Oklahoma State Cowboys vs. Arizona Wildcats Picks and Prediction, Saturday, October 4th, 2025
Use Code WWWC In this Oklahoma State at Arizona prediction, the two Big 12 combatants square off at Arizona Stadium in Tempe on Saturday afternoon. Oklahoma State enters this game with a record of 1-3, losers of three straight games. The Wildcats are 3-1 on the season as they enter the heart of their Big 12 schedule. The opening kick is scheduled for 3:00 pm EST. Don’t get sacked this football season! Try our College Football Picks!
Oklahoma State is falling hardÂ
The Oklahoma State Cowboys lost for the third straight time last week, this time to Baylor, 45-27. The loss also marked the team’s second straight loss in Stillwater and dropped the team to just 1-3 on the season. The team has gone through radical changes after firing long-time head coach Mike Gundy after its loss two weeks ago and then dismissing defensive coordinator Tom Grantham after this defeat. Interim head coach Doug Meacham will have his hands full with a team that has now lost 12 straight games to FBS opponents.
It was a back-and-forth contest on Saturday, with both offenses excelling. Cowboys’ quarterback Zane Flores finished the day 23-of-41 for 232 yards. Running back Trent Howland ran for 87 yards and two touchdowns in the contest. Both numbers were career-highs for the back. In all, the Cowboys had 448 yards of total offense, including nearly 300 through the air. The 448 yards of total offense represent a season-high for Oklahoma State. The team performed some trickery as well, with wide receiver Sam Jackson completing a 26-yard touchdown pass to fellow wideout Josh Ford in the first quarter.
Defensively, the Cowboys struggled all afternoon to contain Baylor. The Cowboys’ defense allowed 612 yards of total offense, nearly 400 through the air and 212 on the ground. Bryan McCoy Jr. had eight tackles to lead Oklahoma State. The team allowed 29 first downs in the game, and Baylor averaged 8.3 yards per play.
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The Cowboys are 125th in the country in scoring. They are 48th in rushing and 96th in passing. In the red zone, the Cowboys rank 68th in the nation. They are 48th in sacks allowed this season. Oklahoma State is 133rd in points allowed per game. The team is 129th against the run and 127th against the pass. They are near the bottom in sacks per game, ranked 132nd in the country. The Cowboys are 74th in penalties per game and 60th in turnover margin.
Key Injuries: WR Da’Wan Lofton, TE Quinton Steward, and TE Oscar Hand are questionable. QB Hauss Hejay is out.
Arizona running wild
After a 3-0 start in nonconference play, the Arizona Wildcats were humbled at #14 Iowa State last Saturday night in their Big 12 opener, 39-14. The Wildcats fell behind 22-0 early and were never able to get back in the game. They now return home hoping to even their Big 12 record to 1-1 when they square off with Oklahoma State on Saturday afternoon.
“This is a much different team,” Head coach Brent Brennan said during his weekly news conference on Monday following Arizona’s 39-14 loss to No. 14 Iowa State in Ames. “I’m excited to see how we respond in practice (on Tuesday),” added Brennan, as the Wildcats prepare to host Oklahoma State for their Big 12 home opener. “That’s what I want to see.”
Quarterback Noah Fifita led the Arizona offense, completing 32-of-38 passes for 253 yards and two touchdowns. He also had two costly interceptions, his first two of the season. Running back Ismail Mahdi had 85 yards rushing on just 13 carries. Wide receiver Kris Hutson had six catches for 67 yards while teammate Chris Hunter added five catches for 59 yards. Arizona finished with 360 yards of total offense but went just 5-of-15 on third and fourth down conversions.
The Wildcats’ defense allowed the Cyclones 399 yards of total offense. They did limit the Iowa State ground game, holding them to just 111 rushing yards on 47 carries. Linebacker Dalton Johnson had a big night with 10 tackles to lead the team. Tredan Stukes had nine tackles and an interception. Linebacker Riley Wilson led the pass rush, earning two sacks on the night.
Arizona is ranked 73rd in the country in points per game. They are 24th in rushing the football and 93rd through the air. The Wildcats are ranked 49th in red zone offense. They are 48th in the nation in sacks allowed this season. Defensively, Arizona ranks 33rd in the country in points allowed per game. They are 14th against the run and 44th against the pass. The Wildcats are ranked 29th in red zone defense. The team is a solid 29th in the country in sacks per game. The Wildcats are 55th in penalties per game and 15th in turnover margin.
Key Injuries: WR Rex Hagas, TE Chase Randall, WR Landon Kelsey, RB Kendrick Reescano, and TE Kellen Ford are questionable. TE Tyler Powell is out.
Oklahoma State vs. Arizona Pick
Point Spread pick for Oklahoma State vs. ArizonaÂ
- Arizona -20.5 (4 units)
Oklahoma State is in complete disarray heading into this matchup on the road in Arizona on Saturday. The Cowboys have now fired the two highest-paid coaches on their staff, Gundy and the defensive coordinator, in the span of two weeks. That defense has been abysmal this season, ranking near the bottom in points allowed, run defense, and pass defense. They now get an Arizona team that is anxious to wipe away a disappointing loss on the road at Iowa State last week. The Wildcats should run wild over the porous Oklahoma State run defense. That ability to run at will should set up a passing attack that threw for over 250 yards last week. The Cowboys rank in the top 50 in the nation in rushing, but square off against an Arizona team that is 14th in the country in stopping the run. Given all that has gone on over the past few weeks, the Cowboys’ players can be forgiven if they already have their eyes on playing elsewhere next year as the AD sorts out this coaching staff. They won’t be ready for this one on Saturday.
Take Arizona -20.5
Over/Under Pick for Oklahoma State at ArizonaÂ
- Under 55.5Â
The majority of the scoring on Saturday will come from the Wildcats. They’ll have plenty of opportunities to cash in on Oklahoma State’s defense. On the other side of the ball, however, the Cowboys will struggle to put up points against an Arizona team that ranks 33rd in the country in points allowed this season. Arizona will build a lead and then pound Oklahoma State with the country’s 24th-best ground game. That will keep the clock moving and shorten this game.
Take the under.
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