Ohio State Buckeyes vs Washington Huskies Prediction and Picks - September 27, 2025
Use Code WWWC Big 10 College Football action on Saturday afternoon, and we have an Ohio State vs Washington Prediction locked and loaded for you. The Ohio State Buckeyes are the Top-Ranked team in the nation with a 3-0 record, and they come in off a 37-9 home win over Ohio two weeks ago. Washington enters this contest off a 59-24 road win over Washington State to move to 3-0 on the year. These teams met back in 2019, and Ohio State won 28-23. Can Washington get a measure of revenge for that loss? Continue reading to see our Ohio State vs Washington prediction.
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Buckeye Crush In-State Rival Ohio
Ohio State enters this matchup off a dominant 37–9 win over Ohio, where quarterback Julian Sayin completed 25 of 32 passes for 347 yards and three touchdowns. The Buckeyes balanced their attack as well, with freshman Bo Jackson rushing for 109 yards on just nine carries, and wideout Jeremiah Smith hauling in 9 catches for 153 yards and a touchdown. That result improved Ohio State’s start to 3–0, and showed their offense can both strike deep and grind methodically. On defense, OSU looked aggressive and disciplined, limiting Ohio’s offense to 9 points and controlling third-down opportunities throughout the game. (ESPN preview)
Statistically, Ohio State boasts an efficient offense and stingy defense so far. Via ESPN’s team stats, Sayin has thrown for 779 yards, with 8 touchdowns and 3 interceptions, ranking among the Big Ten’s top passers. On the ground, they’ve also found balance, with Bo Jackson leading the rushing corps with 217 yards to date. Receiving targets like Smith have produced in volume—Smith himself has racked up 315 receiving yards and multiple scores. Defensively, the Buckeyes have tightened in the red zone and limited big plays; they’re particularly effective in pressure situations and have shown a capacity to rally at key moments. (ESPN stat lineup)
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To win this game on the road at Husky Stadium, Ohio State must execute in three phases. Offensively, they’ll need early balance—if defenses overcommit to stopping the run, the passing game must terrorize seams behind them. Protecting Sayin is crucial, especially given the hostile Seattle environment. Defensively, OSU must disrupt Washington’s run game—containing Jonah Coleman and keeping him from breaking into the secondary. Against Washington’s dual-threat quarterback Demond Williams Jr., they must also remain disciplined in coverage and avoid overpursuit. Special teams and field position will matter; Ohio State should aim to exploit any mistakes and maintain consistency over the four quarters to control tempo.
Washington Detroys Washington State
Washington rolls into this showdown also at 3–0, coming off an emphatic 59–24 win over Washington State, in which quarterback Demond Williams Jr. threw four touchdown passes and ran for another score. Williams currently leads the team with 778 passing yards, and the dual-threat nature of his game—he’s added 220 rushing yards—makes him a constant challenge for defenses. In the receiving game, Denzel Boston has accumulated 249 yards and three scores, while running back Jonah Coleman has already posted 347 rushing yards and leads FBS in total touchdowns with nine. (ESPN team stat page)
Offensively, Washington is built for tempo and explosiveness. The Huskies average high yardage totals thanks to their ability to hit both the perimeter and the interior. Their run-pass balance keeps defenses off balance, and Williams’s legs give them an added weapon. On defense, Washington has shown promising signs: they’ve forced turnovers, limited big plays, and exhibited discipline in coverage. The front seven has played fast, and their secondary has created disruption without sacrificing integrity. Still, against elite offenses, they’ll need to show consistency across all four quarters. (ESPN stats)
To pull off a win against Ohio State, Washington must lean into their strengths. Sustain offensive drives with their run game, open passing lanes off play-action, and make OSU’s defense defend horizontally. Defensively, they must slow down Ohio State’s explosiveness—especially limiting Jeremiah Smith and closing off deep options. Containing elite runners and forcing Ohio State into third-and-long will be critical. Home crowd energy and quick-strike scoring could tilt momentum toward the Huskies, but they can’t allow OSU to dominate the line of scrimmage or control the clock. Washington must balance aggression with patience.
Ohio State vs Washington Pick
Ohio State vs Washington Spread Pick
- Washington +8 (5 Units)
Taking Washington +8 offers value because the Huskies’ balance on offense makes them tough to separate from, even against a powerhouse like Ohio State. Quarterback Demond Williams Jr. has already shown his dual-threat ability with nearly 1,000 total yards through three games, while Jonah Coleman continues to power the run game with efficiency and explosive plays. That combination not only helps sustain drives but also keeps opposing defenses guessing, which is key against a Buckeyes team that thrives when it can dictate tempo. With playmakers like Denzel Boston stretching the field, Washington has enough offensive firepower to stay within striking distance and force Ohio State into a four-quarter battle.
There’s also a strong trend backing the Huskies: Washington is 6-0 ATS after scoring 40 points or more when facing an opponent coming off rest. That ATS angle underscores their ability to carry momentum forward, particularly after a dominant offensive outing like their 59-24 win over Washington State. On top of that, Husky Stadium provides one of the toughest environments for visiting teams, and if Washington can feed off the energy while avoiding early turnovers, the cushion of eight points becomes highly appealing. Even if Ohio State’s talent prevails in the end, Washington’s offense and situational track record suggest they’re primed to keep this game well within the number.
Ohio State vs Washington Over/Under Pick
- Under 52.5 (4 Units)
The Under 52.5 looks attractive because both defenses are built to limit explosive plays, even against high-powered offenses. Ohio State has allowed just single digits in two of its three games, and their secondary is athletic enough to keep Washington’s receivers from turning short gains into long touchdowns. On the other side, Washington’s front seven has shown steady improvement and should be capable of containing the Buckeyes’ run game while forcing Julian Sayin to sustain long, methodical drives. With both teams possessing efficient but balanced offenses, the pace is likely to slow at times, especially in a hostile environment where each possession carries weight. That combination of defensive strength and situational football points to a game that grinds under the 52.5 total.
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