Jacksonville State vs. Southern Mississippi, Picks and Prediction, Saturday, September 27, 2025

By: Bosun Akinpelu Published 09/25/2025, 04:58 PM ET
Gamecocks vs. Golden Eagles prediction
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Jacksonville State (2-2, 1-0 C-USA) will be going for their second consecutive win when it visits M.M. Roberts Stadium on Saturday night to face Southern Mississippi (2-2, 1-0 Sun Belt) at 7 PM. ET. Read on to find out which team picks up the win in this Gamecocks vs. Golden Eagles prediction. Don’t get penalized! Increase your bankroll with our NCAAF Betting Picks!

The Gamecocks are coming off a 45-10 win over Murray State as 35.5-point favorites. The Golden Eagles are coming off a 30-20 loss to Louisiana Tech as three-point underdogs.

Jacksonville State won the lone meeting between the two teams last season, 44-7.

Jacksonville State Trying To Snap Two-Game Road Losing Streak

The Gamecocks have won two of their first four games, with both losses coming on the road. They are hitting the road for the third time this season and will try to put an end to their losing streak with a win on Saturday.

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Jacksonville State averages 30.8 points per game. They throw for 148.5 yards and rush for 261.5 yards per game.

Gavin Wimsatt has completed 56.3 percent of his passes for 557 yards, two touchdowns, and two interceptions. He also has 216 rushing yards and four touchdowns. Cam Cook leads the team with 89 carries for 537 yards and four touchdowns, while Brock Rechsteiner has 13 catches for 191 yards and two touchdowns.

Jacksonville State is giving up 27.3 points per game, which is 70th in the country. They are giving up 280 passing yards and 176 rushing yards per game.

Southern Mississippi Trying To Bounce Back From Loss

The Golden Eagles had their two-game winning streak snapped by Louisiana Tech in their last game. They will try to bounce back from the loss and pick up their third win in five games when they play on Saturday.

Southern Mississippi averages 28.3 points per game, which is 82nd in the country. They throw for 273.5 yards and rush for 118.3 yards per game.

Braylon Braxton has completed 66 percent of his passes for 1,084 yards, nine touchdowns, and three interceptions. He also leads the team with 128 rushing yards. Jefferey Pittman has 25 carries for 126 yards and two touchdowns, while Carl Chester leads the team with 13 carries for 211 yards.

Southern Mississippi is giving up 26.5 points per game, which is 86th in the country. They are giving up 297.7 passing yards and 127.3 rushing yards per game.

Jacksonville State vs. Southern Mississippi Pick

Point Spread Pick for Jacksonville State vs. Southern Mississippi

  • Southern Mississippi Golden Eagles -4 (4 Units)

The Gamecocks and Golden Eagles split their first four games. Southern Mississippi has the edge in this game because they have one of the best passing games in the country, and they’re facing a defense that has been unable to stop the pass so far, giving up more than 275 passing yards per game, so expect them to air the ball out.

Jacksonville State loves to keep the ball on the ground, but they won’t be able to get much going in this game because the Golden Eagles have done a great job of defending the run, giving up less than 130 yards per game on the ground, so expect them to stack the box and force Wimsatt to beat them with his arm, which isn’t going to happen. Go with Southern Mississippi to cover the spread.

Over/Under Pick for Jacksonville State vs. Southern Mississippi

  • Over 54.5 (4 Units)

The Gamecocks and Golden Eagles both played over the total in two of their last three games. Jacksonville State averages 30.8 points per game. They run the ball 65 percent of the time with the 11th-best ground attack in the country. They are facing a team that is 45th against the run and is giving up 26.5 points per game. The Golden Eagles average 28.3 points per game. They throw the ball 56 percent of the time with the 22nd-best passing attack in the country. They are facing a team that is 116th against the pass and is giving up 27.3 points per game. Expect these teams to score enough points to push the score over the total.

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