Tulane Green Wave vs. Ole Miss Rebels Prediction and Picks - September 20, 2025
Use Code WWWC Saturday afternoon college football action, and we have a Tulane vs Ole Miss Prediction ready to rock and roll for you. The Green Wave enters this game at a perfect 3-0 on the year, and last week they topped Duke at home by a score of 34-27. Ole Miss is also at 3-0 on the year after topping Arkansas at home last week by a 41-35 score. These teams last met back in 2023 and Ole Miss won that game 37-20 on the road. Which team will remain perfect after this one? Read on to see our Tulane vs Ole Miss prediction.
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Green Wave Off To A 3-0 Start
Tulane enters Oxford at 3–0 and is quietly building a résumé that could earn them serious Group of Five playoff consideration. The Green Wave have already knocked off two Power Four opponents—Northwestern and Duke—and showed resilience in a 33–31 road win over South Alabama, rallying from a 14-point deficit. Quarterback Jake Retzlaff, a late transfer from BYU, has been a revelation. He rushed for 111 yards and four touchdowns last week against Duke and added 245 passing yards on just 23 attempts. His dual-threat ability has transformed Tulane’s offense, which now ranks top-25 nationally in rushing and averages 30 points per game. Shazz Preston has emerged as a legitimate deep threat, averaging over 30 yards per catch, and Arnold Barnes III adds balance in the backfield.
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Defensively, Tulane has been solid but not elite. They’re allowing 370 yards per game and rank 91st nationally in total defense, with particular vulnerability against the pass—235 yards per game allowed and a 59.5% completion rate. The run defense has been more stable, giving up 135 yards per game and 4.4 yards per carry. Javion White has been a standout in the secondary, tied for the national lead in interceptions, but the unit as a whole has struggled to contain explosive plays. Tulane’s strength lies in its offensive versatility and ability to control tempo, but they’ll need to tighten up defensively to keep pace with Ole Miss’s high-octane attack.
This is a statement opportunity for head coach Jon Sumrall, who’s already led Tulane to 39 wins in four seasons. The Green Wave were competitive in last year’s meeting before fading late, and they’ll need a fast start and mistake-free execution to flip the script. Retzlaff’s mobility and Tulane’s ability to sustain drives give them a path to scoring, but they’ll need to win the turnover battle and limit Ole Miss’s vertical game to stay within striking distance.
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Ole Miss Squeaks by Arkansas
Ole Miss enters at 3–0 and ranked No. 11 nationally, riding a wave of offensive momentum after a 41–35 win over Arkansas. Quarterback Trinidad Chambliss stepped in for the injured Austin Simmons and delivered a monster performance—353 passing yards on 72.4% completions, plus 62 rushing yards and two touchdowns on the ground. Simmons is expected to return this week, but either quarterback gives Lane Kiffin a dynamic option behind center. The Rebels rank 11th nationally in total offense (541.7 yards per game) and 14th in scoring (44.7 points per game), with a balanced attack that features Kewan Lacy in the backfield and Harrison Wallace III stretching defenses vertically.
Defensively, Ole Miss has been inconsistent. They’re allowing 21.7 points per game but rank 117th in rushing defense, giving up 194.7 yards per contest and 6.0 yards per carry last week to Arkansas. The secondary has held up better, allowing just 187 passing yards per game, but they’ve struggled to generate pressure and rank outside the top 70 in havoc rate. That’s a concern against a Tulane offense that thrives on misdirection and quarterback mobility. Ole Miss will need to shore up its tackling and stay disciplined in the second level to avoid giving up chunk plays on broken contain.
This is a dangerous spot for the Rebels. Tulane is receiving votes in both polls and has the kind of offensive identity that can frustrate Ole Miss’s defensive structure. Still, the Rebels have the talent edge and the home-field advantage, and if Simmons is fully healthy, they’ll have the firepower to pull away. Expect Lane Kiffin to lean on tempo and vertical shots early to test Tulane’s secondary, and if the defense can force Retzlaff into obvious passing downs, Ole Miss should be able to control the game script.
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Tulane vs Ole Miss Pick
Tulane vs Ole Miss Moneyline Pick
- Tulane +13 (4 Units)
Tulane +13 is a sharp spot, especially given the scheduling dynamics and historical trends working against Ole Miss. The Rebels are coming off a high-scoring win over Arkansas and have LSU on deck—a classic sandwich scenario that often leads to flat performances and conservative game plans. Tulane, meanwhile, is 3–0 and has already knocked off two Power Four teams, showing resilience and offensive versatility behind Jake Retzlaff’s dual-threat playmaking. The Green Wave rallied from 14 down to beat South Alabama and have covered twice this season, while Ole Miss is just 1–7 ATS in Game 4 over the past eight years—a trend that reflects Lane Kiffin’s tendency to throttle down in non-marquee spots.
This matchup also favors Tulane stylistically. Ole Miss ranks 117th in rushing defense and just gave up 194.7 yards on the ground to Arkansas, while Tulane ranks top-25 nationally in rushing offense and has a quarterback who just ran for four touchdowns against Duke. Retzlaff’s mobility and Tulane’s ability to control tempo could frustrate a Rebels defense that’s struggled to generate pressure and contain explosive plays. If the Green Wave can avoid early turnovers and force Ole Miss into longer drives, they have a clear path to keeping this game within single digits. With the Rebels likely rotating quarterbacks and managing reps ahead of LSU, Tulane is well-positioned to sneak inside the number.
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Tulane vs Ole Miss Over/Under Pick
- Under 61 (5 Units)
Under 61 makes sense in a matchup where both teams lean run-heavy and Ole Miss may throttle down in a sandwich spot. Tulane ranks top-25 in rushing offense and will look to control tempo behind Jake Retzlaff’s mobility, while Ole Miss has struggled to stop the run—ranking 117th nationally—but has also shown a tendency to slow games down when favored by double digits. With LSU looming and Austin Simmons nursing an ankle injury, Lane Kiffin may opt for a more conservative script, especially if the Rebels build a lead. Tulane’s defense isn’t elite, but they’ve held opponents to just 20.3 points per game, and their ability to limit possessions could keep this total in check.
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