Missouri Tigers vs. Vanderbilt Commodores Picks and Prediction for Saturday, October 25, 2025
Use Code WWWC It’s a battle of ranked SEC foes from the Volunteer State on the gridiron as the #15 Missouri Tigers are on the road to battle the #10 Vanderbilt Commodores Saturday afternoon and we have you covered with our Missouri vs. Vanderbilt prediction. Missouri edged Auburn 23-17 in double overtime in their previous contest last Saturday, covering the line as a 1.5-point favorite, in their previous contest. Vanderbilt upended #10 LSU 31-24 at home in their previous game last Saturday, covering the line as a 1.5-point favorite. In the all-time series between the teams, the Tigers own an 11-4-1 advantage and have won the last five meetings, including a 30-27 home win in the most recent matchup on September 21, 2024. Read more about this Missouri vs. Vanderbilt prediction! Don’t get penalized! Increase your bankroll with our NCAAF Betting Picks!
Missouri Looking to Best Commodores for Sixth Straight Time
Missouri managed to outlast Auburn in double overtime on the road in their previous contest last Saturday. The Tigers improved to 6-1 overall and stand 2-1 in SEC play on the season, leaving them tied for fifth in the conference. Against Auburn, Missouri trailed 7-3 after the opening quarter, led 10-7 at the half, trailed 14-10 after three quarters and 17-10 in the fourth quarter before rallying to force overtime. In the second overtime, Beau Pribula scored on a three-yard run, and the Missouri defense stopped Auburn on the ensuing possession to earn the win. The Tigers were outgained 357-343 in total offense, picked up 26 first downs while allowing 19 and controlled time of possession by a 32:47 to 27:13 margin in the contest. Missouri did turn the ball over twice while forcing one takeaway in the contest.
The Tigers are 61st in the nation among the 136 FBS teams to take the field this season in passing offense with 241.7 yards per game on the year, while they are 7th in rushing offense with 244.9 yards per contest. Missouri is 12th in the FBS in scoring offense as they put up 39 points per game and the team stands 16th in scoring defense by limiting opposing teams to 16.7 points per contest. Beau Pribula is 149 of 213 passing for 1,617 yards with 11 touchdowns and seven interceptions while ranking third on the team with 210 rushing yards and five scores this season. Matt Zollers is six of six for 75 yards and a score as the backup. Ahmad Hardy leads the team with 139 carries for 840 yards and 11 touchdowns on the year. Jamal Roberts is next in line with 56 carries for 406 yards and three scores. Kevin Coleman Jr. leads the team with 44 receptions for 449 yards and a score. Marquis Johnson (25 catches, 322 yards, two TD), Brett Norfleet (25 grabs, 221 yards, five TD), Joshua Manning (18 catches, 207 yards, TD), and Donovan Olugbode (16 grabs, 202 yards, TD) are all solid targets. Blake Craig is three of three on extra point attempts and two of two on field goal attempts with a long of 55 this year. Robert Meyer is 26 of 28 on extra point attempts and eight of 10 on field goal attempts with a long of 40 this season.
Craig (undisclosed) is done for the season.
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Commodores Shooting to Roll at Home
Vanderbilt bounced back from a loss to Alabama by dropping #10 LSU at home last week, and they look to maintain their success here. The Commodores ran their record to 6-1 overall and stand 2-1 in SEC play, leaving them tied for fifth in the conference. Against LSU, Vanderbilt led 7-3 after the opening quarter, 17-13 at the half and 31-21 after three quarters before hanging on for the victory. The Commodores owned a 399-325 edge in total offense, picked up 20 first downs while allowing 14, and owned a 36:31 to 23:29 edge in time of possession in the contest. There were no turnovers by either team in the contest.
The Commodores enter this contest 58th in the FBS in passing offense with an average of 244.7 yards per game through the air. Vanderbilt is 21st in rushing offense as they average 213 yards per contest on the ground as a team. The Commodores are 8th in the FBS in scoring offense with an average of 41.4 points per game, while they are 35th in scoring defense as they allow an average of 20 points per contest. Diego Pavia is 129 of 183 passing for 1,569 yards with 15 touchdowns against four interceptions. He leads the team with 438 yards and four scores on the ground. Blaze Berlowitz (five of 12, 76 yards, TD, 73 rush yards, TD), Whit Muschamp (two of three, 40 yards, eight rush yards) and Drew Dickey (one of two, 28 yards, 13 rush yards, TD) have also seen action. Sedrick Alexander (63 carries, 361 yards, six TD), Makhilyn Young (27 carries, 296 yards, four TD), and Jamezell Lassiter (eight carries, 144 yards, two TD) are also effective in the ground game. In the passing game, Eli Stowers leads the team with 28 receptions for 355 yards and two scores. Tre Richardson (20 catches, 242 yards, TD), Junior Sherrill (25 grabs, 304 yards, five TD) and Richie Hoskins (14 receptions, 172 yards, TD) are each over the 150-yard mark in receiving yards this season. Brock Taylor is 35 of 36 on extra points and six of six on field goal attempts with a long of 51 this year. Justin Dewers is one of one on extra point attempts, while Mason Rohmiller is two of two. Neither has attempted a field goal.
Dickey (cardiac) is questionable for this contest.
Missouri vs. Vanderbilt Prediction
Spread Pick for Missouri vs. Vanderbilt
- Vanderbilt -2.5 (4 units)
Both teams are off to strong starts this season. Missouri has a bye next week before facing Texas A&M on November 8, while Vanderbilt squares off with Texas next Saturday. The Tigers had their issues at Auburn last week on the road in what was their first game as the visiting team in 2025. Playing in Nashville against a Vanderbilt squad that owns road wins over Virginia Tech and South Carolina in addition to that home win over LSU last week, is going to be a challenge for Mizzou. Last week’s performance wasn’t inspiring for the Tigers. Pavia and the Commodores have been terrific at home, and that carries them to a victory in this contest.
Over/Under Pick for Missouri vs. Vanderbilt
- Over 51.5 (4 units)
Missouri enters this game having seen the over post a 4-3 mark in their seven games on the year. The Tigers have three straight unders after opening the year with four straight overs. Missouri is coming off a season-low in points last week against Missouri, but should have an opportunity to bounce back a bit here. Vanderbilt has seen the over post a 4-3 mark in their seven games on the year. The Commodores have scored at least 31 points in six of their seven games on the year. Three of their four home games have gone over the total. Vanderbilt is a top-10 scoring team and Missouri isn’t far behind. This one has the potential for a shootout and ends up over the total when all is said and done.
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