Duke vs. Virginia, Odds, Preview, Picks and Prediction for Saturday, December 6, 2025
Use Code WWWC It’s the ACC Championship Game on the gridiron in the Tar Heel State as the Ds travel to face the #14 Virginia Cavaliers Saturday night and we have you covered with our Wake Forest vs. Louisville prediction. Duke dropped Wake Forest 49-32 at home in their previous contest last Saturday, covering the line as a two-point favorite. Virginia took down Virginia Tech 27-7 at home last Saturday, covering the line as a 7.5-point favorite, in their previous game. In the all-time series between the teams, the Cavaliers own a 42-34 advantage and have taken the last two meetings, including a 34-17 road win in the most recent matchup on November 15, 2025. Read more about this Duke vs. Virginia prediction! Don’t get penalized! Increase your bankroll with our NCAAF Betting Picks!
Duke Seeking to Avenge Last Month’s Loss to Virginia
Duke bounced back from losing three of four as they claimed their final two games of the season, downing North Carolina and Wake Forest, to earn their way into the ACC title game. The Blue Devils improved to 7-5 overall and 6-2 in the ACC. They earned the spot in a five-way tie with SMU, Miami, Pitt and Georgia Tech based on the fifth tiebreaker because of a higher conference opponent winning percentage. Against Wake Forest, Duke led 14-3 after the opening quarter and 21-17 at the half before scoring the first two touchdowns of the second half to go up 35-17. The Blue Devils never let the Demon Deacons closer than 10 the rest of the way. Duke was outgained 466-378 in total offense and gave up 27 first downs while recording 24 in the game. The Blue Devils owned a 34:39 to 25:21 margin in time of possession and forced four turnovers while not committing any in the victory.
On the year, the Blue Devils are 12th in the nation in passing offense with 289.3 yards per game and 96th in rushing offense as they grind out 132.1 yards per contest on the ground. Duke is 19th in the FBS in scoring offense as they put up an average of 34.6 points per contest while the team is 97th in scoring defense by allowing 29.4 points per game. Darian Mensah is 286 of 424 passing for 3,450 yards with 28 touchdowns and four interceptions on the year, plus a rushing score. Henry Belin IV (two of five, 22 yards, 15 rush yards) is the backup. Nate Sheppard leads the ground game with 157 carries for 865 yards plus nine scores. Anderson Castle (94 carries, 435 yards, 11 TD) and Jaquez Moore (39 carries, 192 yards, TD) are also involved in the mix. Cooper Barkate leads the team with 63 catches for 978 yards and six scores on the season. Que’Sean Brown (52 catches, 665 yards, three TD), Sahmir Hagans (35 catches, 432 yards, six TD), tight end Jeremiah Hasley (31 catches, 385 yards, three TD), Andrel Anthony (26 grabs, 246 yards, five TD) and Sheppard (30 receptions, 235 yards, TD) are all over the 200-yard mark on the year. Todd Pelino is 47 of 47 on extra points and 12 of 17 on field goal attempts with a long of 49 this season.
Key Injury Report for Duke:
- Wide receiver Andrel Anthony (undisclosed) is questionable.
- Cornerback Landen Callahan (undisclosed) is questionable. (31 tackles, pass defense)
- Safety Terry Moore (knee) is questionable. (71 tackles, sack, 2 FF, four INT, five pass defenses)
Cavaliers Look to Earn ACC Crown
Virginia won their second straight game as they beat Virginia Tech to take the regular-season crown in the ACC last week. The Cavaliers improved to 10-2 overall and 7-1 in the ACC on the season as they take the field here. Against Virginia Tech, Virginia led 7-0 after the opening quarter, 14-0 at the half and 24-0 after three quarters en route to the win. The Cavaliers didn’t let the Hokies score until less than five minutes remained in the contest. Virginia rolled up a 380-197 advantage in total offense, picked up 25 first downs while allowing six, controlled the clock by a 36:56 to 23:04 margin and forced the game’s two turnovers in the win.
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The Cavaliers are 53rd in the nation in passing offense with 244.5 yards per game, while they are 34th in rushing offense with 188.7 yards per contest on the ground. Virginia is 27th in the FBS in scoring offense with 33.2 points per game, while they are 24th in scoring defense by allowing 20 points per contest. Chandler Morris is 236 of 358 passing for 2,586 yards with 14 touchdowns and seven interceptions while adding 248 yards and five scores on the ground. Daniel Kaelin (30 of 52, 339 yards, TD, INT, 72 rush yards) and Cole Geer (two of two, eight yards, 15 rush yards) are next up on the depth chart. J’Mari Taylor leads the team with 207 carries for 997 yards and 14 scores this year. Harrison Waylee (87 carries, 422 yards, five TD), Xavier Brown (51 carries, 241 yards, TD) and Noah Vaughn (23 carries, 174 yards) are also effective in the run game. Cam Ross is second on the team with 43 catches for 459 yards and two scores this season. Trell Harris (56 receptions, 809 yards, five TD), Jahmal Edrine (39 grabs, 484 yards, TD), Taylor (39 catches, 219 yards), tight end Sage Ennis (18 grabs, 179 yards, five TD), Dakota Twitty (11 receptions, 129 yards) and Kameron Courtney (23 catches, 226 yards) are over the 125-yard mark in receiving yards. Will Betridge has hit all 46 extra point attempts and 20 of 24 field goal attempts with a long of 47 this season.
Key Injury Report for Virginia:
- Running back Xavier Brown (knee) is out.
- Running back Noah Vaughn (undisclosed) is out.
- Linebacker Kam Robinson (knee) is out. (64 tackles, two sacks, FR, two INT, pass defense, two TD)
Betting Trends for Duke vs. Virginia:
Duke is:
- 1-9 ATS last 10 vs. UVa.
Virginia is:
- 7-3 ATS last 10 games.
- 7-0 Under last 7 games.
Duke vs. Virginia Prediction
Spread Pick for Duke vs. UVA
- Virginia -3.5 (4 units)
These teams met in Durham last month and the Cavaliers dropped the hammer on the Blue Devils, rolling to a 17-3 lead at the half and a 31-3 edge after three quarters en route to the 34-17 win. Virginia piled up 540 yards of offense, outrushing Duke 224-42, as they dominated. The Cavaliers are missing two of their running backs but they still have Taylor and Waylee to lead the way on the ground. Duke could be banged up in the secondary and they struggled to move the ball with any consistency in that contest. The Blue Devils are just happy to be here, while Virginia looks to add the conference championship title to their regular-season crown. Look for Morris to lead the Hoos to victory.
Over/Under Pick for Duke vs. UVa
- Under 57.5 (4 units)
Duke has seen the over post a 9-3 mark in their 12 games this season. The Blue Devils are an excellent offensive squad though they have had defensive issues. Duke cracked the 30-point mark eight times during the season while allowing the opposition to score at least 30 points seven times. Virginia has seen the under post a 6-5-1 mark on the year, but they have been under machines of late. After starting the year with five straight overs, the under is 6-0-1 in the Cavaliers’ last seven games. We saw these teams combine for 51 points against a total of 60 last month and this one ends up falling short of the number.
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