UTSA vs. South Florida, Preview, Odds, Picks and Prediction, Thursday, November 6, 2025
Use Code WWWC UTSA (4-4, 2-2 American) will be trying to snap their two-game road losing streak when they visit Raymond James Stadium on Thursday night to face South Florida (6-2, 3-1 American) at 7:30 PM. ET. Read on to find out which team picks up the win in this Roadrunners vs. Bulls prediction. When it comes to NCAAF selections, our College Football Picks are stellar.
The Roadrunners are coming off a 48-26 win over Tulane as six-point underdogs. The Bulls are coming off a 34-31 loss to Memphis as 3.5-point favorites.
UTSA won the lone meeting between the two teams in 2023, 49-21.
UTSA Going For Second Consecutive Win
The Roadrunners bounced back from their loss to North Texas with a win over Tulane in their last game as a 5.5-point home dog. After Tulane scored an opening touchdown, UTSA scored 31 unanswered points to take command 31-6 and never really looked back. QB Owen McCown threw for 370 yards with four TDs, as the Roadrunners amassed 523 yards of offense.
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UTSA averages 34 points per game, which is 35th in the nation. They throw for 223.9 yards and rush for 178.3 yards per game.
Owen McCown has completed 68 percent of his passes for 1,680 yards, 17 touchdowns, and four interceptions. Robert Henry Jr. leads the team with 120 carries for 955 yards and nine touchdowns, while Devin McCuin leads the team with 43 catches for 460 yards and six touchdowns.
UTSA is giving up 30.3 points per game, which is 109th in the nation. They’re giving up 243.4 passing yards and 166 rushing yards per game.
Injuries: WR- Willie McCoy (Undisclosed) is questionable for this game.
South Florida Trying To Bounce Back From Loss
The Bulls had their four-game winning streak snapped by the Memphis Tigers in their last game, dropping them to third in the AAC standings. The Bulls were up 31-17 going into the fourth quarter and allowed 17 points to fall by three. Byrum ran for 121 yards and two TDs and threw for 269 yards with a TD and a pick to lead USF. The Bulls ran for 295 yards, but allowed 321 passing yards.
USF averages 40.4 points per game, which is sixth in the nation. They throw for 261.5 yards and rush for 225.5 yards per game.
Byrum Brown has completed 63 percent of his passes for 1,964 yards, 17 touchdowns, and six interceptions. He also leads the team with 596 rushing yards and eight touchdowns. Sam Franklin has 50 carries for 356 yards and four touchdowns, while Chas Nimrod has 23 catches for 466 yards and three touchdowns.
South Florida is giving up 24.4 points per game, which is 70th in the nation. They’re giving up 276.3 passing yards and 121.3 rushing yards per game.
Injuries: RB- Tray Kinkle (Undisclosed), WR- Jaden Alexis (Undisclosed), TE-Weston Wolff (Undisclosed), WR-Kory Pettigrew (Undisclosed), and Chas Nimrod (Undisclosed) are questionable for this game.
UTSA vs. USF Picks
Point Spread Pick for UTSA vs. USF
- USF Bulls -14 (4 Units)
The Bulls have won four of their last five games, while the Roadrunners have won four of their last six games. USF has the edge here because they have a balanced offense, with one of the best passing and running games in the country. The Roadrunners have one of the worst pass defenses in the country, and their ground game isn’t much better, so expect them to have a hard time slowing down the Bulls.
UTSA will have a hard time keeping up with the Bulls because they run the ball well, but their passing game isn’t as good. The Bulls have a good ground defense and will limit the damage the Roadrunners do on the ground, which will allow them to keep pressure on McCown and force him to make costly mistakes. Take South Florida to cover the spread.
Over/Under Pick for UTSA vs. USF
- Over 68.5
The Roadrunners played over the total in their last three games, while the Bulls played over the total in five of their last six games. UTSA averages 34 points per game. They throw the ball 51 percent of the time with the 78th-ranked passing attack in the country, and they’re facing a team that is 126th against the pass and is giving up 25.7 points per game at home. The Bulls average 40.4 points per game. They run the ball 54 percent of the time with the 12th-ranked ground game in the country, and they’re facing a team that is 84th against the run and is giving up 35 points per game on the road. Expect these teams to score enough points to push the score over the total.
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