South Florida (USF) vs Florida Picks and Prediction for Saturday, September 6, 2025
On Saturday, the South Florida Bulls (1-0) visit Gainesville, Florida, and Ben Hill Griffin Stadium to play the #13-ranked Florida Gators (1-0). South Florida opened its season with a convincing 34-7 victory over the Boise State Broncos. Florida shut out Long Island University 55-0 in its season opener. South Florida does not have any players listed on its injury report. Florida will play without WR Kahleil Jackson, while the Gators have nine players listed as questionable. Make sure to read this in-depth South Florida Bulls vs Florida Gators prediction. Buckle up! Dive into our top NCAAF picks for South Florida (USF) Bulls vs. Florida Gators prediction and dominate your wagers.
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South Florida took care of business on both sides of the line of scrimmage
The South Florida Bulls looked strong both on offense and defense in their opening game upset of Boise State. South Florida scored 34 points, with 117 yards rushing and 255 yards passing for 372 yards of total offense. The Bulls’ defense gave up just seven points on 122 yards rushing and 256 yards passing for 378 yards.
South Florida quarterback Byrum Brown has thrown for 210 yards. The only passing touchdown for the Bulls was by backup Locklan Hewlett. Alvon Isaac has 52 yards rushing to lead the Bulls, while Brown has 43 yards rushing and two touchdowns. Chas Nimrod has 96 yards receiving to lead South Florida, while Keshaun Singleton has 93 yards receiving and one touchdown reception. On defense, linebacker Jhalyn Shuler leads South Florida with 14 tackles. South Florida has made one sack but has not intercepted a pass.
Florida's offense looked very strong, while its defense was exceptional
The Florida Gators scored 55 points in their first game of the season. Florida had 200 yards rushing and 251 yards passing for 451 yards of total offense. The Florida defense shut out Long Island University, allowing 37 yards rushing and 49 yards passing for a total of just 86 yards.
Florida starting quarterback DJ Lagway has 120 yards passing with three touchdowns, while the back of Trammel Jones Jr has 131 yards passing and two touchdowns. Jadan Baugh leads Florida in rushing with 104 yards and one touchdown, and Vernell Brown III is the leading receiver with 79 yards. Florida has scored one touchdown on the ground and five through the air. On defense, linebacker Myles Graham and Edge rusher Kamran James lead Florida in tackles with five each. Florida’s defense did not make any sacks or intercept any passes.
South Florida vs. Florida Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vinciletti | +1,570.00 |
| 2 |  Dan Kaiser | +1,223.00 |
| 3 |  Ross Benjamin | +1,000.00 |
| 4 |  Earle Sports Bets | +916.00 |
| 5 |  David Hess | +706.00 |
Spread Pick for South Florida vs. Florida
- Florida Gators (4 units)
The Florida Gators looked very strong both on offense and defense in their 55-0 victory over Long Island University in the first game of the season. QB DJ Lagway saw limited action under center for Florida in the rout, but threw three touchdown passes. Florida's defense held the Sharks to just 86 yards of total offense. The Florida offense had 200 yards rushing, led by Jadan Baugh with 104 yards in limited action. South Florida looked strong in its season opener when upsetting Boise State, but the Bulls must play in “The Swamp” and face a Florida defense that is far superior to that of the Broncos. South Florida gained 255 yards passing in its victory over Boise State, but faces a Florida defense that gave up just 49 yards passing to Long Island. Florida starting quarterback DJ Lagway is now 7-1 as a starter for the Gators.
Over/Under Pick for South Florida vs. Florid
- Over (4 units)
Full game total prediction analysis The Florida Gators will score plenty of points against the South Florida Bulls, and South Florida’s offense will score at least a pair of touchdowns against Florida. Florida put 55 points up on the board against Long Island University. South Florida scored 34 points in its opening game versus a solid Boise State defense.
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