Nebraska Cornhuskers vs Penn State Nittany Lions Prediction and Picks - November 22, 2025
College football action on Saturday evening, and we have a Nebraska vs Penn State Prediction locked and loaded. The Cornhuskers enter this game at 7-3 on the year and off a solid 28-21 road win over UCLA. Penn State has had a rough year as they have gone 4-6 overall, including just 1-6 in league play. They need to win to keep their slim bowl hopes alive. These teams last met back in 2020, and Nebraska won that game at home by a score of 30-23. Continue reading to see our Nebraska vs Penn State prediction.
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Cornuskers Take Down Bruins On The Road
Nebraska’s last outing came on November 8, when the Huskers went into the Rose Bowl and knocked off UCLA 28-21. Freshman quarterback TJ Lateef was nearly flawless in his first collegiate start, completing 13-of-15 passes for 205 yards and three touchdowns. Running back Emmett Johnson carried the offense with 129 rushing yards and added 103 receiving yards with two scores, giving Nebraska the balance it needed to secure its seventh win of the season.
The Huskers have leaned on Johnson all year, as he’s piled up 1,131 rushing yards and 11 touchdowns while also contributing as a pass catcher. Lateef’s emergence adds another wrinkle to an offense that had been led by Dylan Raiola before his injury. Nebraska’s passing game has been efficient, with Nate Hunter (592 yards, 5 TDs) and Jacory Barney Jr. (403 yards, 4 TDs) providing reliable targets. Overall, the Huskers average 32.5 points per game, ranking 37th nationally, and their ability to protect the football—just nine turnovers all season—has kept them competitive in tight contests.
Defensively, Nebraska has been one of the best units in the Big Ten, allowing just 295.7 yards per game. Their pass defense has been elite, ranking third nationally at 134.6 yards allowed per contest, though the run defense has been more vulnerable at 161.1 yards per game. Still, the Huskers are holding opponents under 20 points per game, and their disciplined approach has made them a tough matchup. Against Penn State, Nebraska’s secondary will be tested, but their ability to force long drives and limit explosive plays gives them a chance to control tempo.
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Earle Sports Bets | +1,154.00 |
| 2 |  David Hess | +868.00 |
| 3 |  Stephen Nover | +634.00 |
| 4 |  Rob Vincilleti | +600.00 |
| 5 |  Dan Kaiser | +547.00 |
The Lions End Long Skid With Win In East Lansing
Penn State snapped a six-game losing streak with a 28-10 win at Michigan State on November 15. Quarterback Ethan Grunkemeyer threw for 127 yards and two touchdowns, both to Devonte Ross, while running back Kaytron Allen delivered a career-best 181 rushing yards and two scores. The Nittany Lions dominated the line of scrimmage, holding Michigan State to just 172 total yards after giving up a touchdown on the opening drive.
Allen has become the focal point of the offense, rushing for 917 yards and 12 touchdowns this season. He’s complemented by Nick Singleton, who has added 419 yards and nine scores, giving Penn State a reliable one-two punch in the backfield. Grunkemeyer has shown flashes in relief, throwing for 689 yards and four touchdowns, while Ross (360 yards, 5 TDs) and Kaden Hudson (245 yards, 2 TDs) headline a receiving corps that has struggled to find consistency. Penn State averages 30.4 points per game, but their passing attack ranks just 114th nationally, making the ground game their clear strength.
Defensively, the Nittany Lions remain formidable, allowing just 316.1 yards per game and ranking 19th nationally. Their pass defense has been excellent, holding opponents to 167.7 yards per contest, while the run defense has been solid at 148.4 yards per game. With only six takeaways, Penn State hasn’t generated many momentum-shifting plays, but their ability to limit big gains has kept them in games. Against Nebraska, the Lions will look to ride Allen’s hot hand and lean on their defense to slow down Johnson and Lateef, hoping to build momentum toward bowl eligibility.
Nebraska vs Penn State Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 | Rob Vincilleti | +1,778.00 |
| 2 |  Ross Benjamin | +1,716.00 |
| 3 | David Hess | +1,326.00 |
| 4 | Earle Sports Bets | +1,323.00 |
| 5 | Dan Kaiser | +1,071.00 |
Nebraska vs Penn State Spread Pick
- Nebraska +8 (3 Units)
Nebraska +8 looks like strong value because the Huskers’ defense is built to frustrate Penn State’s offense. Nebraska ranks third nationally in pass defense, allowing just 134.6 yards per game, and they’ve held opponents under 20 points on average. That matches up well against a Nittany Lions team that has struggled through the air and leans heavily on Kaytron Allen and Nick Singleton to move the chains. With Emmett Johnson carrying the load for Nebraska’s offense and freshman quarterback TJ Lateef showing poise in his debut, the Huskers have enough balance to keep this game tight and within the number.
The betting angle also favors Nebraska. Penn State is just 3-13 ATS when coming off a double-digit straight-up win, and that trend gets even worse at home, where they’re 0-7 ATS in that spot. That history suggests the Lions often fail to cover inflated numbers after a big victory, and Nebraska’s defensive profile makes them a tough opponent to blow out. Getting more than a touchdown with a disciplined Huskers team that protects the football and forces opponents into long drives is a spot worth backing.
Nebraska vs Penn State Over/Under Pick
- Under 45 (2 Units)
The Under 45 feels like the right call because both defenses are built to keep this game in check. Nebraska is allowing just 19.9 points per game and ranks third nationally in pass defense, while Penn State sits at 21.1 points allowed per game with a top‑10 secondary of its own. Neither offense has shown the ability to consistently hit explosive plays, with the Huskers leaning heavily on Emmett Johnson’s ground game and Penn State relying on Kaytron Allen to grind out drives. With two units that thrive on limiting big gains and forcing opponents into long possessions, this matchup sets up as a physical, low‑scoring battle that stays under the number.
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