Colorado Buffaloes vs Kansas State Wildcats Prediction and Picks - November 29, 2025
Big 12 Saturday afternoon, College football action, and we have a Colorado vs Kansas State prediction locked and loaded for you. The Buffaloes enter this game off a 42-17 home loss to Arizona State to fall to 3-8 on the year. Kansas state is now 5-6 on the year after a tough 51-47 loss at Utah last week. Kansas State won last year's meeting on the road by a score of 31-28. Can Colorado get revenge for that loss. Can the Wildcats gain bowl eligibility? Read on to see our Colorado vs Kansas State prediction.
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The Long Season Is Almost Over
Colorado enters the season finale at 3-8 overall and 1-7 in Big 12 play, coming off a 42-17 home loss to Arizona State on November 22. Freshman quarterback Julian Lewis threw for 161 yards and a touchdown in his second career start, connecting with Omarion Miller on a 22-yard score in the third quarter. Running back Dallan Hayden added a short rushing touchdown in the first quarter, but turnovers and defensive breakdowns doomed the Buffaloes as the Sun Devils piled up 580 yards of offense. Colorado was competitive early, trailing just 13-7 at halftime, but a disastrous fourth quarter sealed their fate.
Offensively, the Buffaloes have averaged 328.9 yards per game and 21.5 points per contest, ranking near the bottom of the Big 12. Lewis has shown flashes of promise, throwing for nearly 600 yards and four touchdowns across limited action, while Kaidon Salter has contributed over 1,200 passing yards and 10 scores. Omarion Miller has been the standout receiver with 687 yards and eight touchdowns, while Joseph Williams adds balance with 489 yards and four scores. Dean Connors and Micah Welch have combined for over 1,100 rushing yards, but the ground game has lacked consistency. Colorado’s offense has leaned heavily on big plays through the air, but sustaining drives has been a season-long issue.
Defensively, Colorado has struggled, allowing 31.1 points per game and more than 435 yards per outing. Opponents have gashed them on the ground, averaging 224 rushing yards per game, while the secondary has surrendered 211 passing yards per contest. The Buffaloes have forced just 17 turnovers all season, and their inability to stop explosive plays has been costly. Heading into the finale against Kansas State, Colorado will need its young quarterbacks to protect the ball and the defense to find a way to slow down a Wildcats offense that has been efficient all year.
Kansas State Loses A Wild One To Utah
Kansas State sits at 5-6 overall and 4-4 in Big 12 play, still fighting for bowl eligibility after a wild 51-47 road loss to Utah on November 22. The Wildcats rushed for a program-record 472 yards, with Joe Jackson exploding for 293 yards and three touchdowns, but Utah rallied late behind quarterback Devon Dampier’s heroics. Avery Johnson threw for 102 yards and a touchdown while adding 72 yards on the ground and a score. Despite the offensive fireworks, Kansas State’s defense couldn’t hold up in the fourth quarter, allowing 16 points in the final frame as Utah stole the win.
Offensively, the Wildcats have been strong all season, averaging 374.5 yards per game and nearly 30 points per contest. Johnson has thrown for 2,270 yards and 18 touchdowns, while also rushing for 441 yards and eight scores, making him one of the most versatile quarterbacks in the Big 12. Jackson has been the workhorse in the backfield with 769 rushing yards and five touchdowns, while Jayce Brown leads the receiving corps with 712 yards and five scores. Tight end Garrett Oakley adds another dimension with 389 yards and six touchdowns, giving Johnson multiple reliable targets. Kansas State’s ability to mix explosive runs with efficient passing has kept them competitive in nearly every game.
Defensively, Kansas State has been inconsistent, allowing 27.8 points per game and nearly 392 yards per outing. Their run defense has been shaky at times, giving up 165 rushing yards per game, while the secondary has surrendered 227 passing yards per contest. The Wildcats have forced 25 turnovers, one of the best marks in the country, which has helped them stay afloat in close games. Against Colorado, Kansas State will look to lean on its rushing attack to control tempo while hoping the defense can limit Miller and Williams in the passing game. With bowl eligibility on the line, the Wildcats have plenty of motivation to finish strong at home.
Colorado vs Kansas State Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vinciletti | +1,570.00 |
| 2 |  Dan Kaiser | +1,223.00 |
| 3 |  Ross Benjamin | +1,000.00 |
| 4 |  Earle Sports Bets | +916.00 |
| 5 |  David Hess | +706.00 |
Colorado vs Kansas State Spread Pick
- Kansas State -17 (4 Units)
Kansas State laying -17.5 feels justified given the way their offense has been rolling and Colorado’s inability to keep pace. The Wildcats are averaging nearly 30 points per game and over 374 yards of offense, with quarterback Avery Johnson providing balance as both a passer (2,270 yards, 18 TDs) and runner (441 yards, 8 TDs). Running back Joe Jackson has been a force with 769 rushing yards, and Jayce Brown leads the receiving corps with 712 yards and five scores. Against a Colorado defense that’s giving up 31.1 points per game and more than 435 yards per outing, Kansas State’s ability to control tempo and hit explosive plays should create separation quickly.
Colorado, meanwhile, has struggled to generate consistent offense, averaging just 21.5 points per game and under 330 yards of total offense. Their quarterbacks have combined for 2,200 passing yards but with uneven efficiency, and while Omarion Miller has been a bright spot with 687 yards and eight touchdowns, the Buffaloes’ ground game has lacked punch. Defensively, they’ve been gashed for 224 rushing yards per game, which is a nightmare matchup against Kansas State’s run-heavy attack. With the Wildcats fighting for bowl eligibility and Colorado’s defense unable to slow down physical rushing teams, the gap in talent and execution makes Kansas State -17.5 the right side.
Colorado vs Kansas State Over/Under Pick
- Over 50.5 (5 Units)
The Over 50.5 looks like a strong angle because Kansas State’s offense has been consistently productive, averaging nearly 30 points per game with Avery Johnson’s dual‑threat ability and Joe Jackson’s explosive rushing presence. Colorado, despite its struggles, still has playmakers like Omarion Miller and Joseph Williams who can stretch the field and generate chunk plays, and the Buffaloes’ defense has been porous, giving up more than 31 points per outing and over 435 yards per game. With Kansas State pushing tempo on the ground and Colorado capable of hitting a few big strikes through the air, this matchup sets up for enough scoring on both sides to push past the 50.5 total.
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