Maryland vs. Illinois, Odds, Preview, Prediction and Picks, Saturday, Nov. 15, 2025

By: Ben Hayes Published 11/13/2025, 07:07 PM ET
Maryland vs. Illinois prediction and pick
Use Code WWWC

A Big 10 matchup is on tap in this Maryland vs. Illinois prediction. The weather is projected to be very warm for a mid-November day in Champaign, Illinois, as the temperatures are expected to be in the low 70s by game time at 3:30pmET. Maryland (4-5, 1-5 B10) is hoping to break a five-game losing streak when they face the Illini (6-3, 3-3 B10), who is tied with Washington, Northwestern and UCLA for ninth place in the Big 10. Need more winners in college football and the other seven sports? We cover most of them at Winners and Whiners.

Quick Picks and Prediction on Maryland vs. Illinois

Here is a quick guide to what you're looking for if you are in a hurry.

  • Illinois 38-Maryland 20
  • Illinois -14.5
  • Over 53.5

Maryland vs. Illinois Odds and Line Movement

  • The opening odds and current odds are listed below for Maryland vs. Illinois.
  • You can also find the line moves for Maryland vs. Illinois

Opening Odds for Maryland vs. Illinois

  • Illinois opened as a 14.5-point favorite (-105)
  • The money line opened at Illinois -690 and Maryland +480
  • The total opened at 54.5 (-110)

(odds from FanDuel)

Maryland vs. Illinois Line Movement

  • The Spread moved from Illinois -14.5 (-105) to -14.5 (-110)
  • The Money Line moved from Maryland +480 to +520, while Illinois jumped from -690 to -750
  • The total moved from 54.5 (-110) to 53.5 (-110)

Key Matchups for Maryland vs. Illinois

Terps going through a rough stretch

Maryland has a young team with a true freshman quarterback in Malik Washington and a coach in Mike Locksley, who could be on the hot seat. His team opened up at 4-0 with a pretty soft schedule, and then when the going got tough, the Terps have not responded. It began with close losses to Washington, Nebraska, and UCLA (by a combined 10 points), which were all winnable games. They were pounded by Indiana 55-10 on Nov. 1 and then last week, were crushed by lowly Rutgers 35-20.

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Washington has hit a wall as a passer, completing just 15 of 28 last week for 98 yards with a TD and a pick. He might have found a groove as a runner (164 yards, 1 TD), which is something that Maryland could use, considering that they've been pretty bad this season, as their leading rushing Dejuan Williams (366 yds) averages just 3.6 yards per carry. Washington is completing 58.4% of his passes for 2,056 yards with 13 TDs and six INTs.

Illini coming off a bye

Illinois, like Maryland, also faced Rutgers in their last game on Nov. 1. Unlike Maryland, they defeated the Scarlet Knights 35-13, which broke a two-game losing streak. QB Luke Altmyer completed 19 of 31 for 235 yards with four TDs and a pick. He also rushed for 88 yards and a TD. The offense rushed for 210 yards and had the ball for 32:35.

Altmyer is completing 70% of his passes for 2,255 yards with 19 TDs and just four INTs. He's also run for three touchdowns on the season. Hank Beatty is his top target with 49 catches for 730 yards and three touchdowns. On defense, OLB Gabe Jacas leads the Illini with 6.5 sacks and two forced fumbles.

Maryland

  • 6-3 Under last 9 games.

Illinois

  • 10-3 ATS last 13 games.
  • 4-2 Over last 6 games.
  • 5-1 ATS last 6 at home.

Key Injuries and Analysis for Maryland vs. Illinois

Maryland:

  • Ryan Manning (undisclosed) is questionable.
  • OG J. Gilchrist (undisclosed) is questionable

Illinois:

No key injuries to report

Maryland vs. Illinois ATS and Over/Under Betting Picks

Check out the spread and total below. There should be some points scored on a rare warm day in Illinois in November. Luke Altmyer goes up against young QB Malik Washington, who has started to use his legs to move the chains.

Maryland vs. Illinois Spread

  • Illinois -14.5 (5 units)

Total for Maryland vs. Illinois

  • Over 53.5 (4 units)

Maryland vs. Illinois Final Score Prediction

  • Illinois 38-Maryland 20

The big issue here is Maryland's defense and I probably went conservative on the score since Illinois is coming off a bye and should be fresh. The Terps are struggling on the defensive side of the ball, allowing 392.4 yards overall and 226.6 passing yards. Rutgers destroyed them on the ground last week, rushing for 256 yards. That's a bad sign for Saturday against a better offense and overall team.

 

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