Kentucky Wildcats at Vanderbilt Commodores, Picks, Odds, Preview, and Prediction, Saturday, November 22, 2025
Use Code WWWC It’s a major SEC clash that has postseason implications on Saturday, Nov. 22. Read our Kentucky vs Vanderbilt prediction along with the rest of our other NCAAF Betting Picks. Kentucky is 5-5 and with a win can become bowl eligible. The Wildcats have won three straight games, highlighted by wins over Auburn and Florida. Vanderbilt is 8-2, and they are the No. 14 team in the nation. They kept their College Football Playoff hopes alive by defeating Auburn in overtime last week. These two teams will meet with kick-off set for 3:30 P.M. EST.
Kentucky riding a 3-game winning streak
Kentucky is 5-5 overall this season. They are currently holding a 2-5 SEC record, too. The Wildcats are 1-2 when they have played on the road. After losing four straight games, the Wildcats have won three straight games as they have defeated Auburn, Florida and Tennessee Tech.
In their last game, Kentucky defeated Tennessee Tech 42-10 at home on Saturday, Nov. 15. Kentucky secured the easy win by accumulating 468 yards of offense while their defense allowed just 264 yards. Quarterback Cutter Boley threw for 236 yards on 18-for-21 passing with a touchdown. Running back Dante Dowdell led the team with 87 yards, and he scored a touchdown. It was a big game for Seth McGowan, who finished with three touchdowns and 72 yards.
Boley has thrown for 1,780 yards this season and has completed 69% of his passes. He has thrown 13 touchdowns and eight interceptions. McGowan is the lead back with 693 yards and 12 touchdowns on the season. Wide receiver Kendrick Law has a team-high 519 receiving yards with three touchdowns.
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On defense, Kentucky is led in tackles by defensive back Ty Bryant with 56 tackles. Steven Soles Jr. leads the team with 3.5 sacks. The defense has forced 12 turnovers on the year, with Bryant leading the team with three picks.
Kentucky is averaging 25.9 points per game, which ranks 80th. They are averaging 203.9 passing yards per game, which ranks 99th. The Wildcats are the 68th-ranked rushing offense, averaging 159.9 yards per game.
On defense, Kentucky is allowing 23.1 points per game, which ranks 50th. They are the 36th-ranked rushing defense, giving up 128.8 yards per game on the ground. The Wildcats are allowing 215.8 pass yards per game, placing them 57th.
Betting Trends for Kentucky
- Kentucky is 5-5 against the spread this season.
- The over is 7-3 when Kentucky has played this season.
- The over is 3-0 when the total has been set at 50 points or higher.
Vandy still pushing for College Football Playoff berth
Vanderbilt is 8-2 overall this season. The Commodores have a 4-2 SEC record that has the team tied for fifth place in the league. They are the No. 14 team in the nation, just a few spots out of a College Football Playoff berth. After losing to Texas by a field goal, Vanderbilt was able to bounce back with a home win last week.
In their last game, Vanderbilt defeated Auburn 45-38 in overtime at home on Saturday, Nov. 15. The Commodores trailed 17-3 in the second quarter. They were able to score 14 unanswered points in the fourth quarter to take a 38-30 lead. Auburn tied the game in the final five minutes of the game to send it to overtime. Vanderbilt earned the win as quarterback Diego Pavia threw a short touchdown pass to Cole Spence for the win.
Pavia threw for 377 yards on 25-for-33 passing and three touchdowns. Pavia also rushed for a team-high 112 yards and a touchdown in the win. Tre Richardson was the leading receiver with 124 yards, three catches and a touchdown.
Pavia has thrown for 2,440 yards and has completed 70% of his passes for 21 touchdowns and five interceptions. Pavia has recorded a team-high 613 yards and seven touchdowns on the ground, too. Eli Stowers has a team-high 669 receiving yards and four touchdowns on the year.
On defense, Vanderbilt is led in tackles by linebacker Bryan Longwell with 58. Miles Capers has a team-high 4.5 sacks on the year, too. The defense has forced 11 turnovers on the season, too.
Vanderbilt is averaging 38.3 points per game, which ranks ninth best in the nation. They rank 43rd in passing offense with 258 passing yards per game. The Commodores are rushing for 185 yards per game, which places them 39th.
On defense, Vanderbilt is allowing 22.2 points per gam,e which ranks 43rd. They are allowing 244.7 passing yards per game, placing them 104th. Vanderbilt ranks 24th in rush yards per game, as they are allowing 112.5 yards per game.
Betting Trends for Vanderbilt
- Vanderbilt is 7-2-1 against the spread this season.
- The Commodores are 5-1 against the spread when they have played at home.
- They are also 5-1 against the spread as favorites.
- The over is 4-2 when Vanderbilt has played at home.
Kentucky Wildcats vs Vanderbilt Commodores Picks
Kentucky vs Vandy Spread Pick and Prediction
- Vanderbilt -9 (5 units)
It’s a big game for Vanderbilt as they look to continue their quest to qualify for the College Football Playoff. They survived a test against Auburn in their last game, where they needed overtime to secure the win. This week, they should come out of the gates fast and take down a Kentucky team that has struggled at times in SEC play. The Wildcats have won three straight games, but Vanderbilt will be the best team that they have faced during this stretch. Diego Pavia is continuing his Heisman campaign and he will need another big performance, which he will deliver versus Kentucky’s 57th-ranked pass defense. Vanderbilt is 5-1 against the spread as a favorite and at home this year. Kentucky is 1-2 against the spread when playing on the road.
Take Vanderbilt to cover.
Kentucky vs Vanderbilt Over/Under Pick
- Over 53 points (5 units)
Vanderbilt’s offense is built on big plays and scoring tons of points. The offense is averaging 38.3 points per game which is the ninth-best mark in the nation. They also need style points, so if they have a lead over Kentucky, they will continue to hammer the Wildcats all game long. Kentucky’s offense has improved recently, too. They have scored at least 38 points in back-to-back games. The over is 3-0 when the total has been set at 50 points or higher for Kentucky games. The over is 4-2 when Vanderbilt has played at home.
Take the over on Saturday.
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