Coastal Carolina vs Old Dominion Prediction and Picks - October 4th, 2025
Use Code WWWC Saturday evening on the College gridiron, and we have a Coastal Carolina vs Old Dominion Prediction loaded up and ready to roll. The Chanticleers come in off a strong 38-20 road win over South Alabama, which puts them at 2-2 on the year. Old Dominion improved to 3-1 on the year with a solid 21-7 win over Liberty. Coastal Carolina won last year's meeting by a score of 45-37. Can ODU get revenge for that loss? Continue reading to see our Coastal Carolina vs Old Dominion prediction.
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Chanticleers Tame The Jaguars
Coastal Carolina enters Week 6 at 2–2 after rallying for a 38–20 road win over South Alabama in their Sun Belt opener. The Chanticleers trailed 14–7 at halftime but flipped the game with a dominant second half, scoring 24 unanswered points before a late defensive touchdown sealed it. Quarterback Tad Hudson threw two second-half touchdowns and finished 13-of-25 for 112 yards with no interceptions. Running back Ja’Vin Simpkins led the ground game with 84 yards and a touchdown on nine carries, while Tray Brown returned a fumble for a score to cap off the win.
Despite entering the game ranked last in the FBS in scoring (6.7 PPG), Coastal found rhythm offensively behind a run-heavy approach and opportunistic defense. Hudson’s stat line was modest, but he avoided mistakes and added a rushing touchdown. Simpkins and backup backs Jamey Edwards and Damarcus Knicely combined for 167 rushing yards, helping Coastal control tempo and wear down South Alabama’s front. The Chanticleers were outgained 420–294 in total yardage but won the turnover battle 3–0 and capitalized on short fields created by special teams miscues and defensive takeaways.
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Heading into their matchup with Old Dominion, Coastal will need to replicate that formula: protect Hudson, lean on Simpkins’ burst, and force mistakes defensively. The passing game remains limited, with Bryson Graves leading all receivers with just 35 yards last week, but the Chanticleers have shown they can win with field position and ball control. Defensively, they’ll be tested by Colton Joseph’s mobility and ODU’s balanced attack, but if they can pressure the quarterback and stay disciplined in coverage, Coastal has the tools to stay competitive in Norfolk.
Defense Stands Tall Against Liberty
Old Dominion enters this matchup at 3–1 after a dominant 21–7 win over Liberty. Quarterback Colton Joseph was outstanding, throwing for 271 yards and three touchdowns on 18-of-26 passing, while also rushing for 76 yards on 15 carries. Running back Trequan Jones added 89 yards on 16 carries, and wide receiver Ja’Cory Thomas had a breakout performance with five catches for 114 yards and two scores. The Monarchs controlled the game from start to finish, holding Liberty to just 237 total yards and forcing two turnovers.
Joseph has emerged as one of the most dynamic dual-threat quarterbacks in the Sun Belt, averaging 91.8 rushing yards per game—second among FBS quarterbacks—and ranking fifth nationally in yards per carry (8.16). He’s thrown for 900 yards and eight touchdowns through four games, while Jones has averaged 117.7 rushing yards per contest. Thomas leads the receiving corps with 307 yards and three touchdowns, and the defense has been stout, allowing just 18.5 points per game. ODU is 3–1 against the spread and has covered in both home games this season.
Facing Coastal Carolina, Old Dominion will look to pressure Vasko and force him into quick decisions. Joseph’s mobility will be a major factor, especially if Coastal struggles to contain the edge. Expect ODU to lean on Jones early to set up play-action shots to Thomas and Tre’ Brown III. Defensively, the Monarchs will aim to disrupt Coastal’s timing and win the battle up front. With momentum and home-field advantage, ODU is positioned to make a statement in Sun Belt play—but they’ll need to stay sharp against a Coastal team capable of striking quickly.
Coastal Carolina vs Old Dominion Pick
Coastal Carolina vs Old Dominion Spread Pick
- Old Dominion -20.5 (4 Units)
Old Dominion laying 20.5 is justified given the trajectory of both programs and the matchup dynamics. The Monarchs are 3–1 and coming off a dominant 21–7 win over Liberty where Colton Joseph threw for 271 yards and three touchdowns while rushing for 76 more. Their defense held Liberty to just 237 total yards and forced two turnovers, continuing a trend of physical, assignment-sound play. Coastal, meanwhile, is just 2–2 and coming off a misleading 38–20 win over South Alabama where they were outgained by 126 yards and relied on short fields and a defensive score. Tad Hudson threw for just 112 yards, and the Chanticleers remain one-dimensional offensively.
ODU’s front seven should control the line of scrimmage against a Coastal team that leans heavily on Ja’Vin Simpkins and the run game. Joseph’s dual-threat ability will stress a Chanticleer defense that’s allowed 27.3 points per game and struggled to contain mobile quarterbacks. With Ja’Cory Thomas emerging as a legit deep threat and Trequan Jones pounding between the tackles, ODU has the balance and explosiveness to pull away. Add in home-field advantage and Coastal’s 1–3 ATS record, and the Monarchs are well-positioned to cover a big number against a team still searching for offensive identity.
Coastal Carolina vs Old Dominion Over/Under Pick
- Over 54.5 (5 Units)
Over 54.5 is in play with Old Dominion’s offense clicking and Coastal’s defense vulnerable to dual-threat quarterbacks. Colton Joseph has accounted for over 1,200 total yards through four games and just torched Liberty for 347 combined yards and three scores. Coastal gave up 420 yards to South Alabama despite winning, and their secondary has struggled against mobile QBs and play-action. With Ja’Cory Thomas stretching the field and Coastal’s run game capable of breaking chunk plays, this matchup sets up for explosive drives, short fields, and a pace that favors points on both sides.
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