UConn vs. Syracuse Pick and Prediction, Saturday, September 6, 2025
UConn (1-0, 0-0 Independent) will be trying to pick up their first road win of the season when they visit JMA Wireless Dome on Saturday afternoon to face Syracuse (0-1, 0-0 ACC) at 12 PM. ET. Read on to find out which team picks up the win in this Huskies vs. Orange prediction and get more College Football Betting Picks!
The Huskies are coming off a 59-13 win over Central Connecticut as 28.5-point favorites. The Orange are coming off a 45-26 loss to Tennessee as 13.5-point underdogs.
Syracuse and UConn split their last 10 meetings. The Orange won last season’s meeting 31-24.
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UConn Going For Second Consecutive Win
The Huskies got their season off to a good start with a win over Central Connecticut. They will be facing tougher competition this week and will try to pick up their first road win of the season when they play on Saturday.
UConn scored 59 points in their first game. They threw for 388 yards and rushed for 293 yards in the win.
Joe Fagnano completed 72 percent of his passes for 260 yards and three touchdowns. Cam Edwards led the team with six carries for 115 yards and one touchdown, while Skylar Bell led the team with four catches for 135 yards and two touchdowns.
UConn gave up 13 points in the first game. They gave up 129 passing yards and 128 rushing yards.
Syracuse Looking For First Win
The Orange couldn’t overcome a 17-point deficit in the first quarter of their first game and ended up getting blown out by Tennessee. They will be facing the Huskies in their home opener, and will need to avoid falling behind early again if they want to pick up their first win of the season.
Syracuse scored 26 points in their first game. They threw for 274 yards and rushed for 103 yards in the loss.
Steve Angeli completed 58 percent of his passes for 274 yards, one touchdown, and one interception. Yasin Willis had 23 carries for 91 yards and three touchdowns, while Johntay Cook had six catches for 58 yards and one touchdown.
Syracuse gave up 45 points in their first game. They gave up 247 passing yards and 248 rushing yards.
UConn vs. Syracuse Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Earle Sports Bets | +2,298.00 |
| 2 |  Ross Benjamin | +1,840.00 |
| 3 |  Rob Vincilleti | +1,757.00 |
| 4 |  David Hess | +1,745.00 |
| 5 |  Dan Kaiser | +987.00 |
Spread Pick for UConn vs. Syracuse
- Syracuse Orange -6.5
Even though the Orange lost their first game, they looked good offensively against what is considered to be one of the best defensive units in the country. They were able to throw the ball effectively, but didn’t do much damage on the ground. Even though the Huskies looked good defensively in their first game, they were facing an overmatched opponent, and will have a hard time slowing down the Orange.
UConn looked good offensively in their first game, but they won't be as successful in this game because they won’t be able to move the ball through the air effectively, which will force them to run the ball more than they would like. This will allow the Orange to stack the box and force the Huskies to make costly mistakes. Go with Syracuse to cover the spread.
Over/Under Pick for UConn vs. Syracuse
- Over 58.5
The Huskies played over the total in three of their last four games, while the Orange played over the total in their last four games. UConn scored 59 points in their last game. They rushed for over 200 yards, and they’re facing a team that struggled against the run in their first game and gave up 45 points. The Orange scored 26 points in their first game, and they moved the ball well through the air. They are facing a team that struggled against the run in their first game and gave up 13 points. Expect these teams to score enough points to push the score over the total. The Huskies and Orange played over the total in four of their last six meetings.
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