Cincinnati vs. Oklahoma State Picks and Prediction, Saturday, October 18th, 2025

By: Mark Ruelle Published 10/16/2025, 06:38 PM ET
Cincinnati at Oklahoma State CFB Prediction
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In this Cincinnati at Oklahoma State prediction, the red-hot Bearcats travel to Oklahoma to take on the struggling Cowboys. The Bearcats are now 5-1 after upending Kansas last week. The Cowboys are just 1-5 on what has been a tumultuous season after firing their longtime head coach, Mike Gundy. The opening kick is scheduled for 8:00 pm EST. Don’t get sacked this football season! Try our College Football Picks!

Cincinnati perfect in Big 12

The Cincinnati Bearcats have now vaulted into the top 25 after five straight wins, including a 20-11 win over South Florida last Saturday. The Bearcats are now 5-1 on the season and an impressive 4-0 to start conference play in the Big 12.

“So just really proud of the way those guys continue to play at a high level. The bottom line is, we're sitting here at 5-1 and we just finished this game and won our third conference game in a row … and we've got things we can get fixed. That's a good thing to have and we're excited about this opportunity we have coming next week." Head coach Scott Satterfield said after the win.

Quarterback Bremdam Sorsby continued his hot start, throwing a pair of touchdowns to wideout Jeff Caldwell in the first half to lead the Bearcats to a win. He finished with 191 yards passing and didn’t commit a turnover, the fifth straight clean game for the young quarterback. Caldwell caught three balls in total for 58 yards. The Bearcats finished with 306 yards of total offense at 6.4 yards per play. They were just 2-of-9 on third down conversions.

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The defense delivered despite being on the field twice as long as UCF’s defense. They allowed 413 yards of total offense, but in 90 plays, holding them to 4.2 yards per play. The Bearcats had five tackles for loss, including two sacks. Safety Tre Gola-Callard finished with a team-leading nine tackles, while fellow safety Christian Harrison was solid downfield, with three pass breakups in the game.

Cincinnati is ranked 51st in the country in points per game. The Bearcats are 10th in rushing and 57th in passing. The team is first in the nation in red zone offense. They are also tops in the country in fewest sacks allowed. On the defensive side of the ball, the Bearcats are 47th in scoring defense. They are 50th against the run and just 111th against the pass. The Bearcats are 63rd in red zone defense. They can get after the quarterback, ranked 21st in sacks per game. The Bearcats are 90th in turnover margin and 120th in the country in penalty yards per game.

Key Injuries: No Injuries to Report.

Lost season for the Cowboys

It has been a dreadful season for the Oklahoma State Cowboys in 2025. The team parted ways with head coach Mike Gundy after over 20 seasons at the helm. The defensive coordinator was dismissed one week later, and the team is completely off the rails. That continued last week in a 39-17 loss at home to the Houston Cougars. The Cowboys are now just 1-5 and sinking fast.

“We had a collection of things occur… A bad snap, a penalty, offsides, pass interference, and it just kind of spiraled… It's frustrating because I know how much it means to these guys in the locker room, it's not like they're giving up, there are some upset guys in there." Interim head coach Doug Beacham said.

The Oklahoma State Cowboys have had a miserable season, and things didn’t get any easier in their loss to Houston at home last week. The team had to turn to converted wide receiver Sam Jackson V at quarterback with injuries to both Zane Flores and Hauss Hejny. Jackson went 7-of-16 for 84 yards and a pick in his first career start. Noah Walters took over on the final drive, leading the Cowboys to a score. In all, they finished with just 228 yards of total offense, including just 45 yards on the ground.

The Oklahoma State defense didn’t fare much better. They allowed 485 yards of total offense, including 316 through the air. The defense gave up 27 first downs, more than double the Cowboys’ output. Mordecai McDaniel was all over the field for the Cowboys, leading the team with 13 tackles.

Oklahoma State is ranked 127th in the nation in points per game. The Cowboys are 98th in rushing and 123rd in passing. The team is 54th in red zone offense and 67th in sacks allowed. On the defensive side of the ball, the Cowboys are 134th in scoring defense. They are 103rd against the run and 135th against the pass. Oklahoma State is 106th in red zone defense in the nation. They are 83rd in sacks per game. The team is 62nd in turnover margin and 95th in fewest penalty yards per game.

Key Injuries: RB Freddie Brock IV, QB Zane Flores, TE Josh Ford, TE Oscar Hammond, WR Da’Wain Lofton, TE Will Monney, and TE Quinton Stewart are questionable.

Cincinnati at Oklahoma State 

Point Spread pick for Cincinnati at Oklahoma State 

  • Cincinnati -22.5 (4 units)

The Bearcats come into this game red-hot, with five straight wins after dropping a 3-point decision to Nebraska to open the season. They face an Oklahoma State team that has lost its four games to power five conference teams by an average of over 33 points. The Bearcats will have their way in the red zone, ranked first in the country in red zone offense. They’ll also be facing the nation’s 134th-ranked scoring defense. Oklahoma State ranks just 106th in red zone defense. They are also just 103rd against the run, a bad sign against a Bearcats team that is ranked 10th in the nation in rushing. The Cowboys are a mess with coaching changes and off-the-field drama. Don’t expect much of a fight in this one. Uncertainty at quarterback will also be an issue for the Cowboys. The Bearcats will roll to victory.

Take the Bearcats -22.5

Over/Under Pick for Cincinnati at Oklahoma State 

  • Over 58.5 (4 units)

The Bearcats had their first under-30-point game last week since week one in the win over South Florida. They will get back on track against an Oklahoma State team that ranks just 134th in the country in scoring defense. The defense has gone through major changes since the firing of the team’s head coach and defensive coordinator. It hasn’t stopped the bleeding, still giving up 40 points per game in the last two weeks. This one will be another one-sided affair, and scoring will come fast and easy for the Bearcats.

Take the over.

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