Georgia Southern vs USC Picks and Prediction for Saturday, September 6, 2025
The Georgia Southern Eagles (0-1) pay a visit to Southern California on Saturday to play the USC Trojans (1-0) at the Los Angeles Memorial Coliseum. Georgia Southern opened its regular season with a 42-14 loss on the road to the Fresno State Bulldogs. USC opened its regular season with a 73-13 rout of the Missouri State Bears. Georgia Southern does not have any players listed on its injury report. USC has seven players listed as questionable. Make sure to read this in-depth Georgia Southern Eagles vs USC Trojans prediction. Buckle up! Dive into our top NCAAF picks for Georgia Southern Eagles vs. Southern California (USC) Trojans prediction and dominate your wagers.
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Georgia Southern needs substantial Improvement on both sides of the ball
The Georgia Southern Eagles scored 14 points in their first game of the season, with 84 yards rushing and 158 yards passing for 242 yards of total offense. The Georgia Southern defense gave up 42 points to Fresno State, on 351 yards rushing and 176 yards passing for 527 yards. The Eagles allowed five rushing touchdowns.
Georgia Southern quarterback JC French IV has 158 yards passing with two touchdowns and one interception. OJ Arnold leads the Eagles on the ground with 41 yards. Camden Brown has a team-best 55 yards receiving with one touchdown reception, and Josh Dallas is second with 48 yards. Georgia Southern has not scored on the ground but has two touchdowns through the air. On defense, DB Jayden Davis has a team-high 10 tackles. Georgia Southern has not made any quarterback stats, but has intercepted two passes.
USC is playing well both on offense and defense
The USC Trojans performed exceptionally well on offense in their opening game this season, scoring 73 points, with 233 yards rushing and 364 yards passing for 597 yards of total offense. USC scored six touchdowns on the ground and three through the air. The USC defense gave up 13 points in its victory over Missouri State, allowing 65 yards rushing and 159 yards passing for 224 yards.
USC quarterback Jayden Maiava has 295 yards passing with two touchdowns. Backup QB Husan Longstreet has 69 yards passing with one touchdown. King Miller leads USC in rushing with 80 yards and one touchdown, while Longstreet has 54 yards rushing and two touchdowns. Makai Lemon is the leading receiver with 90 yards, while Eli Sanders is second with 73 yards and one touchdown reception. On defense, linebacker Elijah Newby has a team-best five tackles. USC’s defense has made five quarterback sacks and intercepted two passes.
Georgia Southern vs. USC Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Earle Sports Bets | +2,298.00 |
| 2 |  Ross Benjamin | +1,840.00 |
| 3 |  Rob Vincilleti | +1,757.00 |
| 4 |  David Hess | +1,745.00 |
| 5 |  Dan Kaiser | +987.00 |
Spread Pick for Georgia Southern vs. USC (4 units)
- USC Trojans to cover
The USC Trojans will be far too much on both sides of the line of scrimmage for the Georgia Southern Eagles to compete. USC used a balanced attack on offense to generate 73 points in its opening game victory over Missouri State. USC rushed for 233 yards, passed for 364 yards, and will face a Georgia Southern defense that gave up 351 yards rushing and 176 yards passing. USC will use its above-average running attack to set up its passing game, which will create plenty of scoring for the Trojans. USC gave up just 224 yards of total offense to Missouri State, including only 65 yards rushing, which will produce plenty of three-and-outs for Georgia Southern on Saturday. USC will have a big spread to cover, currently at just over four touchdowns at -29, but the Trojans have the skill-position players to easily produce plenty of points, evidenced by their 60-point victory over Missouri State.
Over/Under Pick for Georgia Southern vs. USC (5 units)
- Over
USC scored 73 points in its opening game of the season, and a combined 86 points were scored in that game, which easily finished over a closing line of 59.5 points. Georgia Southern is weak on defense and will give up plenty of points on the road to the Trojans. USC may even score enough points for the total to finish over with just their scoring. Fifty-four points were scored in Georgia Southern's opening game loss to Fresno State, which finished over a 49-point closing line.
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