Ole Miss at Oklahoma Picks and Prediction, Saturday, October 25, 2025
Use Code WWWC It’s a massive SEC clash on Saturday, Oct. 25. Read our Ole Miss vs Oklahoma prediction along with our other NCAAF Betting Picks! Ole Miss is 6-1 and they are the No. 8 team in the nation. The Rebels lost their first game of the season last week to Georgia after winning six straight. The Sooners are also 6-1, and they come into this game ranked No. 13. Oklahoma earned a big win over South Carolina last week. These two teams will meet with the kick-off set for 12 P.M. EST.
Ole Miss looking for bounce-back win
Ole Miss is 6-1 overall and they are 3-1 in the SEC. The Rebels are in fourth place in the SEC as they are behind Alabama and Texas A&M, who are undefeated in league play. Ole Miss started the season winning six straight games with a key win over LSU. The Rebels have four wins separated by one possession.
In their last game, Ole Miss lost 43-35 on the road to Georgia on Saturday, Oct. 18. Ole Miss led for a majority of the first half as they led 21-20 at the break. At the end of the third quarter, Ole Miss 35-26, but momentum swung in the Bulldogs’ favor in the final period. Georgia scored 17 unanswered points.
Quarterback Trinidad Chambliss threw for 263 yards and one touchdown on 19-for-36 passing. He also led the offense with 42 yards and two touchdowns on nine carries. Wide receiver De’Zhaun Stribling threw for 96 yards on three catches and a touchdown.
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Chambliss has thrown for 1,549 yards and has completed 63% of his passes. He’s tossed eight touchdowns and a pick this season. Kewan Lacy has been dominant with 618 rushing yards and 10 touchdowns.
“Basically, hardly anybody’s done anything against them,” Ole Miss head coach Lane Kiffin said about Oklahoma’s defense. “I think they’ve given up five or six touchdowns all year long. They’re just really sound.”
Ole Miss’ defense is led by linebacker TJ Dottery with 46 tackles. Two different players lead the team with three sacks each. The defense has forced four turnovers, also.
Ole Miss is averaging 37.4 points per game, which ranks 16th best in the nation. The Rebels are averaging 304 passing yards per game, placing them eighth-best. They also rank 42nd in rushing yards per game, going for 187 yards per game.
On defense, Ole Miss is allowing 22.6 points per gam,e which ranks 55th. They are allowing 195.6 passing yards per game, which places them 38th. They rank 100th in defending the rush, allowing 166.7 yards per game.
Ole Miss is 4-3 against the spread this season. The Rebels are 0-2 against the spread when they have played on the road. Ole Miss is 0-1 against the spread when they have been underdogs. They are 2-2 against the spread when playing SEC opponents. The over is 4-3 when Ole Miss has played. The over is 2-0 when playing on the road. The total is 2-2 when the total has been set at 59 points or less.
Oklahoma’s defense continues to be elite
Oklahoma is 6-1 overall and they have a 2-1 SEC record. The Sooners are tied for 5th place in the conference as they are the No. 13-ranked team in the nation. The Sooners bounced back last week with a key win after their 23-6 loss to Texas.
In their last game, Oklahoma defeated South Carolina 26-7 on the road on Saturday, Oct. 18. In their six wins, Oklahoma hasn’t allowed more than 17 points. Oklahoma never trailed in their win over South Carolina. Quarterback John Mateer threw for 150 yards on 18-for-26 passing and a touchdown. Running back Tory Blaylock rushed for 101 yards on 19 carries and a score, too. The defense forced two turnovers in the win as South Carolina went 3-for-15 on third down.
Mateer has returned from his injury a few weeks ago and has been solid. He’s thrown for 1,567 yards and has completed 65% of his passes. He’s thrown seven touchdowns and six picks. He’s also rushed for 209 yards and a team-high five touchdowns. Blaylock has rushed for a total of 391 yards and five scores, too. Wide receiver Isaiah Sategna III has been Oklahoma’s go-to target. He’s caught a team-high 493 yards and four touchdowns.
“They've got an excellent roster, an elite staff, a staff that's won at the highest level, and they're playing really, really well,” Oklahoma head coach Brent Venables said. “Obviously, the head coach being an offensive guy, they're kind of headlined offensively and justifiably so.”
On defense, Oklahoma has been fantastic as one of the top teams in the country. Leading the team in tackles is Kip Lewis with 31 total tackles. Nine different players have over 20 tackles. R Mason Thomas has a team-high 5.5 sacks, too. The defense has only forced four turnovers on the season.
Oklahoma is averaging 29.2 points per game, which ranks 68th in the nation. They are the 39th-ranked passing offense, averaging 266.7 yards per game. The Sooners are averaging 122.3 yards per game on the ground, which ranks 108th.
On defense, Oklahoma is allowing 9.8 points per game, which is the second-best mark in the country. They are the second-best passing defense, allowing 126.3 yards per game. The Sooners are the sixth-best rush defense, giving up 84.8 yards per game on the ground.
Oklahoma is 3-3-1 against the spread this season. The Sooners are 1-2-1 against the spread when they have played at home. They are 3-2-1 against the spread when they have been favored. The under is 7-0 when Oklahoma has played this season.
Ole Miss Rebels vs Oklahoma Sooners Picks
Ole Miss vs Oklahoma Spread Pick
- Ole Miss +5.5 (5 units)
It’s one of the games of the week in college football as No. 8 Ole Miss travels to No. 13 Oklahoma. This is a big resume' builder for both teams when seeding for the College Football Playoff comes around. It’s all going to be decided when Ole Miss is on offense and Oklahoma is on defense. Both teams are elite on those two sides of the ball. Oklahoma’s defense hasn’t allowed more than 17 points in a win this year. Ole Miss does have the firepower to score points quickly thanks to quarterback Trinidad Chambliss and running back Kewan Lacy. Ole Miss had Georgia on the ropes in their last game before faltering in the fourth quarter. Ole Miss really only needs to put between 21-28 points to walk away victorious because of Oklahoma’s poor offense.
The Sooners rank 68th in scoring, while quarterback John Mateer has returned from his injury, he hasn’t looked the same as he did in the opening few weeks. Ole Miss can load the box and force some long third downs as they rank 38th in pass defense.
Take Ole Miss to cover.
Ole Miss vs Oklahoma Over/Under Pick
- Under 53.5 (5 units)
Oklahoma’s defense is elite and will force quite a few stops. Ole Miss’ defense is underrated and going against an Oklahoma offense can struggle at times. This is set for a low-scoring game, especially between two defenses that do not force turnovers. Extra possessions will not be happening much, and solid punts will back each other into opposing territory, needing long drives to score points. This is going to be low low-scoring affair simply because of those factors. The under has hit in every Oklahoma game this season and I don’t see it straying from there this week.
Take the under on Saturday.
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