UTSA vs. Colorado State, Picks and Prediction, Saturday, September 20, 2025

By: Bosun Akinpelu Published 09/18/2025, 04:53 PM ET
Roadrunners vs. Rams prediction
Use Code WWWC

UTSA (1-2, 0-0 American) will be trying to pick up their first road win of the season when it visit Canvas Stadium on Saturday night to face Colorado State (1-1, 0-0 MW) at 9:30 PM. ET. Read on to find out which team picks up the win in this Roadrunners vs. Rams prediction. If you are struggling to pick winners, you've come to the right place. We have the strongest College Football Picks.

The Roadrunners are coming off a 48-20 win over Incarnate Word as 21-point favorites. The Rams are coming off a 21-17 win over Northern Colorado as 34.5-point favorites.

Colorado State is 2-0 in two games against UTSA. The last meeting between the two teams was in 2016.

UTSA Going For Second Consecutive Win

The Roadrunners snapped their two-game losing streak with a win over Incarnate Word in their last game, covering the spread for the seventh time in their last eight games. They will try to keep the momentum going and pick up their second straight win when they play on Saturday.

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UTSA averages 36 points per game. They are throwing for 210.7 yards and rushing for 215.7 yards per game.

Owen McCown has completed 65 percent of his passes for 583 yards and six touchdowns. He also has 11 carries for 57 yards. Robert Henry Jr. has 47 carries for 480 yards and six touchdowns, while Devin McCuin has 18 catches for 167 yards and two touchdowns.

UTSA is giving up 35 points per game. They are giving up 138 rushing yards and 288.5 passing yards per game.

Colorado State Going For Second Win In Three Games

The Rams bounced back from their season-opening loss to Washington with a win over Northern Colorado in their last game, giving them their first win of the season. They will try to keep the momentum going and pick up their second win in their last three games when they play on Saturday.

Colorado State is averaging 21 points per game through two games. They are throwing for 160.5 yards and rushing for 157.5 yards per game.

Brayden Fowler-Nicolosi has completed 53 percent of his passes for 312 yards, one touchdown, and two interceptions. Jalen Dupree has 28 carries for 150 yards and one touchdown, while Jaxxon Warren has seven catches for 95 yards and one touchdown.

Colorado State is giving up 27.5 points per game. They are giving up 283 rushing yards and 226 passing yards per game.

UTSA vs. Colorado State Pick

Point Spread Pick for UTSA vs. Colorado State

  • UTSA Roadrunners -5 (4 Units)

Neither team has played particularly well so far, but the Roadrunners have the edge here because they have one of the best ground games in the country, and they also throw the ball effectively. The Rams have been unable to stop the pass. They don’t get a lot of pressure on opposing quarterbacks, and opponents have also been able to run the ball against them, so expect the Roadrunners to have their way offensively in this game.

Colorado State won’t be as successful offensively because they don’t run the ball well and relies heavily on its passing game, which will allow the Roadrunners to keep pressure on McCown and prevent him from getting comfortable in the pocket. Take UTSA to cover the spread.

Over/Under Pick for UTSA vs. Colorado State

  • Over 59.5 (4 Units)

The Roadrunners played over the total in their last four games, while the Rams played over the total in four of their last five games. UTSA averages 36 points per game. They throw the ball 54 percent of the time, and they have the 68th-best passing attack in the country. They’re facing a team that is giving up more than 225 passing yards per game, and gave up 38 points in their first game against a good offense. The Rams average 21 points per game. They throw the ball 56 percent of the tim,e and they have the 96th-best passing attack in the country. They are facing a team that is 119th against the pass and is giving up 35 points per game. Expect these teams to score enough points to push the score over the total.

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