Ole Miss vs Oklahoma Picks and Predictions for Saturday, November 14, 2026

The 19th-ranked Ole Miss Rebels visit Oklahoma on Saturday at Memorial Stadium in Norman. Ole Miss is 6-3 and sixth in the SEC at 4-3 after a 42-7 home loss to top-ranked Georgia. Oklahoma is 5-4, tenth in the conference at 3-3, following a 23-7 win over Florida. The Rebels have split their last four games, while the Sooners have alternated wins and losses. Kickoff is 4:15 pm ET on SEC Network, with temperatures around 63 degrees. Ole Miss is favored by 1.5 points, and the total is 48.5. See our free college football picks for more Saturday matchups.

Ole Miss Looking for a Response

Georgia handed Ole Miss a difficult afternoon last Saturday. The Rebels scored just seven points and allowed 42 in a heavy home defeat. It was a sharp change from the previous week, when Ole Miss routed Auburn 45-15. The Rebels have been hard to predict lately, beating Missouri 31-3 and Vanderbilt 52-17 but losing 34-27 at Texas. Their offense has shown it can produce big numbers, although Georgia shut it down completely. Oklahoma's defense presents another demanding matchup.

Trinidad Chambliss has thrown for 2,359 yards, 18 touchdowns and nine interceptions, completing 62.7% of his passes. He has also rushed for 187 yards and seven scores. Kewan Lacy leads the running backs with 388 yards and five touchdowns, while Makhi Frazier adds 365 yards. Deuce Alexander has caught 48 passes for 669 yards and five touchdowns. Horatio Fields contributes 453 receiving yards. Defensively, Blake Purchase has 4.5 sacks, and Keaton Thomas leads Ole Miss with 55 tackles. Protecting Chambliss is essential against Oklahoma.

Injuries: Ole Miss has no injuries listed.

Oklahoma Coming Off a Strong Road Win

Oklahoma traveled to Florida last Saturday and came away with a 23-7 victory. The Sooners needed that defensive response after surrendering 42 points in a 42-25 home loss to South Carolina. Oklahoma has won three of its last five games, also beating Mississippi State 23-15 and Texas 27-24. The defense has held three of those five opponents to 15 points or fewer. Scoring remains less consistent for the Sooners, who haven't reached 30 points in their last five outings.

John Mateer has passed for 2,042 yards, 15 touchdowns and seven interceptions, completing 65.4% of his attempts. Isaiah Sategna III leads Oklahoma with 625 receiving yards and four touchdowns, while tight end Rocky Beers has 518 yards and four scores. Lloyd Avant leads the ground game with 394 yards, but the Sooners average only 3.2 yards per rush. Owen Heinecke has a team-high 73 tackles, and Peyton Bowen has three interceptions. Oklahoma needs those defensive playmakers against Ole Miss.

Injuries: E. Thomas is questionable. T. Harris is out.

Key To The Game

Oklahoma's defense just limited Florida to seven points, while Ole Miss managed only seven against Georgia. Chambliss must avoid mistakes against a Sooners secondary with nine interceptions. Oklahoma's rushing game averages 3.2 yards per carry, so Mateer may have to carry much of the offensive load.

Ole Miss vs Oklahoma Game Pick

• Oklahoma Sooners +1.5

Ole Miss has the more productive rushing attack, but its seven-point performance against Georgia raises questions heading into Norman. Oklahoma is coming off a convincing win at Florida and has held three of its last five opponents to 15 points or fewer. Mateer can find Sategna and Beers if the running game stalls, while Bowen gives the Sooners a chance to exploit Chambliss' nine interceptions. Oklahoma hasn't been consistent offensively, but home field and its recent defensive form make the difference. I'll take the Sooners with the points.

Ole Miss vs Oklahoma Over/Under Pick

• Under 48.5

Both teams scored just seven points in one of their last two games, and Oklahoma has played several low-scoring contests recently. The Sooners average only 3.2 yards per rush, making sustained drives harder to produce. Ole Miss can hit big plays through Chambliss and Alexander, but Georgia showed how difficult things get when the Rebels can't establish a rhythm. Oklahoma's defense has held Florida, Mississippi State and Kentucky to 15 points or fewer. A close game with limited rushing room points toward under 48.5.