UConn Huskies vs Buffalo Bulls Picks and Prediction for Saturday, September 27, 2025
Use Code WWWC The UConn Huskies (2-2, Indep) pay a visit to Buffalo and UB Stadium on Saturday to play the Buffalo Bulls (2-2, 1-0 MAC). UConn defeated Ball State last week 31-25, snapping a two-game losing skid. Buffalo lost to Toy last Saturday, which snapped a two-game winning streak for the Bulls. UConn will play without Mel Brown, while Javonte Vereen is questionable. Buffalo will play without Ryan Daly, while three others are questionable. Make sure to read this in-depth UConn Huskies vs Buffalo Bulls prediction. Buckle up! Dive into our top NCAAF picks for the UConn Huskies at Buffalo Bulls prediction and dominate your wagers.
UConn is strong on offense, but needs to improve its defense
The UConn Huskies average 493.8 yards of total offense per game, which is 16th in the nation, but the defense for the Huskies allows an average of 408.5 yards per game, which is 111th, out of 136. Connecticut scores an average of 39.3 points per game, which is 32nd, but allows an average of 27.3 points per game, which is 94th.
Connecticut's passing game is led by quarterback Joe Fagnano, who has 1,046 yards passing with six touchdowns. The Huskies are running the ball well, led by Cam Edwards with 500 yards, an average of 6.8 yards per carry, and five touchdowns. Skyler Bell has caught 36 passes for 445 yards, averaging 12.4 yards per reception with three touchdowns. Kicker Chris Freeman is 19-for-19 in extra points and 6-for-7 in field goals. Linebacker Bryun Parham is the heart of the defense, leading the Huskies with 35 tackles and 5.5 sacks. UConn’s defense has made 13.0 sacks and intercepted two passes.
Buffalo needs more from its offense, while its defense is above average
The Buffalo Bulls average 345.8 yards of total offense per game, which is 101st, while allowing an average of 337.5 yards per game, which is 58th. Buffalo is scoring an average of 25.8 points per game and allowing an average of 19.5 points per game, which are 87th and 47th, respectively.
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Buffalo quarterback Ta’Quan Roberson has 662 yards passing with five touchdowns and two interceptions. Roberson has been sacked three times. Roberson is listed as doubtful with a lower leg injury after being injured in their previous game. Al-Jay Henderson leads Buffalo in rushing with 274 yards and four touchdowns, averaging 3.8 yards per carry. Victor Snow has caught 16 passes for 206 yards with an average of 12.9 yards per reception and three touchdowns. Kicker Jack Howes has made each of his 13 extra points and four out of five field goal attempts. Linebacker Red Murdock leads Buffalo in tackles with 44, while defensive end Kobe Stewart is the leader in quarterback sacks with 2.5. Buffalo has made 16 sacks and intercepted two passes
UConn Huskies vs. Buffalo Bulls Pick
Spread Pick for UConn vs. Buffalo
- UConn Huskies -4.5 (5 units)
The UConn Huskies will be too much on offense for the Buffalo Bulls to contain. Connecticut's offense is strong both on the ground and through the air, led by running back Cam Edwards with 500 yards and an average of 6.8 yards per carry, while quarterback Joe Fagnano has 1,046 yards passing with six touchdowns and has not yet been intercepted. Connecticut is not as strong on defense, but Buffalo struggles on offense, averaging just 345.8 yards of total offense per game compared to Connecticut's 493.8 yards per game average for total offense. Buffalo has failed to cover the spread in each of the last two games, with one at home and one on the road. Connecticut has a strong kicking game, converting each of its 19 extra points and six of seven field goal attempts. The Huskies will bend on defense but not break, while scoring more than enough against a Buffalo defense that has problems stopping opponents.
Over/Under Pick for UConn vs. Buffalo
- Over 49 (4 units)
Connecticut has had the total finish over in three of its first four games this season. As mentioned previously, the Huskies are scoring an average of 39.3 points per game, which is 32nd, and allow an average of 27.3 points per game, which is 94th. Buffalo has had the total finish over and two of its last three games. Last season, the total finished over when these two met, as 50 points were scored on a closing line of 44.5 points.
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