tackler) is questionable.
- Safety Carter Stoutmire (35 tackles and 5 passes defended) is questionable.
Arizona State vs. Colorado Pick and Preview
Spread Pick for Arizona State vs. Colorado
- Sun Devils -7 (4 Units)
I like Arizona State's odds of winning by more than a touchdown.
If Colorado is without one or both of its injured starting OL, Lewis will be in for a long night. The Buffaloes have struggled in pass protection, allowing 31 sacks (122nd), and they rank 135th (out of 136 teams) in Havoc allowed. There's only so much a freshman QB can do with that kind of pressure. The Sun Devils can really bring it, too, ranking 18th in sacks and 14th in Havoc generated this season. The Buffaloes also lack a reliable complementary run game (130th in rushing success rate), contributing to an overall inefficient offensive attack (122nd in quality drive rate).
Arizona State should be able to put up enough points on the scoreboard to win comfortably. The 23-year-old Sims has been around the block a few times and has fared well in Leavitt's place. He has boosted an ASU run game that ranks top-20 in EPA/rush, and won't be slowed down by CU (110th in defensive success rate against the run).
Over/Under Pick for Arizona State vs. Colorado
- Under 46.5 (5 Units)
I preferred this play at 49, but it's still my recommendation at 46.5. The Sun Devils will be content pounding away against the Buffaloes' weak run defense, controlling the game clock. That's been an effective game plan for them this season, as they rank 9th nationally in average time of possession. That isn't likely to change against Colorado, which ranks 100th in average TOP. On the other side of the ball, the home team will struggle to sustain drives (80th in third-down conversion percentage), especially with a banged-up offensive line.
The under is 7-3 in ASU's games this season, including 5-2 in its Big 12 games. That's a trend I'll back against a Buffs team that's onto its third starting QB and has scored just 46 combined points in its previous three games (15.3 PPG).
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