Syracuse Orange vs Notre Dame Fighting Irish Prediction and Picks - November 22, 2025
Use Code WWWC College football action on Saturday evening, and we have a Syracuse vs Notre Dame Prediction ready to rock and roll. The Orange come into this contest off a 38-10 loss at Miami to fall to 3-7 on the year. Notre Dame comes in off a 37-15 home win over which puts them at 8-2 on the season. They have now won 8 in a row and will be looking to stay in the race for a playoff spot. Notre Dame has won the last five games in this series. Continue reading to see our Syracuse vs Notre Dame prediction.
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Syracuse Gets Blown Away By The Hurricanes
Syracuse walked off the field in Miami with a 38‑10 loss that highlighted the team’s ongoing struggles. Quarterback Rickie Collins never found a rhythm, throwing for just 85 yards and two interceptions, while freshman Joe Filardi came in late to engineer the lone touchdown drive capped by a 17‑yard strike to Elijah Washington‑Baker. Running back Yasin Willis provided some spark with 63 rushing yards, but the Orange were outgained 385‑285 and turned the ball over three times, continuing a season‑long theme of mistakes that have cost them winnable games.
Collins has been inconsistent after taking over for Angeli, completing just over 53% of his passes for 1,042 yards with six touchdowns against 10 interceptions. Willis has been the most dependable option in the backfield, rushing for 563 yards and four scores, while receivers Donovan Gill Jr. (477 yards, 5 TDs) and Joshua Cook (518 yards, 2 TDs) have been the primary playmakers in the passing game. Despite flashes of explosiveness, Syracuse averages only 22.3 points per game, ranking 108th nationally, and their 20 turnovers have been a major obstacle to sustaining drives and keeping games competitive.
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Defensively, the Orange have been unable to slow opponents, giving up 430.6 yards per game and 31.5 points per contest. The secondary has been particularly vulnerable, surrendering 267.1 passing yards per game, while the run defense has been middling at 163.5 yards allowed. With only five takeaways all season, Syracuse rarely flips momentum in its favor, leaving the offense to play from behind far too often. Heading into South Bend, the Orange will need Collins or Filardi to protect the football and hope their defense can hold up against one of the nation’s most balanced and explosive attacks.
Irish Looking To Stay In The Playoff Picture
Notre Dame enters this matchup riding high after a 37‑15 win at Pittsburgh, a game that showcased their balance on both sides of the ball. Freshman quarterback CJ Carr threw for 212 yards and two touchdowns while also adding a rushing score, continuing to look comfortable in command of the offense. Running back Jeremiyah Love was the star once again, rushing for 147 yards and a touchdown, while wideout Malachi Fields hauled in two scores. The Irish defense forced two turnovers, including a pick‑six, and shut down Pitt’s running game to extend their winning streak to eight.
Carr has been the centerpiece of the offense all season, completing 67.3% of his passes for 2,487 yards and 21 touchdowns. Love has emerged as one of the nation’s premier backs, piling up 1,135 yards and 14 touchdowns at 6.4 yards per carry, giving Notre Dame a reliable weapon to lean on in any situation. The receiving corps is deep and versatile, with Fields (596 yards, 5 TDs), Jaden Faison (551 yards, 3 TDs), and Will Pauling (367 yards, 5 TDs) all capable of stretching defenses. With an average of 38.5 points per game, ranking eighth nationally, the Irish have consistently overwhelmed opponents with their ability to attack through the air and on the ground.
Defensively, Notre Dame has been just as impressive, allowing only 323.3 yards per game and 18.4 points per contest. Their run defense is elite, ranking 13th nationally at 99.3 yards allowed per game, while the secondary has held opponents to 224 passing yards. With 17 takeaways, the Irish have consistently created short fields for their offense, turning defense into offense in a way few teams can match. In the College Football Playoff picture, Notre Dame’s eight‑game winning streak has vaulted them into the top 10, sitting at No. 9 in the CFP rankings. That slot currently projects them into a first‑round matchup against No. 8 Oklahoma, with the winner advancing to face No. 1 Ohio State. While the Irish carry two losses, both came against ranked opponents (Miami and Texas A&M), and their dominant play since Week 3 has kept them firmly in contention. With Syracuse and Stanford left on the schedule, Notre Dame controls its path to lock down a postseason berth and potentially climb even higher before Selection Sunday.
Syracuse vs Notre Dame Pick
Syracuse vs Notre Dame Spread Pick
- Notre Dame -36 (2 Units)
Notre Dame -36 makes sense because the Irish have every reason to deliver a statement win. Sitting at No. 9 in the College Football Playoff rankings, they need style points to strengthen their case for a higher seed in the expanded bracket. CJ Carr has been sharp all season with over 2,400 passing yards and 21 touchdowns, while Jeremiyah Love has rushed for more than 1,100 yards and 14 scores. With a balanced offense averaging 38.5 points per game, Notre Dame has consistently overwhelmed opponents, and Syracuse’s defense—allowing 31.5 points per game and ranking near the bottom nationally in yards allowed—looks like a mismatch.
The Irish defense adds another layer of confidence to laying the big number. Ranked 17th nationally in scoring defense at 18.4 points per game, they’ve been dominant against the run and opportunistic with 17 takeaways. Syracuse, meanwhile, has been plagued by turnovers (20 on the season) and an offense averaging just 22.3 points per game. That combination sets up perfectly for Notre Dame to control the game from start to finish, forcing mistakes and capitalizing with short fields. With playoff positioning on the line and Senior Day energy in South Bend, the Irish have both the motivation and the firepower to cover a spread this large.
Syracuse vs Notre Dame Over/Under Pick
- Over 50.5 (1 Unit)
The Over 50.5 feels live because Notre Dame’s offense has been rolling at 38.5 points per game, and Syracuse’s defense has been one of the weakest in the ACC, giving up 31.5 points per game and over 430 yards. CJ Carr and Jeremiyah Love give the Irish a balanced attack that can score quickly, while Syracuse has enough playmakers in Donovan Gill Jr. and Joshua Cook to at least chip in points even if the game gets out of hand. With Notre Dame needing style points for the playoff picture and Syracuse’s defense unable to slow explosive teams, this matchup sets up for a total that clears the number.
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