Ohio vs. Buffalo, Picks and Prediction, Friday, November 28, 2025
Ohio (7-4, 5-2 MAC) will be trying to keep their conference title hopes alive when they visit UB Stadium on Friday afternoon to face Buffalo (5-6, 4-3 MAC) at 12 PM. ET. Read on to find out which team picks up the win in this Bobcats vs. Bulls prediction. Don’t get sacked this football season! Try our College Football Picks!
The Bobcats are coming off a 42-14 win over UMass as 33.5-point favorites. The Bulls are coming off a 37-20 loss to Miami (OH) as 2.5-point underdogs.
Ohio is 7-3 in its last 10 games against Buffalo. The Bobcats won last season’s meeting, 47-16.
Sign Up for Winners and Whiners News Alerts, Get Free Picks and Discounts
Subscribe Now
Ohio Going For Second Consecutive Win
The Bobcats bounced back from their loss to Western Michigan with a win over UMass in their last game. They are in a four-way tie for second in the MAC standings. With a spot in the conference championship on the line, the Bobcats will secure their spot with a win on Friday.
Ohio averages 28.5 points per game, which is 62nd in the nation. They throw for 191.3 yards and rush for 217.3 yards per game.
Parker Navarro has completed 63 percent of his passes for 2,085 yards, 12 touchdowns, and nine interceptions. He also has 722 rushing yards and seven touchdowns. Sieh Bangura leads the team with 200 carries for 1,123 yards and 13 touchdowns, while Chase Hendricks leads the team with 62 catches for 858 yards and six touchdowns.
Ohio is giving up 22.6 points per game, which is 50th in the nation. They’re giving up 196.2 passing yards and 148.4 rushing yards per game.
Injuries: WR-Eamonn Dennis Undisclosed) is questionable for this game. WR-Max Rodarte (Undisclosed) has been ruled out.
Buffalo Trying To Snap Two-Game Losing Streak
The Bulls followed up their win over Bowling Green with losses to Central Michigan and Miami (OH). They will try to snap their losing streak and become bowl eligible with a win on Friday.
Buffalo averages 23.8 points per game, which is 95th in the nation. They throw for 225.3 yards and rush for 135.3 yards per game.
Ta’Quan Roberson has completed 58 percent of his passes for 2,250 yards, 15 touchdowns, and 11 interceptions. He also has 111 rushing yards and two touchdowns. Al-Jay Henderson leads the team with 177 carries for 724 yards and five touchdowns, while Nik McMillan has 57 catches for 859 yards and three touchdowns.
Buffalo is giving up 22.8 points per game, which is 51st in the nation. They’re giving up 197.5 passing yards and 152.3 rushing yards per game.
Injuries: WR-Bobby Mays (Undisclosed) is questionable for this game. Dwayne Early Jr. (Undisclosed) has been ruled out.
Ohio vs. Buffalo Picks
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Earle Sports Bets | +2,298.00 |
| 2 |  Ross Benjamin | +1,840.00 |
| 3 |  Rob Vincilleti | +1,757.00 |
| 4 |  David Hess | +1,745.00 |
| 5 |  Dan Kaiser | +987.00 |
Point Spread Pick for Ohio vs. Buffalo
- Ohio Bobcats -7 (4 Units)
The Bobcats have won four of their last five games, while the Bulls have lost three of their last four games. Ohio has the edge here because they have one of the best ground games in the nation, and they’re facing a team that hasn’t been able to slow down the run this season, so expect them to keep the ball on the ground.
The Bulls won’t be as successful in this game because they don’t run the ball well and rely heavily on their passing game. The Bobcats have a very good pass defense, and they’re also very good at defending the run, so expect them to keep Buffalo’s offense in check. Go with Ohio to cover the spread.
Over/Under Pick for Ohio vs. Buffalo
- Over 44 (4 Units)
The Bobcats average 28.5 points per game. They run the ball 60 percent of the time with the 16th-ranked ground game in the nation, and they’re facing a team that is 67th against the run and is giving up 22.8 points per game. The Bulls average 23.8 points per game. They throw the ball 55 percent of the time with the 60th-ranked passing attack in the nation, and they’re facing a team that is 26th against the pass and is giving up 22.6 points per game. Expect these teams to score enough points to push the score over the total. The Bobcats and Bulls played over the total in two of their last three meetings.
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Bet $5 & Get $150
