Colorado Buffaloes vs West Virginia Mountaineeers Prediction and Picks - November 8, 2025
Use Code WWWC Big 12 CFB action on Saturday afternoon, and we have a Colorado vs West Virginia prediction locked and loaded for you. The Buffaloes are reeling as they are just 3-6 on the year and have lost their last two games by a combined 105-24. West Virginia is also 3-6 on the year, but they do come in off a 45-35 road win over Houston. These teams last met in 2009, and West Virginia won that game at home by a score 35-24. Read on to see our Colorado vs West Virginia prediction.
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The Long Season For The Buffaloes Continues
Colorado comes into Morgantown reeling after back-to-back blowout losses, the latest a 52-17 drubbing at home against Arizona. The Buffaloes were out of it early, trailing 38-7 at halftime, and the frustration was evident with penalties and turnovers piling up. Head coach Deion Sanders took the blame postgame, shielding his players from the media, but the reality is this team has been outscored 105-24 over its last two contests. The one bright spot was true freshman quarterback Julian “JuJu” Lewis, who came off the bench and delivered a 59-yard touchdown strike to Omarion Miller, showing a glimpse of the future. With Colorado sitting at 3-6 overall and 1-5 in the Big 12, the focus now shifts to salvaging pride and evaluating young talent.
The Buffaloes’ offense has been inconsistent all season, and the quarterback carousel hasn’t helped. Kaidon Salter started against Arizona but was benched after a rough first half, while Ryan Staub also struggled before Lewis got his chance. Miller has been the most reliable weapon, leading the team in receiving yards and touchdowns, and his chemistry with Lewis could be something to build on. The run game has been pedestrian, with Micah Welch leading the way but rarely finding much room behind an offensive line that has struggled in protection and push. If Colorado is going to hang around in Morgantown, it will need to limit mistakes and find a way to sustain drives.
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Defensively, Colorado has been overwhelmed in recent weeks. They gave up over 400 yards to Arizona, including 213 through the air and 204 on the ground, and the tackling issues were glaring. Penalties have also been a killer, with 14 flags against the Wildcats wiping out big plays and extending drives. Safety Tawfiq Byard and linebacker Jeremiah Brown have been among the few steady contributors, but the unit as a whole has struggled to get stops. Against a West Virginia team that just ran for nearly 250 yards in its upset of Houston, the Buffaloes’ front seven will be tested again.
Mountaineers Shock Houston On The Road
West Virginia enters this matchup with renewed confidence after snapping a five-game losing streak in impressive fashion, knocking off No. 22 Houston 45-35 on the road. Freshman quarterback Scotty Fox Jr. was the story, accounting for three touchdowns—one through the air and two on the ground—while showing poise beyond his years. He threw for 157 yards and added 65 rushing yards, including a 34-yard touchdown run that sealed the game. The Mountaineers also leaned on their ground game, with Diore Hubbard rushing for 108 yards and a score, and Cyncir Bowers adding 65 yards and a touchdown. That balance gave West Virginia its best offensive performance of the season.
The Mountaineers’ offense has been at its best when it can control tempo with the run game, and that formula worked perfectly against Houston. Fox’s dual-threat ability adds another dimension, forcing defenses to account for his legs as well as his arm. Wide receiver Cam Vaughn remains the top target, hauling in a 24-yard touchdown in the win, and his ability to stretch the field opens up space for the backs. If West Virginia can replicate that balance against Colorado, it will put the Buffaloes’ struggling defense in a bind.
Defensively, West Virginia made timely plays against Houston, forcing four turnovers and turning them into 17 points. Cornerback Jaden Scruggs delivered the highlight with an 80-yard pick-six that swung momentum in the third quarter. The Mountaineers still gave up 35 points, so there’s work to be done, but the opportunistic nature of the defense was a welcome change. At home, with the crowd behind them, West Virginia will look to pressure Colorado’s young quarterbacks and force mistakes. If they can control the line of scrimmage and win the turnover battle again, the Mountaineers are in good position to build on last week’s breakthrough.
Colorado vs West Virginia Pick
Colorado vs West Virginia Spread Pick
- West Virginia -6.5 (2 Units)
West Virginia -6.5 looks like the right side given how the Mountaineers responded in their upset of Houston. Freshman quarterback Scotty Fox Jr. gave them a spark with three total touchdowns, and the ground game was dominant with Diore Hubbard and Cyncir Bowers combining for nearly 175 rushing yards. That balance makes them tough to defend, especially against a Colorado team that has been gashed for over 100 points in its last two outings. Playing at home in Morgantown, West Virginia should be able to control tempo, lean on its run game, and keep Fox comfortable in the pocket.
Defensively, the Mountaineers showed they can be opportunistic, forcing four turnovers against Houston, including a game-changing pick-six from Jaden Scruggs. Colorado’s offense has been erratic, cycling through quarterbacks before turning to freshman Julian Lewis, and that inexperience could be exposed against a defense that thrives on pressure. If West Virginia can win the turnover battle again and keep Colorado’s offense one-dimensional, the Mountaineers have the tools to cover the number and build on last week’s breakthrough.
Colorado vs West Virginia Over/Under Pick
- Over 55 (2 Units)
The over 55 looks appealing because both teams have shown they can get into shootouts—Colorado gave up 52 points to Arizona last week while still flashing big-play ability with freshman QB Julian Lewis, and West Virginia just dropped 45 on Houston behind a balanced attack that piled up nearly 250 rushing yards. The Buffaloes’ defense has struggled to slow anyone down, while the Mountaineers’ opportunistic style can create short fields and quick scores. With Colorado capable of striking through the air and West Virginia leaning on its ground game and dual-threat quarterback, this matchup has all the ingredients for a high-scoring affair that clears the number.
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