Buffalo Bulls vs. Central Michigan Chippewas Picks and Prediction for Wednesday, November 12, 2025

By: Chris King Published 11/10/2025, 11:03 PM ET
Buffalo vs. Central Michigan Prediction
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A pair of MAC programs collide on the gridiron in the Great Lakes State as the Buffalo Bulls travel to take on the Central Michigan Chippewas Wednesday night and we have you covered with our Buffalo vs. Central Michigan prediction. Buffalo rolled to a 28-3 win over Bowling Green on the road last Saturday in their previous contest, winning outright as a three-point underdog. Central Michigan fell 24-21 to Western Michigan last Saturday on the road in their previous game, covering the line as a six-point underdog. In the all-time series between the schools, the Chippewas own an 8-4 advantage, though Buffalo picked up a 37-13 home win in the most recent matchup on October 7, 2023. Read more about this Buffalo vs. Central Michigan prediction! Don’t get penalized! Increase your bankroll with our NCAAF Betting Picks!

Buffalo Battling for Potential Spot in MAC Title Game

Buffalo won for the third time in four games as they took down Bowling Green on the road in their previous contest last Saturday. The Bulls improved to 5-4 overall and are part of a four-way tie for the top spot in the MAC with a 4-1 record. Against Bowling Green, Buffalo took the lead just 63 seconds into the game and led the rest of the way. The Bulls were up 7-0 after the opening quarter, 21-0 at the half and 28-0 after three quarters en route to the victory. Buffalo rolled up a 282-216 edge in total offense, forced two turnovers while committing one and scored on a punt return in the game. Those numbers offset the fact that they allowed 15 first downs while recording 10 and lost time of possession by a 34:00 to 26:00 margin in the contest.

The Bulls are struggling offensively this season as they try to find the right pieces to plug into the system. Buffalo is 89th in the nation in passing offense with 212.6 yards per game: the team is 81st in rushing offense with 145.1 yards per contest. To this point of the year, Buffalo is 88th of the 136 teams in the FBS to play a game this season in scoring offense with an average of 24.8 points per contest, while they are 23rd in scoring defense by allowing 19.6 points per game. Ta’Quan Roberson is the triggerman for the Buffalo offense though he has been inconsistent, completing 150 of 248 passes for 1,739 yards with 12 touchdowns and eight interceptions. He is third on the team with 149 rushing yards and two scores. Gunnar Gray (23 of 44, 174 yards, TD, INT) is the backup quarterback. Al-Jay Henderson (161 carries, 663 yards, five TD) and Lamar Sperling (34 carries, 202 yards, TD) provide a 1-2 punch in the ground game. Terrance Shelton Jr. (23 carries, 101 yards, TD) is next in line. In the passing game, Victor Snow leads the team with 45 catches for 586 yards and seven scores on the year. Nik McMillan (42 receptions, 590 yards, TD), Jasaiah Gathings (25 grabs, 274 yards, TD) and Henderson (25 grabs, 181 yards, TD) are the only other players with at least 150 receiving yards. Jack Howes is 25 of 25 on extra point attempts and 10 of 13 on field goal attempts with a long of 50 this year.

Chippewas Seeking to Get Back in Win Column

Central Michigan saw their two-game winning streak snapped as they were downed by Western Michigan in their previous contest. The Chippewas fell to 5-4 overall on the season and stand tied for fifth in the MAC with a 3-2 conference mark. Against Western Michigan, Central Michigan led 7-0 after one quarter, 14-7 at the half, was even at 14 after three quarters and took a 21-14 lead in the opening seconds of the fourth quarter. The Chippewas couldn’t hold the lead, giving up the game’s final 10 points, to wind up with the loss. Central Michigan was outgained 327-240 in total offense, allowed 23 first downs while picking up 13, lost time of possession by a 33:42 to 26:18 margin and turned the ball over twice while forcing just one takeaway.

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On the season, the Chippewas are tied for 125th in the nation in passing offense by averaging 153.6 yards per contest, while they are 35th in rushing offense with an average of 185.3 yards per game this season. Central Michigan is 92nd in the FBS in scoring offense as they put up 24.1 points per game, while they are 65th in scoring defense by allowing 24 points per contest. Joe Labas has completed 78 of 109 passes for 1,066 yards with eight touchdowns against two interceptions while adding 18 rushing yards. Angel Flores (19 of 27, 195 yards, two TD, 519 rush yards, eight TD), Jadyn Glasser (seven of nine, 78 yards, seven rush yards, TD), Marcus Beamon (one of one, 33 yards, TD, 19 rush yards) and Ethan Lane (one of three, 10 yards) have all seen action. In the ground game, Nahree Biggins is the lead back with 81 carries for 426 yards and two scores. Trey Cornist (69 carries, 299 yards, TD) and Brock Townsend (53 carries, 288 yards, two TD) have also taken part in the workload this season. Langston Lewis leads the team with 21 catches for 295 yards and two scores this season. Tommy McIntosh (14 receptions, 225 yards, TD), Tyson Davis (14 grabs, 181 yards, two TD), Biggins (15 grabs, 158 yards, TD) and Townsend (nine catches, 134 yards, three TD) are other top options when the Chippewas go to the air. Cade Graham is 25 of 25 on extra point attempts and 12 of 14 on field goal attempts this season with a long of 47.

Buffalo vs. Central Michigan Pick

Moneyline Pick for Buffalo vs. Central Michigan

  • Buffalo +110 (4 units)

Give Pete Lembo credit as he’s made Buffalo a tough defensive team since taking over the program last season. The Bulls have been stout against the run, allowing just 3.4 yards per carry on the year. That is going to test Central Michigan, who rely heavily on the run game as their passing attack leaves plenty to be desired. The Chippewas have been good at forcing takeaways, recording 13 in nine games, and that is something they’ll have to do to have success. Central Michigan is 3-0 at home and Buffalo is 3-1 on the road, with their lone loss coming to a Big Ten team in Minnesota. With the Bulls being better defensively, they keep Central Michigan in check and come up with a road win here.

Over/Under Pick for Buffalo vs. Central Michigan

  • Under 44 (4 units)

Buffalo enters this game having seen the under post a 5-4 mark in their nine games this season. The Bulls have split their four road games this season in relation to the total. Central Michigan has gone over the number in six of their nine games on the year. The Chippewas went over the mark in two of their three home games, though one of those was over Wagner, an FCS program. With both teams being subpar offensively and at least slightly above average on the defensive side of things, we shouldn’t expect a ton of offensive fireworks from these teams here. Lean toward the under as 21 to 24 points should be enough to prevail here.

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