Arizona vs. Colorado, Odds, Preview, Picks and Prediction, Saturday, November 1st, 2025
Use Code WWWC In this Arizona at Colorado prediction, the Wildcats hit the road to take on the Buffaloes in Colorado at Folsom Field on Saturday night. Arizona comes in with a 4-3 record, including just 1-3 in conference play. The Buffaloes are 3-5 on the season and just 1-3 in the Big 12. The opening kick is scheduled for 7:30 pm EST. Don’t get sacked this football season! Try our College Football Picks!
Arizona Chases Fifth Win of the Season
The Arizona Wildcats return to action this week after a heartbreaking loss to Houston on the road two weeks ago. The Wildcats now return from their bye week with an overall record of 4-3, riding a two-game losing streak. They have also lost three of their last four games.
“Obviously, coming off a really hard day Saturday in Houston. I thought coach Fritz and that staff did a great job, but obviously, a very disappointing ending for us. Now we're into this bye week, and it's a really important time for us, an opportunity for us to get fresh and for us to dive into the fundamental parts of playing football.” Head coach Brent Brennan said after the heartbreaking loss two weeks ago.
Arizona quarterback Noah Fifita finished an efficient 24-of-26 for 269 yards and two touchdowns against the Cougars. Trailing 28-14 entering the fourth quarter, he led the Cougars on two touchdown drives, knotting the game at 28 before Houston closed the game out with a winning field goal. Fifita threw touchdown passes to Trey Spivey for 70 yards and to Luke Wysong for 13 yards. Spivey also added a 3-yard touchdown as part of the fourth-quarter comeback. In all, the Wildcats finished with 381 yards of total offense.
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Defensively, the Wildcats allowed 391 yards of total offense to the Cougars. They were particularly gouged on the ground, allowing 232 yards of rushing. The Wildcats’ defense struggled to get off the field, allowing Houston to convert on 10-of-16 conversions. The Wildcats finished with three players in double-digit tackles. Max Harris led the way with 13 tackles. Dalton Johnson finished with 11, and Taye Brown added 10 tackles in a losing effort.
Arizona comes into this contest ranked 54th in the country in points per game. The Wildcats are 66th in rushing and 41st in passing. They are 84th in red zone offense and are just 103rd in sacks allowed per game this season. On the defensive end, Arizona ranks 47th in scoring defense. The Wildcats are 39th against the run and an impressive 11th against the pass. They are just 110th in red zone defense. The Wildcats are 57th in sacks per game. They are 40th in penalty yards per game and 34th in turnover margin.
Key Injuries: TE Kellen Ford is out. WR Rex Hayes, WR Landon Kelsey, WR Jeremiah Patterson, and TE Chase Randle are all questionable.
Colorado Needs Wins to Earn Bowl Bid
The Colorado Buffaloes hit rock bottom last Saturday night in a 53-7 loss to Utah on the road. It was the team’s third loss in four games and came off an impressive win over Iowa State just two weeks ago. The Buffaloes fell to 3-5 on the season with the loss.
"This was bad," Head coach Deion Sanders said. "It's probably the worst beating I've ever had. Four hundred twenty-two yards rushing. You ain't winning. Three hundred yards, you're not winning. Two hundred fifty, you're not winning. It's not capable. Total offense, 140 yards, you're not winning. Five hundred eighty-seven yards of total offense, you're not winning. Special teams gave up a fake punt as well as a blocked punt; you're not winning. So, all three phases, we got our butts kicked."
The Buffaloes never stood a chance in this one. They trailed 43-0 at the half and scored their lone touchdown in the fourth quarter with the game well out of reach. Offense was hard to come by for Colorado last Saturday night. The team finished with just 140 total yards in the game. Quarterback Kaidon Salter finished with just 37 yards passing. His backup, Ryan Staub, came in and threw for 65 yards in the loss. Colorado rushed for just 38 yards in the contest.
The defense failed miserably as well against the Utah attack. Colorado allowed 587 yards of total offense against the Utes, including a startling 422 yards on the ground. They gave up 25 first downs in the game. Tawfiq Byard finished with 10 tackles to lead the Buffaloes. Jeremiah Brown had Colorado’s only sack of the game, finishing with two tackles for loss and nine total tackles in the game.
The Buffaloes are three wins away from earning an automatic bowl bid for the second straight season. They come into this contest ranked 94th in points per game this season. The Buffaloes are 90th in rushing and 95th in passing. They are 54th in red zone offense. The Buffs are 113th in sacks allowed per game. On the defensive end, Colorado ranks 79th in scoring defense. The Buffaloes are just 126th against the run, but a more efficient 43rd against the pass. They are 69th in red zone defense. The Buffaloes are 120th in sacks per game. They are 30th in penalty yards per game. They are 81st in turnover margin in the country.
Key Injuries: WR Jack Hestera and TE Sav’ell Smalls are questionable. RB Simeon Price, RB DeKalon Taylor, and TE Clarke Williams are out.
Arizona at Colorado Pick
Point Spread pick for Arizona at ColoradoÂ
- Arizona -4.5 (4 units)
Colorado’s offense has struggled all season. The Buffaloes are now up against a talented defense in Arizona. The Wildcats are 47th in the nation in scoring defense and have shut down opposing passing attacks, ranking 11th against the pass. They are also a solid 39th against the run. The Buffaloes are not particularly tough on offense this season after several departures on that side of the ball in the offseason. The Buffs are just 90th in rushing the ball and 95th through the air. Don’t expect a big offensive night. Defensively, the Buffs haven’t been much better and have to do soul-searching after being demolished by the Utes last week. Arizona has a chance to ground and pound against the nation’s 126th-ranked rush defense. That will set up the pass later in the game. Arizona will move closer to a bowl bid with a big win on Saturday in Boulder.
Take the Wildcats -4.5
Over/Under Pick for Arizona vs. ColoradoÂ
- Over 53.5 (4 units)
The Buffaloes, while a below-average offensive team, have gone over this number in three of their last five games. They have allowed over 37 points per game in their last three losses. The Wildcats have allowed just under 30 points per game in their last four games. They have scored 32 points per game in their last two wins. This one will sail past the number.
Take the over.
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