Oklahoma State vs West Virginia Picks and Prediction for Saturday, September 26, 2026

The Oklahoma State Cowboys visit the West Virginia Mountaineers on Saturday at Milan Puskar Stadium in Morgantown, with the opening kickoff at 7:00 PM ET and televised on FS1. Oklahoma State is 2-1 overall and 0-0 in the Big 12 after beating Murray State 59-0. West Virginia is 3-0 overall and 0-0 in conference play after a 38-27 win over Virginia. The Mountaineers are among seven Big 12 teams without a conference loss, while the Cowboys have won two straight since dropping their opener. Let’s break down all the matchups with our free NCAAF picks.

Oklahoma State Cowboys Coming Off Two Straight Wins

Oklahoma State has responded to a 24-10 loss at Tulsa with a 39-31 win over Oregon and a 59-0 victory over Murray State. Drew Mestemaker has completed 75 of 114 passes for 882 yards, eight touchdowns, and four interceptions while averaging 7.7 yards per attempt. Justin Bowick leads the receiving corps with 281 yards and three touchdowns, while Wyatt Young has 218 yards and two scores. Caleb Hawkins leads the rushing attack with 261 yards and one touchdown on 52 attempts.

The Cowboys have produced 919 passing yards and 665 rushing yards, averaging 5.5 yards per carry. Mestemaker has also contributed 106 rushing yards and a touchdown. Oklahoma State has four sacks and two interceptions defensively, with Jaleel Johnson, Keviyan Huddleston and Malik Charles each recording one sack. Ethan Wesloski leads the Cowboys with 19 tackles, while Tate Romney has 17. The defense is coming off its first shutout of the season.

Injuries: C. Barnes (questionable), J. Sexton (questionable), O. Hammond (out).

West Virginia Mountaineers Unbeaten Through Three Games

West Virginia has opened with victories over Coastal Carolina, UT Martin and Virginia, scoring at least 31 points in each game. Michael Hawkins Jr. has completed 26 of 38 passes for 477 yards, five touchdowns and no interceptions while averaging 12.6 yards per attempt. Hawkins has been even more productive on the ground, rushing for 322 yards and six touchdowns. DJ Epps has 240 receiving yards and three touchdowns on only eight catches, averaging 30.0 yards per reception.

The Mountaineers have rushed for 844 yards and 10 touchdowns on 163 attempts, an average of 5.2 yards per carry. Cam Cook has added 317 yards and three touchdowns behind Hawkins. West Virginia’s defense has recorded 10 sacks and one interception. Ashton Woods has two sacks and the team’s interception, while Isaiah Patterson has 26 tackles and one sack. Geimere Latimer II has 16 tackles, one sack, and two forced fumbles.

Injuries: C. Ball (questionable), A. Devine (questionable), C. Talley (out).

Key to the Game

Oklahoma State’s ability to contain Hawkins could decide this matchup. West Virginia’s quarterback is averaging 12.6 yards per pass attempt and 7.3 yards per rush, creating explosive plays in two different ways. Oklahoma State has only four sacks, so keeping Hawkins in the pocket will be difficult without more pressure up front. The Cowboys can answer with Mestemaker and a passing attack featuring Bowick and Young, but his four interceptions create risk against a West Virginia defense that has already produced 10 sacks.

Oklahoma State vs West Virginia Game Pick

• Oklahoma State -1.5 (-110)

Oklahoma State -1.5 is the pick in a matchup where either offense can create chunk plays. The Cowboys have scored 98 points over their last two games, and Mestemaker has several productive receiving options alongside a ground attack averaging 5.5 yards per carry. West Virginia presents a major challenge with Hawkins accounting for 799 yards through the air and on the ground, but Oklahoma State’s offensive balance can keep the Cowboys productive if West Virginia slows one phase. The short spread makes Oklahoma State the play.

Oklahoma State vs West Virginia Over/Under Pick

• over 58.5 (-110)

The play is over 58.5. West Virginia has scored 31, 52 and 38 points, while Oklahoma State has put up 39 and 59 in its last two games. The Mountaineers have averaged 5.2 yards per rush and 12.3 yards per pass attempt as a team, while the Cowboys are averaging 5.5 yards per carry with nine passing touchdowns. Hawkins’ rushing ability adds another scoring threat near the goal line, and both offenses have multiple players capable of creating long gains.