Oregon vs Oklahoma State Picks and Prediction for Saturday, September 12, 2026

No. 2 Oregon visits Oklahoma State on Saturday at Boone Pickens Stadium in Stillwater, with the opening kickoff at 12:00 PM ET and televised on ESPN. Oregon is 1-0 after a 34-27 win over Boise State, while Oklahoma State is 0-1 following a 24-10 loss at Tulsa. The Ducks are 22.5-point favorites after opening at -20.5, while the total is 59.5. Build your bankroll with our free NCAAF picks.

Oregon Coming Off a Close Opening Win

Oregon gained 497 total yards in its 34-27 victory over Boise State, led by a strong performance from Dante Moore. The quarterback completed 28 of 37 passes for 378 yards and three touchdowns without an interception, averaging 10.2 yards per attempt. Jordon Davison led the rushing attack with 90 yards and a touchdown on 12 carries, including a 40-yard run. The Ducks finished with 119 rushing yards and averaged 4.8 yards per attempt.

Jeremiah McClellan caught six passes for 150 yards and a touchdown, while Dakorien Moore added six receptions for 93 yards and the decisive 62-yard score in the fourth quarter. Evan Stewart caught eight passes for 72 yards, and Jamari Johnson added 57 yards and a touchdown. Oregon's defense recorded three sacks, with Matayo Uiagalelei, Bear Alexander and Teitum Tuioti each recording one. Koi Perich led the Ducks with 11 tackles.

Injuries: Wide receivers Jalen Lott and Iverson Hooks are questionable with undisclosed injuries.

Oklahoma State Searching for More Offense

Oklahoma State opened with a 24-10 road loss to Tulsa despite gaining 368 total yards and recording 27 first downs. Drew Mestemaker completed 29 of 49 passes for 241 yards, one touchdown and two interceptions. The Cowboys rushed for 127 yards on 37 attempts, averaging 3.4 yards per carry without a touchdown. Caleb Hawkins led Oklahoma State with 79 yards on 18 carries, while Ayo Adeyi added 24 yards on six attempts.

Wyatt Young was the leading receiver with eight catches for 84 yards, while Justin Bowick caught the Cowboys' only touchdown pass. Oklahoma State converted 5 of 16 third downs and 2 of 6 fourth downs against Tulsa while committing four turnovers. Defensively, the Cowboys did not record a sack. Ethan Wesloski and Tate Romney each finished with seven tackles, while LaDainian Fields recorded Oklahoma State's only interception.

Injuries: Tight ends Oscar Hammond and Donovan Green are questionable with undisclosed injuries. Offensive lineman Jacob Sexton is questionable with a leg injury.

Key to the Game

Oregon's passing attack against Oklahoma State's defense is the matchup to watch. Dante Moore completed 75.7 percent of his passes and produced 378 yards with three touchdowns against Boise State. Oregon also had four players record at least 57 receiving yards. Oklahoma State failed to record a sack against Tulsa, making pressure on Moore a major concern. If the Cowboys cannot disrupt the Oregon quarterback, McClellan, Dakorien Moore and the rest of the Ducks' receiving group could produce another productive afternoon.

Oregon vs Oklahoma State Game Pick

• Oregon -22.5

Oregon is the pick after producing 497 yards against Boise State while Dante Moore threw for 378 yards and three touchdowns without an interception. Oklahoma State allowed 24 points to Tulsa and failed to record a sack, which could become a larger problem against Oregon's passing attack. The Cowboys also committed four turnovers in their opener, including two Drew Mestemaker interceptions. Oregon has several receiving threats and a productive rushing option in Jordon Davison, putting the Ducks in position to create a big lead and cover the spread.

Oregon vs Oklahoma State Over/Under Pick

• Under 59.5

Under 59.5 is the pick with Oklahoma State coming off a game in which the Cowboys scored only 10 points despite recording 27 first downs and 368 total yards. Four turnovers hurt Oklahoma State, while the offense averaged only 3.4 yards per rush. Oregon scored 34 against Boise State, but the Ducks also committed 10 penalties and needed a fourth-quarter touchdown to finish the win. Oregon can score enough to control this matchup without Oklahoma State producing enough points to push the combined score over.