Oregon Ducks vs. Penn State Nittany Lions Picks and Prediction, Saturday, September 27, 2025
Use Code WWWC In this Oregon at Penn State prediction, two National powers will do battle at Beaver Stadium in University Park, PA. The Ducks and Nittany Lions are both undefeated, with Oregon ranked #6 in the country and Penn State ranked third. The winner of this Big Ten clash could have the inside track to get to the Big Ten Title game later this fall. The opening kick is scheduled for 8:00 pm EST. Don’t get sacked this football season! Try our College Football Picks!
Oregon with a huge road testÂ
The Oregon Ducks arrive in Happy Valley with a perfect 4-0 mark after taking care of in-state rival Oregon State 41-7 last week in Oregon. The win was the 37th straight at home for the Ducks, the top current streak in the country. They’ll now hit the road for a huge tilt against Penn State, hoping to stay perfect overall and perfect in the Big Ten.
"We've got to be cleaner in some of our issues there, from a penalty standpoint, just our operation overall," said UO coach Dan Lanning about his team’s performance against the Beavers. "But ultimately a dominant performance, and really a challenge for us heading into this next week as we go to Penn State."
Quarterback Dante Moore continued his fabulous start to the season in the one-sided victory. Moore went 21-of-31 for 305 yards and four touchdowns. He threw his touchdowns to four different receivers. In all, the Ducks finished with a whopping 585 yards of total offense. They finished with 29 first downs and averaged 7.6 yards per play. The Ducks were 4-for-4 in the red zone and went 4-of-12 on third down conversions. Oregon didn’t turn the ball over and held the ball for 36:55.
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Defensively, after allowing Oregon State to score on its first drive and produce 76 yards in the first quarter, the Ducks' defense tightened up. They allowed just 71 yards over the final three quarters. Bryce Boettcher led the way with ten tackles, including nine in the first half. The Ducks held Oregon State to just eight first downs in the entire game. The team finished with four tackles for loss.
The Oregon Ducks are sixth in the country in points per game this season. The Ducks are sixth in rushing offense and 29th in passing offense. They are tied for the top spot in red zone offense. The Ducks are third in the nation in sacks allowed per game. On the defensive end, the team is third in points allowed per game. The Ducks are 49th against the run and an impressive second against the pass. The Ducks are just 106th in the nation in red zone defense. They are also just 91st in sacks per game. Oregon is 14th in turnover margin, 13th in penalties per game, and 46th in time of possession.
Key Injuries: WR Jurrion Dickey is out. WR Dillon Gresham, OL Alex Harkey, WR Justius Lowe, QB Austin Novosad, LB Bradyen Platt, and WR Jack Ressler are questionable.
Nittany Lions looking to be the top dog
The Penn State Nittany Lions return from a bye week with a perfect 3-0 mark, including a 52-6 win over Villanova in their last outing. This will mark the fourth straight home game for the Nittany Lions, with the team looking to take hold of the top spot in the Big Ten Conference.
"You look at the game, the one turnover, that one drives me crazy, because although it wasn't as clean as I'd like it to be, and I think we make it harder than it needs to be at times, I do think we're playing winning football. On that one, we had a missed assignment, and you can't let one bad thing turn into two bad things. Overall, I've been pleased with how we're playing. We won the turnover battle. We won the explosive play battle. We won the third down battle. We won the sack battle. We won the field position battle. We won the penalty battle, and we won the middle eight. All those things are positives that we’ve got to build on." head coach James Franklin said after the game.
Penn State had a balanced attack against Villanova, finishing with 237 yards passing and 228 yards rushing. Quarterback Drew Allar completed 16-of-29 passes for 209 yards and a touchdown. Tight end Luke Reynolds led the team with 73 yards receiving on just four catches for an average of 18.3 yards per catch. The Nittany Lions’ ground game was led by running backs Nicholas Singleton and Kaytron Allen. Allen finished with 86 yards rushing on 10 carries with a touchdown. Singleton had 84 yards and two touchdowns. In total, the Nittany Lions had 465 yards of total offense and turned the ball over once.
The Penn State defense kept Villanova in check, holding the Wildcats to just 179 yards of total offense. That includes just 96 yards passing. Linebacker Amare Campbell had a big day with seven tackles and a sack. Fellow linebacker Tony Rojas finished with two sacks and five tackles in the winning effort. Safety Dejuan Lane had five tackles in total. Cornerbacks Elliot Washington II and Jahmir Joseph each had an interception in the game, with Joseph returning his pick for a 49-yard touchdown.
The Nittany Lions are ranked 18th in the nation in scoring offense. They are 29th in rushing and 41st through the air. Penn State ranks first in red zone offense, and the team is 50th in sacks allowed. Defensively, they are first in the country in points allowed per game. The Nittany Lions are 32nd against the run and eighth against the pass. The team is second in red zone defense. The Nittany Lions are 33rd in sacks per game. The team ranks third in turnover margin, fourth in penalties per game, and 71st in time of possession.
Key Injuries: WR Josiah Brown and WR Kaden Saunders are out. WR Peter Gonzalez and QB Bekkem Kritza are questionable.
Oregon vs. Penn State PickÂ
Point Spread pick for Oregon vs. Penn State
- Penn State -1.5 (4 units)
Two great teams square off at Beaver Stadium on Saturday night. The key to the game will be Penn State’s ability to shut down the highly potent Ducks’ offense. The best way to attack the Ducks and limit their scoring will be to control the football. This will be a game that should feature a run-heavy attack from the Nittany Lions. The team is ranked 29th in the country in rushing offense and has arguably the best running back combo in the country this season in Allen and Singleton. Penn State does two things extremely well: protect the football and limit penalties. That should set the team up for long drives. The Nittany Lions are third in the country in turnover margin and fourth in fewest penalties per game. The Ducks won’t be stopped, but can be had if the Nittany Lions can limit their opportunities. The Nittany Lions can control the tempo, pound the ball on the ground, and limit the Ducks in the red zone. Penn State is second in the country in red zone defense. They’ll deliver at home on Saturday with a week to prepare for Oregon.
Take Penn State -3.5
Over/Under Pick for Oregon vs. Penn StateÂ
- Over 52.5Â
Hard to imagine that either of these two dynamic offenses will be truly stopped on Saturday night. Both teams are ranked in the top 20 in the country in scoring offense. Both teams are dynamic in the red zone, and both are very efficient. The game will ultimately be decided by which team can hold the other to field goals instead of touchdowns. Still, even with that, this game should feature plenty of high-powered offense.
Take the over.
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