Eastern Michigan vs. Buffalo, Picks and Prediction, Saturday, October 4, 2025

By: Bosun Akinpelu Published 10/02/2025, 06:09 PM ET
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Eastern Michigan (1-4, 0-1 MAC) will be trying to pick up their first road win of the season when they visit UB Stadium on Saturday afternoon to face Buffalo (2-3, 1-0 MAC) at 3:30 PM. ET. Read on to find out which team picks up the win in this Eagles vs. Bulls prediction.

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The Eagles are coming off a 24-13 loss to Central Michigan as three-point underdogs. The Bulls are coming off a 20-17 loss to UConn as three-point underdogs.

Eastern Michigan and Buffalo have split their last 10 meetings. The Bulls won last season’s meeting, 37-20.

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Eastern Michigan Trying To Snap Three-Game Road Losing Streak

The Eagles followed up their win over Louisiana on Sept. 20 with a loss to Central Michigan last week by 11, giving them their third consecutive road loss. They will try to put an end to the streak and pick up their first road win of the season when they play on Saturday. They allowed 306 yards rushing against the Chippewas and rushed for just 123 yards on 29 carries.

Eastern Michigan averages 24 points per game, which is 96th in the country. They throw for 233.6 yards and rush for 140.4 yards per game.

Noah Kim has completed 63 percent of his passes for 1,168 yards, five touchdowns, and three interceptions. He also has 73 rushing yards and three touchdowns. Dontae McMillan leads the team with 62 carries for 416 yards and one touchdown, while Terry Lockett Jr. leads the team with 19 catches for 263 yards and one touchdown.

Eastern Michigan is giving up 36.6 points per game, which is 128th in the country. They are giving up 205.3 passing yards and 292.3 rushing yards per game.

Buffalo Trying To Snap Two-Game Losing Streak

The Bulls followed up their two-game winning streak with losses to Troy and UConn. They will try to snap their losing streak and pick up their second conference win of the season when they play on Saturday.

Buffalo averages 24 points per game, which is 96th in the country. They throw for 167.2 yards and rush for 176.4 yards per game.

Ta’Quan Roberson has completed 62 percent of his passes for 662 yards, five touchdowns, and two interceptions. He also has 155 rushing yards and two touchdowns. He missed their last game against UConn due to injury, but is listed as probable for this game. Gunnar Gray led the Bulls to the win over UConn, passing for 174 yards (23 of 44), with one TD and one pick. Al-Jay Henderson leads the team with 96 carries for 337 yards and four touchdowns, while Victor Snow leads the team with 23 catches for 274 yards and three touchdowns.

Buffalo is giving up 19.6 points per game, which is 45th in the country. They are giving up 231.5 passing yards and 156.3 rushing yards per game.

Eastern Michigan vs. Buffalo Picks

Point Spread Pick for Eastern Michigan vs. Buffalo

  • Buffalo Bulls -9.5 (4 Units)

The Bulls have lost three of their five games, while the Eagles have lost four of their five games. Buffalo has the edge here because they have a dominant ground game. They’re facing one of the worst teams in the nation when it comes to defending the run, giving up more than 290 yards per game on the ground, so expect them to control possession in this game by keeping the ball on the ground and pounding Eastern Michigan’s defense into submission.

Eastern Michigan won’t be as successful offensively because they don’t run the ball well and relies heavily on their passing game. The Bulls have a good run defense and will be able to slow the Eagles down on the ground, which will allow them to keep pressure on Kim and force him to make costly mistakes. Go with Buffalo to cover the spread.

Over/Under Pick for Eastern Michigan vs. Buffalo

  • Under 54.5 (4 Units)

The Bulls played under the total in five of their last seven games, while the Eagles played under the total in two of their last four games. Buffalo averages 24 points per game. They run the ball 52 percent of the time with the 56th-best ground game in the country. They are facing a team that is 134th against the run and is giving up 36.6 points per game. The Eagles average 24 points per game. They throw the ball 52 percent of the time with the 67th-best passing attack in the country. They are facing a team that is 72nd against the pass and is giving up 19.6 points per game. Don’t expect these teams to score enough points to push the score over the total.

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